Cancer stem cells in neuroblastoma
Neuroblastoma (NB) is the most common extracranial solid tumor often diagnosed in childhood. Despite intense efforts to develop a successful treatment, current available therapies are still challenged by high rates of resistance, recurrence and progression, most notably in advanced cases and highly...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | , , , , |
| Format: | article |
| Published: |
2019
|
| Online Access: | http://hdl.handle.net/10725/11502 https://doi.org/10.3389/fnmol.2019.00131 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.frontiersin.org/articles/10.3389/fnmol.2019.00131/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1864513488813031424 |
|---|---|
| author | Bahmad, Hisham F. |
| author2 | Chamaa, Farah Assi, Sahar Chalhoub, Reda M. Abou-Antoun, Tamara Abou-Kheir, Wassim |
| author2_role | author author author author author |
| author_facet | Bahmad, Hisham F. Chamaa, Farah Assi, Sahar Chalhoub, Reda M. Abou-Antoun, Tamara Abou-Kheir, Wassim |
| author_role | author |
| dc.creator.none.fl_str_mv | Bahmad, Hisham F. Chamaa, Farah Assi, Sahar Chalhoub, Reda M. Abou-Antoun, Tamara Abou-Kheir, Wassim |
| dc.date.none.fl_str_mv | 2019-11-07T12:14:13Z 2019-11-07T12:14:13Z 2019 2019-11-07 |
| dc.identifier.none.fl_str_mv | 1662-5099 http://hdl.handle.net/10725/11502 https://doi.org/10.3389/fnmol.2019.00131 Bahmad, H. F., Chamaa, F. O., Assi, S., Chalhoub, R. M., Abou-Antoun, T., & Abou-Kheir, W. (2019). Cancer Stem Cells in Neuroblastoma: Expanding the Therapeutic Frontier. Frontiers in molecular neuroscience, 12, 131. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.frontiersin.org/articles/10.3389/fnmol.2019.00131/full |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Frontiers in Molecular Neuroscience |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Cancer stem cells in neuroblastoma expanding the therapeutic frontier |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Neuroblastoma (NB) is the most common extracranial solid tumor often diagnosed in childhood. Despite intense efforts to develop a successful treatment, current available therapies are still challenged by high rates of resistance, recurrence and progression, most notably in advanced cases and highly malignant tumors. Emerging evidence proposes that this might be due to a subpopulation of cancer stem cells (CSCs) or tumor-initiating cells (TICs) found in the bulk of the tumor. Therefore, the development of more targeted therapy is highly dependent on the identification of the molecular signatures and genetic aberrations characteristic to this subpopulation of cells. This review aims at providing an overview of the key molecular players involved in NB CSCs and focuses on the experimental evidence from NB cell lines, patient-derived xenografts and primary tumors. It also provides some novel approaches of targeting multiple drivers governing the stemness of CSCs to achieve better anti-tumor effects than the currently used therapeutic agents. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_4898d04d8f455c90dd74dfabeb040e9b |
| identifier_str_mv | 1662-5099 Bahmad, H. F., Chamaa, F. O., Assi, S., Chalhoub, R. M., Abou-Antoun, T., & Abou-Kheir, W. (2019). Cancer Stem Cells in Neuroblastoma: Expanding the Therapeutic Frontier. Frontiers in molecular neuroscience, 12, 131. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/11502 |
| publishDate | 2019 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Cancer stem cells in neuroblastomaexpanding the therapeutic frontierBahmad, Hisham F.Chamaa, FarahAssi, SaharChalhoub, Reda M.Abou-Antoun, TamaraAbou-Kheir, WassimNeuroblastoma (NB) is the most common extracranial solid tumor often diagnosed in childhood. Despite intense efforts to develop a successful treatment, current available therapies are still challenged by high rates of resistance, recurrence and progression, most notably in advanced cases and highly malignant tumors. Emerging evidence proposes that this might be due to a subpopulation of cancer stem cells (CSCs) or tumor-initiating cells (TICs) found in the bulk of the tumor. Therefore, the development of more targeted therapy is highly dependent on the identification of the molecular signatures and genetic aberrations characteristic to this subpopulation of cells. This review aims at providing an overview of the key molecular players involved in NB CSCs and focuses on the experimental evidence from NB cell lines, patient-derived xenografts and primary tumors. It also provides some novel approaches of targeting multiple drivers governing the stemness of CSCs to achieve better anti-tumor effects than the currently used therapeutic agents.PublishedN/A2019-11-07T12:14:13Z2019-11-07T12:14:13Z20192019-11-07Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1662-5099http://hdl.handle.net/10725/11502https://doi.org/10.3389/fnmol.2019.00131Bahmad, H. F., Chamaa, F. O., Assi, S., Chalhoub, R. M., Abou-Antoun, T., & Abou-Kheir, W. (2019). Cancer Stem Cells in Neuroblastoma: Expanding the Therapeutic Frontier. Frontiers in molecular neuroscience, 12, 131.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://www.frontiersin.org/articles/10.3389/fnmol.2019.00131/fullenFrontiers in Molecular Neuroscienceinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/115022021-03-19T10:47:38Z |
| spellingShingle | Cancer stem cells in neuroblastoma Bahmad, Hisham F. |
| status_str | publishedVersion |
| title | Cancer stem cells in neuroblastoma |
| title_full | Cancer stem cells in neuroblastoma |
| title_fullStr | Cancer stem cells in neuroblastoma |
| title_full_unstemmed | Cancer stem cells in neuroblastoma |
| title_short | Cancer stem cells in neuroblastoma |
| title_sort | Cancer stem cells in neuroblastoma |
| url | http://hdl.handle.net/10725/11502 https://doi.org/10.3389/fnmol.2019.00131 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.frontiersin.org/articles/10.3389/fnmol.2019.00131/full |