Cyclosporine lymphocyte maximum level
Objectives: To determine the relationship between clinical outcome, lymphocyte count (LC), and cyclosporine (CsA) lymphocyte maximum level (LTmL) in kidney transplant recipients. Materials and Methods: CsA LTmL was determined in patients with biopsy-proven graft dysfunction and in patients with norm...
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2005
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| Online Access: | http://hdl.handle.net/10725/10372 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.ectrx.org/forms/ectrxcontentshow.php?year=2005&volume=3&issue=1&supplement=0&makale_no=0&spage_number=293&content_type=FULL%20TEXT |
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| _version_ | 1864513486571175937 |
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| author | Kilani, Halal E. |
| author2 | Karam, Albert S. Masri, Marwan A. Stephan, Antoine G. Mourad, Nina El Ghoul, Bassam |
| author2_role | author author author author author |
| author_facet | Kilani, Halal E. Karam, Albert S. Masri, Marwan A. Stephan, Antoine G. Mourad, Nina El Ghoul, Bassam |
| author_role | author |
| dc.creator.none.fl_str_mv | Kilani, Halal E. Karam, Albert S. Masri, Marwan A. Stephan, Antoine G. Mourad, Nina El Ghoul, Bassam |
| dc.date.none.fl_str_mv | 2005 2019-04-09T06:13:09Z 2019-04-09T06:13:09Z 2019-04-09 |
| dc.identifier.none.fl_str_mv | 2146-8427 http://hdl.handle.net/10725/10372 Barbari, A. G., Masri, M. A., Stephan, A. G., Mourad, N., El-Ghoul, B., Kamel, G. S., ... & Karam, A. S. (2005). Cyclosporine lymphocyte maximum level: a new alternative for cyclosporine monitoring in kidney transplantation. Exp Clin Transplant, 3(1), 293-300. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.ectrx.org/forms/ectrxcontentshow.php?year=2005&volume=3&issue=1&supplement=0&makale_no=0&spage_number=293&content_type=FULL%20TEXT |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Experimental and clinical transplantation |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Cyclosporine lymphocyte maximum level a new alternative for cyclosporine monitoring in kidney transplantation |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Objectives: To determine the relationship between clinical outcome, lymphocyte count (LC), and cyclosporine (CsA) lymphocyte maximum level (LTmL) in kidney transplant recipients. Materials and Methods: CsA LTmL was determined in patients with biopsy-proven graft dysfunction and in patients with normal graft function. Clinical outcome was compared according to CsA LTmL, dosage, blood trough (C0) and maximum (Cmax) levels, hematocrit level, and LC. Results: Rejecting patients had significantly lower LTmL than did those with normal graft function (27 ± 11 pg/Lc vs 71 ± 79 pg/Lc; P < 0.01) and similar LTmL to those with nephrotoxicity (27 ± 8 pg/Lc). Patients with normal graft function exhibited significantly lower LC (0.001292 ± 696 x 109/L) and serum creatinine levels (88.4 ± 35 µmol/L) when compared with rejecting patients (0.001717 ± 364 x 109/L, 132.6 ± 8.8 µmol/L) and those with nephrotoxicity (0.001884 ± 582 x 109/L, 123.7 ± 8.8 µmol/L) (P < 0.03, P < 0.001). No significant difference was observed among the 3 groups with regard to CsA dosage, C0, Cmax, mycophenolate mofetil (MMF) dosage, and mycophenolic acid (MPA) plasma levels. CsA LTmL closely correlated in an exponential (R2 = 0.98) and linear (R2 = 0.35) fashion with LC and hematocrit level, respectively. Conversely, CsA Cmax failed to correlate with C0 and these 2 latter parameters. Weak correlations were observed between CsA Cmax and its corresponding LTmL. Conclusions: CsA LTmL appears to correlate better than CsA Cmax with rejection-free outcome and LC. An increase in hematocrit appears to have an adverse effect on CsA lymphocyte binding. CsA LTmL may offer a new alternative for CsA monitoring in kidney transplantation. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_49254a1e15fd4e8eac02af1ebb60ac56 |
