Curing hepatocellular carcinomatosis with biologic therapy and surgery

Hepatocellular carcinoma (HCC) that present as hemoperitoneum are uncommon, often recur as peritoneal carcinomatosis, and have poor prognosis. Systemic chemotherapies are minimally effective in advanced HCC and less so as neo-adjuvant therapy. This report describes a 47-year woman with ruptured HCC...

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Bibliographic Details
Main Author: Thomas, Melanie (author)
Other Authors: Tetzlaff, Eric (author), Lozano, Richard (author), Samp, Leigh (author), Butler, Charles (author), Gannon, Christopher (author), Hamilton, Stanley (author), Vauthey, Jean-Nicolas (author), Abdalla, Eddie (author)
Format: article
Published: 2008
Online Access:http://hdl.handle.net/10725/2593
http://dx.doi.org/10.1002/jso.2089
http://onlinelibrary.wiley.com/doi/10.1002/jso.20898/full
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Summary:Hepatocellular carcinoma (HCC) that present as hemoperitoneum are uncommon, often recur as peritoneal carcinomatosis, and have poor prognosis. Systemic chemotherapies are minimally effective in advanced HCC and less so as neo-adjuvant therapy. This report describes a 47-year woman with ruptured HCC who developed recurrent carcinomatosis. She received biologically targeted systemic therapy which resulted in significant radiographic tumor response. Salvage surgery revealed complete pathologic response in all tumor nodules, thus the patient was rendered cancer-free. J. Surg. Oncol. 2008;97:82–84. © 2007 Wiley-Liss, Inc.