Applications of Zr-Catalyzed Carbomagnesation and Mo-Catalyzed Macrocyclic Ring Closing Metathesis in Asymmetric Synthesis. Enantioselective Total Synthesis of Sch 38516 (Fluvirucin B1)
The first enantioselective total synthesis of antifungal agent Sch 38516, also known as fluvirucin B1, is described. The synthesis includes a convergent asymmetric preparation of amine 17 and acid 18, which are then united to afford diene 62. Metal-catalyzed transformations play a crucial role in th...
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| Other Authors: | , , , , , |
| Format: | article |
| Published: |
1997
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| Online Access: | http://hdl.handle.net/10725/3303 http://dx.doi.org/10.1021/ja972191k http://pubs.acs.org/doi/abs/10.1021/ja972191k |
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