| identifier_str_mv | 2146-8427 Barbari, A. G., Masri, M. A., Stephan, A. G., Mourad, N., El-Ghoul, B., Kamel, G. S., ... & Karam, A. S. (2005). Cyclosporine lymphocyte maximum level: a new alternative for cyclosporine monitoring in kidney transplantation. Exp Clin Transplant, 3(1), 293-300. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/10372 |
| publishDate | 2005 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Cyclosporine lymphocyte maximum levela new alternative for cyclosporine monitoring in kidney transplantationKilani, Halal E.Karam, Albert S.Masri, Marwan A.Stephan, Antoine G.Mourad, NinaEl Ghoul, BassamObjectives: To determine the relationship between clinical outcome, lymphocyte count (LC), and cyclosporine (CsA) lymphocyte maximum level (LTmL) in kidney transplant recipients. Materials and Methods: CsA LTmL was determined in patients with biopsy-proven graft dysfunction and in patients with normal graft function. Clinical outcome was compared according to CsA LTmL, dosage, blood trough (C0) and maximum (Cmax) levels, hematocrit level, and LC. Results: Rejecting patients had significantly lower LTmL than did those with normal graft function (27 ± 11 pg/Lc vs 71 ± 79 pg/Lc; P < 0.01) and similar LTmL to those with nephrotoxicity (27 ± 8 pg/Lc). Patients with normal graft function exhibited significantly lower LC (0.001292 ± 696 x 109/L) and serum creatinine levels (88.4 ± 35 µmol/L) when compared with rejecting patients (0.001717 ± 364 x 109/L, 132.6 ± 8.8 µmol/L) and those with nephrotoxicity (0.001884 ± 582 x 109/L, 123.7 ± 8.8 µmol/L) (P < 0.03, P < 0.001). No significant difference was observed among the 3 groups with regard to CsA dosage, C0, Cmax, mycophenolate mofetil (MMF) dosage, and mycophenolic acid (MPA) plasma levels. CsA LTmL closely correlated in an exponential (R2 = 0.98) and linear (R2 = 0.35) fashion with LC and hematocrit level, respectively. Conversely, CsA Cmax failed to correlate with C0 and these 2 latter parameters. Weak correlations were observed between CsA Cmax and its corresponding LTmL. Conclusions: CsA LTmL appears to correlate better than CsA Cmax with rejection-free outcome and LC. An increase in hematocrit appears to have an adverse effect on CsA lymphocyte binding. CsA LTmL may offer a new alternative for CsA monitoring in kidney transplantation.PublishedN/A2019-04-09T06:13:09Z2019-04-09T06:13:09Z20052019-04-09Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2146-8427http://hdl.handle.net/10725/10372Barbari, A. G., Masri, M. A., Stephan, A. G., Mourad, N., El-Ghoul, B., Kamel, G. S., ... & Karam, A. S. (2005). Cyclosporine lymphocyte maximum level: a new alternative for cyclosporine monitoring in kidney transplantation. Exp Clin Transplant, 3(1), 293-300.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttp://www.ectrx.org/forms/ectrxcontentshow.php?year=2005&volume=3&issue=1&supplement=0&makale_no=0&spage_number=293&content_type=FULL%20TEXTenExperimental and clinical transplantationinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/103722021-03-19T10:45:18Z |
| spellingShingle | Cyclosporine lymphocyte maximum level Kilani, Halal E. |
| status_str | publishedVersion |
| title | Cyclosporine lymphocyte maximum level |
| title_full | Cyclosporine lymphocyte maximum level |
| title_fullStr | Cyclosporine lymphocyte maximum level |
| title_full_unstemmed | Cyclosporine lymphocyte maximum level |
| title_short | Cyclosporine lymphocyte maximum level |
| title_sort | Cyclosporine lymphocyte maximum level |
| url | http://hdl.handle.net/10725/10372 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.ectrx.org/forms/ectrxcontentshow.php?year=2005&volume=3&issue=1&supplement=0&makale_no=0&spage_number=293&content_type=FULL%20TEXT |