Diphtheria toxin-murine granulocyte-macrophage colony-stimulating factor–induced hepatotoxicity is mediated by Kupffer cells
DT388GMCSF, a fusion toxin composed of the NH2-terminal region of diphtheria toxin (DT) fused to human granulocyte-macrophage colony-stimulating factor (GMCSF) has shown efficacy in the treatment of acute myeloid leukemia. However, the primary dose-limiting side effect is liver toxicity. We have rep...
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| Other Authors: | , , , , , , |
| Format: | article |
| Published: |
2004
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| Online Access: | http://hdl.handle.net/10725/2736 http://mct.aacrjournals.org/content/3/12/1681.short |
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