Choroidal vascular occlusion in a child with a connective tissue disease and complement C4 deficiency
Objective To report the histopathologic findings in the eyes of a patient with a connective tissue disease and complement deficiency. Design Human postmortem ocular histopathologic study. Intervention A 15-year-old female died from complications of a connective tissue disease of uncertain etiology,...
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2002
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| Online Access: | http://hdl.handle.net/10725/10869 https://doi.org/10.1016/S0161-6420(02)01080-1 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.sciencedirect.com/science/article/pii/S0161642002010801 |
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| _version_ | 1864513487519088641 |
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| author | Ghazi, Nicola G. |
| author2 | Gollance, Stephen A. Green, W. Richard |
| author2_role | author author |
| author_facet | Ghazi, Nicola G. Gollance, Stephen A. Green, W. Richard |
| author_role | author |
| dc.creator.none.fl_str_mv | Ghazi, Nicola G. Gollance, Stephen A. Green, W. Richard |
| dc.date.none.fl_str_mv | 2002 2019-06-20T10:12:13Z 2019-06-20T10:12:13Z 2019-06-20 |
| dc.identifier.none.fl_str_mv | 0161-6420 http://hdl.handle.net/10725/10869 https://doi.org/10.1016/S0161-6420(02)01080-1 Ghazi, N. G., Gollance, S. A., & Green, W. R. (2002). Choroidal vascular occlusion in a child with a connective tissue disease and complement C4 deficiency. Ophthalmology, 109(7), 1272-1277. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.sciencedirect.com/science/article/pii/S0161642002010801 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Ophthalmology |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Choroidal vascular occlusion in a child with a connective tissue disease and complement C4 deficiency |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Objective To report the histopathologic findings in the eyes of a patient with a connective tissue disease and complement deficiency. Design Human postmortem ocular histopathologic study. Intervention A 15-year-old female died from complications of a connective tissue disease of uncertain etiology, particularly acute respiratory distress syndrome. Abnormalities seen in the eyes at autopsy were consistent with complement activation, granulocyte aggregation, and leukocyte embolization. Main outcome measures Both eyes were examined by light microscopy. Results Some choroidal vessels were occluded by platelet–fibrin thrombi and occasionally by aggregates of granulocytes and fibrin. Serous retinal detachment involving the macula and peripheral retina was present in both eyes. Conclusions This is a report of the ocular histopathologic findings in a patient with connective tissue disease and complement C4 deficiency. The light microscopy findings were consistent with complement activation with granulocyte aggregation and leukocyte embolization and may represent another mechanism to explain the clinical findings in patients with connective tissue disease, particularly systemic lupus erythematosus. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_4e02c3305e5b1908560385ceffe1f97e |
| identifier_str_mv | 0161-6420 Ghazi, N. G., Gollance, S. A., & Green, W. R. (2002). Choroidal vascular occlusion in a child with a connective tissue disease and complement C4 deficiency. Ophthalmology, 109(7), 1272-1277. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/10869 |
| publishDate | 2002 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Choroidal vascular occlusion in a child with a connective tissue disease and complement C4 deficiencyGhazi, Nicola G.Gollance, Stephen A.Green, W. RichardObjective To report the histopathologic findings in the eyes of a patient with a connective tissue disease and complement deficiency. Design Human postmortem ocular histopathologic study. Intervention A 15-year-old female died from complications of a connective tissue disease of uncertain etiology, particularly acute respiratory distress syndrome. Abnormalities seen in the eyes at autopsy were consistent with complement activation, granulocyte aggregation, and leukocyte embolization. Main outcome measures Both eyes were examined by light microscopy. Results Some choroidal vessels were occluded by platelet–fibrin thrombi and occasionally by aggregates of granulocytes and fibrin. Serous retinal detachment involving the macula and peripheral retina was present in both eyes. Conclusions This is a report of the ocular histopathologic findings in a patient with connective tissue disease and complement C4 deficiency. The light microscopy findings were consistent with complement activation with granulocyte aggregation and leukocyte embolization and may represent another mechanism to explain the clinical findings in patients with connective tissue disease, particularly systemic lupus erythematosus.PublishedN/A2019-06-20T10:12:13Z2019-06-20T10:12:13Z20022019-06-20Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0161-6420http://hdl.handle.net/10725/10869https://doi.org/10.1016/S0161-6420(02)01080-1Ghazi, N. G., Gollance, S. A., & Green, W. R. (2002). Choroidal vascular occlusion in a child with a connective tissue disease and complement C4 deficiency. Ophthalmology, 109(7), 1272-1277.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://www.sciencedirect.com/science/article/pii/S0161642002010801enOphthalmologyinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/108692021-03-19T10:45:17Z |
| spellingShingle | Choroidal vascular occlusion in a child with a connective tissue disease and complement C4 deficiency Ghazi, Nicola G. |
| status_str | publishedVersion |
| title | Choroidal vascular occlusion in a child with a connective tissue disease and complement C4 deficiency |
| title_full | Choroidal vascular occlusion in a child with a connective tissue disease and complement C4 deficiency |
| title_fullStr | Choroidal vascular occlusion in a child with a connective tissue disease and complement C4 deficiency |
| title_full_unstemmed | Choroidal vascular occlusion in a child with a connective tissue disease and complement C4 deficiency |
| title_short | Choroidal vascular occlusion in a child with a connective tissue disease and complement C4 deficiency |
| title_sort | Choroidal vascular occlusion in a child with a connective tissue disease and complement C4 deficiency |
| url | http://hdl.handle.net/10725/10869 https://doi.org/10.1016/S0161-6420(02)01080-1 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.sciencedirect.com/science/article/pii/S0161642002010801 |