Can plasma vitamin C predict survival in stage IV colorectal cancer patients? Results of a prospective cohort study
Background and Aims: In light of the inconclusive evidence on the association between vitamin C status and colorectal cancer (CRC) outcome, this study assessed the prognostic value of vitamin C in participants with metastatic CRC (mCRC). Methods: Adults with mCRC and cancer-free controls were recrui...
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| مؤلفون آخرون: | , , , , , , , , |
| التنسيق: | article |
| منشور في: |
2023
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/16563 https://doi.org/10.3389/fnut.2023.1110405 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2023.1110405/full |
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| _version_ | 1864513472918716416 |
|---|---|
| author | Temraz, Sally |
| author2 | Jabbour, Jana Nassar, Farah El Helou, Remie Hadla, Ruba Mezher, Maria El Lakkiss, Ahmed Charafeddine, Maya Nasr, Rihab Shamseddine, Ali |
| author2_role | author author author author author author author author author |
| author_facet | Temraz, Sally Jabbour, Jana Nassar, Farah El Helou, Remie Hadla, Ruba Mezher, Maria El Lakkiss, Ahmed Charafeddine, Maya Nasr, Rihab Shamseddine, Ali |
| author_role | author |
| dc.creator.none.fl_str_mv | Temraz, Sally Jabbour, Jana Nassar, Farah El Helou, Remie Hadla, Ruba Mezher, Maria El Lakkiss, Ahmed Charafeddine, Maya Nasr, Rihab Shamseddine, Ali |
| dc.date.none.fl_str_mv | 2023 2023-03-06 2025-02-13T09:03:07Z 2025-02-13T09:03:07Z |
| dc.identifier.none.fl_str_mv | 2296-861X http://hdl.handle.net/10725/16563 https://doi.org/10.3389/fnut.2023.1110405 Temraz, S., Jabbour, J., Nassar, F., El Helou, R., Hadla, R., Mezher, M., ... & Shamseddine, A. (2023). Can plasma vitamin C predict survival in stage IV colorectal cancer patients? Results of a prospective cohort study. Frontiers in Nutrition, 10, 1-7. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2023.1110405/full |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Frontiers in Nutrition |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Can plasma vitamin C predict survival in stage IV colorectal cancer patients? Results of a prospective cohort study |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Background and Aims: In light of the inconclusive evidence on the association between vitamin C status and colorectal cancer (CRC) outcome, this study assessed the prognostic value of vitamin C in participants with metastatic CRC (mCRC). Methods: Adults with mCRC and cancer-free controls were recruited in this prospective cohort study to allow for comparison of vitamin C levels with healthy individuals from the same population. Sociodemographic, lifestyle, medical variables, BRAF and KRAS mutations, as well as Vitamin C plasma level and food intake were evaluated. Predictors of diminished vitamin C level were assessed via multivariate logistic regression. Mortality and progression free survival (PFS) among mCRC participants were analyzed based on plasma vitamin C level. Results: The cancer group (n = 46) was older (mean age: 60 ± 14 vs. 42 ± 9.6, p = 0.047) and included more males (29% vs. 19%, p < 0.001) than the cancer-free group (n = 45). There was a non-significant difference in the vitamin C intake between the two groups; however, the mean plasma vitamin C level was lower in the cancer group (3.5 ± 3.7 vs. 9.2 ± 5.6 mg/l, p < 0.001). After adjusting for age and gender, the cancer group was more likely to be deficient compared to the cancer-free group [Adjusted Odds Ratio (95%CI): 5.4 (2.1–14)]. There was a non-significant trend for higher mortality in the vitamin C deficient cancer group (31% vs. 12%, p = 0.139). PFS did not differ based on vitamin C deficiency and patients with BRAF and KRAS mutations did not have significant differences in vitamin C levels. Conclusion: mCRC patients have lower plasma vitamin C levels than healthy controls. The trend toward higher mortality in the vitamin C deficient cancer group was not statistically significant. Whether this phenomenon affects survival and response to treatment warrants further exploration in phase III clinical trials. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_48d8a22896b1f1ca084f64c431c0bacb |
