Exercise-induced Citrate Enhances Associative Memory Formation by Modulating Histone Acetylation in a Sex-dependent manner
Exercise stimulates the release of metabolites from the liver and muscles known as "exercise factors" into the circulation. The benefits of exercise on cognition are mediated by an increase in brain-derived neurotrophic factor (BDNF) levels in the hippocampus. Identifying these exercise-re...
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| Format: | masterThesis |
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2023
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| Online Access: | http://hdl.handle.net/10725/15278 https://doi.org/10.26756/th.2023.635 http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php |
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| _version_ | 1864513470419959808 |
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| author | El Masri, Diala |
| author_facet | El Masri, Diala |
| author_role | author |
| dc.creator.none.fl_str_mv | El Masri, Diala |
| dc.date.none.fl_str_mv | 2023 2023-07-31 2024-01-22T11:27:29Z 2024-01-22T11:27:29Z |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10725/15278 https://doi.org/10.26756/th.2023.635 http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Lebanese American University |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Memory consolidation Cognition--Effect of exercise on Histones Lebanese American University--Dissertations Dissertations, Academic |
| dc.title.none.fl_str_mv | Exercise-induced Citrate Enhances Associative Memory Formation by Modulating Histone Acetylation in a Sex-dependent manner |
| dc.type.none.fl_str_mv | Thesis info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/masterThesis |
| description | Exercise stimulates the release of metabolites from the liver and muscles known as "exercise factors" into the circulation. The benefits of exercise on cognition are mediated by an increase in brain-derived neurotrophic factor (BDNF) levels in the hippocampus. Identifying these exercise-related factors could provide a detailed insight on the processes by which exercise exerts its positive effects on cognition. Previous work has shown that the levels of citrate, a Kreb’s cycle intermediate, are increased in the circulation upon exercise. In this study, we tested whether exogenous administration of citrate enhances learning and memory formation in a sex-dependent manner and elucidated the underlying molecular mechanisms. Our results show that citrate enhances associative memory formation in male mice, but not female mice. In males. citrate is released by the muscles during exercise, crosses the blood-brain barrier and induces TrkB overexpression in the hippocampus. In fact, we found that citrate-dependent enhancement of learning and memory is linked to an increase in hippocampal histone acetylation, specifically acetylation of histone H4. This increase is accompanied with a decrease in hippocampal HDAC2, leading to the expression of immediate early genes involved in synaptic plasticity. Overall, our findings suggest that citrate may be an endogenous molecule that mediates exercise-induced memory formation in male mice. |
| eu_rights_str_mv | openAccess |
| format | masterThesis |
| id | LAURepo_3fceb9347844ffeab49abbdbc629d233 |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/15278 |
| publishDate | 2023 |
| publisher.none.fl_str_mv | Lebanese American University |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Exercise-induced Citrate Enhances Associative Memory Formation by Modulating Histone Acetylation in a Sex-dependent mannerEl Masri, DialaMemory consolidationCognition--Effect of exercise onHistonesLebanese American University--DissertationsDissertations, AcademicExercise stimulates the release of metabolites from the liver and muscles known as "exercise factors" into the circulation. The benefits of exercise on cognition are mediated by an increase in brain-derived neurotrophic factor (BDNF) levels in the hippocampus. Identifying these exercise-related factors could provide a detailed insight on the processes by which exercise exerts its positive effects on cognition. Previous work has shown that the levels of citrate, a Kreb’s cycle intermediate, are increased in the circulation upon exercise. In this study, we tested whether exogenous administration of citrate enhances learning and memory formation in a sex-dependent manner and elucidated the underlying molecular mechanisms. Our results show that citrate enhances associative memory formation in male mice, but not female mice. In males. citrate is released by the muscles during exercise, crosses the blood-brain barrier and induces TrkB overexpression in the hippocampus. In fact, we found that citrate-dependent enhancement of learning and memory is linked to an increase in hippocampal histone acetylation, specifically acetylation of histone H4. This increase is accompanied with a decrease in hippocampal HDAC2, leading to the expression of immediate early genes involved in synaptic plasticity. Overall, our findings suggest that citrate may be an endogenous molecule that mediates exercise-induced memory formation in male mice.1 online resource (xi, 55 leaves): ill. (some col.)Includes bibliographical references (leaves 43-55)Lebanese American University2024-01-22T11:27:29Z2024-01-22T11:27:29Z20232023-07-31Thesisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesishttp://hdl.handle.net/10725/15278https://doi.org/10.26756/th.2023.635http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.phpeninfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/152782024-01-22T11:28:31Z |
| spellingShingle | Exercise-induced Citrate Enhances Associative Memory Formation by Modulating Histone Acetylation in a Sex-dependent manner El Masri, Diala Memory consolidation Cognition--Effect of exercise on Histones Lebanese American University--Dissertations Dissertations, Academic |
| status_str | publishedVersion |
| title | Exercise-induced Citrate Enhances Associative Memory Formation by Modulating Histone Acetylation in a Sex-dependent manner |
| title_full | Exercise-induced Citrate Enhances Associative Memory Formation by Modulating Histone Acetylation in a Sex-dependent manner |
| title_fullStr | Exercise-induced Citrate Enhances Associative Memory Formation by Modulating Histone Acetylation in a Sex-dependent manner |
| title_full_unstemmed | Exercise-induced Citrate Enhances Associative Memory Formation by Modulating Histone Acetylation in a Sex-dependent manner |
| title_short | Exercise-induced Citrate Enhances Associative Memory Formation by Modulating Histone Acetylation in a Sex-dependent manner |
| title_sort | Exercise-induced Citrate Enhances Associative Memory Formation by Modulating Histone Acetylation in a Sex-dependent manner |
| topic | Memory consolidation Cognition--Effect of exercise on Histones Lebanese American University--Dissertations Dissertations, Academic |
| url | http://hdl.handle.net/10725/15278 https://doi.org/10.26756/th.2023.635 http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php |