The effect of vancomycin doses greater than 2 grams on serum creatinine and vancomycin trough levels
Objective: To assess the effect of vancomycin doses greater than 2 grams on renal function and vancomycin trough levels Methods: This is a retrospective, pharmacokinetic study performed in a tertiary care level II trauma center. 3579 electronic charts of patients who received vancomcyin at the medic...
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2014
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| Online Access: | http://hdl.handle.net/10725/4461 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://innovareacademics.in/journals/index.php/ijpps/article/view/2791 |
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| author | Mansour, Hanine |
| author2 | Bush, Jeffrey A Brito, Micheal Novotny, Paul Courtney, Cale Mustonen, Jordan Towey, Kim |
| author2_role | author author author author author author |
| author_facet | Mansour, Hanine Bush, Jeffrey A Brito, Micheal Novotny, Paul Courtney, Cale Mustonen, Jordan Towey, Kim |
| author_role | author |
| dc.creator.none.fl_str_mv | Mansour, Hanine Bush, Jeffrey A Brito, Micheal Novotny, Paul Courtney, Cale Mustonen, Jordan Towey, Kim |
| dc.date.none.fl_str_mv | 2014 2016-09-30T05:54:56Z 2016-09-30T05:54:56Z 2016-09-30 |
| dc.identifier.none.fl_str_mv | 0975–1491 http://hdl.handle.net/10725/4461 Mansour, H., Bush, J. A., Brito, M., Novotny, P., Courtney, C., Mustonen, J., & Towey, K. (2014). The effect of vancomycin doses greater than 2 grams on serum creatinine and vancomycin trough levels. International Journal of Pharmacy and Pharmaceutical Sciences, 6(8), 621-625. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://innovareacademics.in/journals/index.php/ijpps/article/view/2791 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | International Journal of Pharmacy and Pharmaceutical Sciences |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | The effect of vancomycin doses greater than 2 grams on serum creatinine and vancomycin trough levels |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Objective: To assess the effect of vancomycin doses greater than 2 grams on renal function and vancomycin trough levels Methods: This is a retrospective, pharmacokinetic study performed in a tertiary care level II trauma center. 3579 electronic charts of patients who received vancomcyin at the medical facility between January 2010 and December 2011 were reviewed. Only 30 patients met the inclusion criteria of the study. Included patients were those who were at least 18 years of age who received doses greater than 2 grams of vancomycin for at least 48 hours. Patients in the intensive care units, pregnant or on hemodialysis and were not included in the study. The mean weight for the participants was 154.67 kg. Results: Patients were dosed based on the institution’s vancomycin dosing protocol such as 15-20 mg/kg per dose where the frequency was determined based on the estimated creatinine clearance using cockroft gault equation. A loading dose of 25-30 mg/kg was administered in few cases. Two out of thirty subjects had shown an increase of serum creatinine of ≥ 0.3mg/dL when receiving maintenance doses greater than 2 grams of vancomycin. A Z approximation test was used where a standard error of 0.043 with an α error equal to 0.05 and a 95% confidence interval of (-0.024-0.144) were found. The use of doses greater than 2 grams of IV vancomycin did not show a statistically significance increase in serum creatinine. The two subjects who did have a significant increase in serum creatinine were receiving concomitant nephrotoxins. Conclusion: The use of doses greater than 2 grams of IV vancomycin did not show a statistically significant increase in serum creatinine. Patients whom serum creatinine increased were on other nephrotoxin agents that could have contributed to the acute kidney injury that was seen in these patients. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_497ca313b7816c338cdac5c0e26bcf52 |
| identifier_str_mv | 0975–1491 Mansour, H., Bush, J. A., Brito, M., Novotny, P., Courtney, C., Mustonen, J., & Towey, K. (2014). The effect of vancomycin doses greater than 2 grams on serum creatinine and vancomycin trough levels. International Journal of Pharmacy and Pharmaceutical Sciences, 6(8), 621-625. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/4461 |
| publishDate | 2014 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
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| spelling | The effect of vancomycin doses greater than 2 grams on serum creatinine and vancomycin trough levelsMansour, HanineBush, Jeffrey ABrito, MichealNovotny, PaulCourtney, CaleMustonen, JordanTowey, KimObjective: To assess the effect of vancomycin doses greater than 2 grams on renal function and vancomycin trough levels Methods: This is a retrospective, pharmacokinetic study performed in a tertiary care level II trauma center. 3579 electronic charts of patients who received vancomcyin at the medical facility between January 2010 and December 2011 were reviewed. Only 30 patients met the inclusion criteria of the study. Included patients were those who were at least 18 years of age who received doses greater than 2 grams of vancomycin for at least 48 hours. Patients in the intensive care units, pregnant or on hemodialysis and were not included in the study. The mean weight for the participants was 154.67 kg. Results: Patients were dosed based on the institution’s vancomycin dosing protocol such as 15-20 mg/kg per dose where the frequency was determined based on the estimated creatinine clearance using cockroft gault equation. A loading dose of 25-30 mg/kg was administered in few cases. Two out of thirty subjects had shown an increase of serum creatinine of ≥ 0.3mg/dL when receiving maintenance doses greater than 2 grams of vancomycin. A Z approximation test was used where a standard error of 0.043 with an α error equal to 0.05 and a 95% confidence interval of (-0.024-0.144) were found. The use of doses greater than 2 grams of IV vancomycin did not show a statistically significance increase in serum creatinine. The two subjects who did have a significant increase in serum creatinine were receiving concomitant nephrotoxins. Conclusion: The use of doses greater than 2 grams of IV vancomycin did not show a statistically significant increase in serum creatinine. Patients whom serum creatinine increased were on other nephrotoxin agents that could have contributed to the acute kidney injury that was seen in these patients.PublishedN/A2016-09-30T05:54:56Z2016-09-30T05:54:56Z20142016-09-30Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0975–1491http://hdl.handle.net/10725/4461Mansour, H., Bush, J. A., Brito, M., Novotny, P., Courtney, C., Mustonen, J., & Towey, K. (2014). The effect of vancomycin doses greater than 2 grams on serum creatinine and vancomycin trough levels. International Journal of Pharmacy and Pharmaceutical Sciences, 6(8), 621-625.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttp://innovareacademics.in/journals/index.php/ijpps/article/view/2791enInternational Journal of Pharmacy and Pharmaceutical Sciencesinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/44612022-03-29T08:52:05Z |
| spellingShingle | The effect of vancomycin doses greater than 2 grams on serum creatinine and vancomycin trough levels Mansour, Hanine |
| status_str | publishedVersion |
| title | The effect of vancomycin doses greater than 2 grams on serum creatinine and vancomycin trough levels |
| title_full | The effect of vancomycin doses greater than 2 grams on serum creatinine and vancomycin trough levels |
| title_fullStr | The effect of vancomycin doses greater than 2 grams on serum creatinine and vancomycin trough levels |
| title_full_unstemmed | The effect of vancomycin doses greater than 2 grams on serum creatinine and vancomycin trough levels |
| title_short | The effect of vancomycin doses greater than 2 grams on serum creatinine and vancomycin trough levels |
| title_sort | The effect of vancomycin doses greater than 2 grams on serum creatinine and vancomycin trough levels |
| url | http://hdl.handle.net/10725/4461 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://innovareacademics.in/journals/index.php/ijpps/article/view/2791 |