| identifier_str_mv | 2296-861X Temraz, S., Jabbour, J., Nassar, F., El Helou, R., Hadla, R., Mezher, M., ... & Shamseddine, A. (2023). Can plasma vitamin C predict survival in stage IV colorectal cancer patients? Results of a prospective cohort study. Frontiers in Nutrition, 10, 1-7. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/16563 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Can plasma vitamin C predict survival in stage IV colorectal cancer patients? Results of a prospective cohort studyTemraz, SallyJabbour, JanaNassar, FarahEl Helou, RemieHadla, RubaMezher, MariaEl Lakkiss, AhmedCharafeddine, MayaNasr, RihabShamseddine, AliBackground and Aims: In light of the inconclusive evidence on the association between vitamin C status and colorectal cancer (CRC) outcome, this study assessed the prognostic value of vitamin C in participants with metastatic CRC (mCRC). Methods: Adults with mCRC and cancer-free controls were recruited in this prospective cohort study to allow for comparison of vitamin C levels with healthy individuals from the same population. Sociodemographic, lifestyle, medical variables, BRAF and KRAS mutations, as well as Vitamin C plasma level and food intake were evaluated. Predictors of diminished vitamin C level were assessed via multivariate logistic regression. Mortality and progression free survival (PFS) among mCRC participants were analyzed based on plasma vitamin C level. Results: The cancer group (n = 46) was older (mean age: 60 ± 14 vs. 42 ± 9.6, p = 0.047) and included more males (29% vs. 19%, p < 0.001) than the cancer-free group (n = 45). There was a non-significant difference in the vitamin C intake between the two groups; however, the mean plasma vitamin C level was lower in the cancer group (3.5 ± 3.7 vs. 9.2 ± 5.6 mg/l, p < 0.001). After adjusting for age and gender, the cancer group was more likely to be deficient compared to the cancer-free group [Adjusted Odds Ratio (95%CI): 5.4 (2.1–14)]. There was a non-significant trend for higher mortality in the vitamin C deficient cancer group (31% vs. 12%, p = 0.139). PFS did not differ based on vitamin C deficiency and patients with BRAF and KRAS mutations did not have significant differences in vitamin C levels. Conclusion: mCRC patients have lower plasma vitamin C levels than healthy controls. The trend toward higher mortality in the vitamin C deficient cancer group was not statistically significant. Whether this phenomenon affects survival and response to treatment warrants further exploration in phase III clinical trials.Published2025-02-13T09:03:07Z2025-02-13T09:03:07Z20232023-03-06Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2296-861Xhttp://hdl.handle.net/10725/16563https://doi.org/10.3389/fnut.2023.1110405Temraz, S., Jabbour, J., Nassar, F., El Helou, R., Hadla, R., Mezher, M., ... & Shamseddine, A. (2023). Can plasma vitamin C predict survival in stage IV colorectal cancer patients? Results of a prospective cohort study. Frontiers in Nutrition, 10, 1-7.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2023.1110405/fullenFrontiers in Nutritioninfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/165632025-02-26T14:46:31Z |
| spellingShingle | Can plasma vitamin C predict survival in stage IV colorectal cancer patients? Results of a prospective cohort study Temraz, Sally |
| status_str | publishedVersion |
| title | Can plasma vitamin C predict survival in stage IV colorectal cancer patients? Results of a prospective cohort study |
| title_full | Can plasma vitamin C predict survival in stage IV colorectal cancer patients? Results of a prospective cohort study |
| title_fullStr | Can plasma vitamin C predict survival in stage IV colorectal cancer patients? Results of a prospective cohort study |
| title_full_unstemmed | Can plasma vitamin C predict survival in stage IV colorectal cancer patients? Results of a prospective cohort study |
| title_short | Can plasma vitamin C predict survival in stage IV colorectal cancer patients? Results of a prospective cohort study |
| title_sort | Can plasma vitamin C predict survival in stage IV colorectal cancer patients? Results of a prospective cohort study |
| url | http://hdl.handle.net/10725/16563 https://doi.org/10.3389/fnut.2023.1110405 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2023.1110405/full |