Endobronchial ultrasound-guided transbronchial needle aspiration use for subclassification and genotyping of lung non-small-cell carcinoma
OBJECTIVES:Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is the primary method for the diagnosis and staging of lung cancer. The purpose of this study was to assess the yield of EBUS-TBNA in the subtyping and genotyping of lung adenocarcinoma. METHODS:Sixty-nine patien...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , |
| التنسيق: | article |
| منشور في: |
2018
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/10516 http://dx.doi.org/10.14423/SMJ.0000000000000846 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://sma.org/southern-medical-journal/article/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-use-for-subclassification-and-genotyping-of-lung-non-small-cell-carcinoma/ |
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| _version_ | 1864513486670790656 |
|---|---|
| author | Diab, Khalil |
| author2 | Raad, Samih Hanna, Nasser Jalal, Shadia Bendaly, Edmond Zhang, Chen Nuguru, Shashank Oueini, Houssam |
| author2_role | author author author author author author author |
| author_facet | Diab, Khalil Raad, Samih Hanna, Nasser Jalal, Shadia Bendaly, Edmond Zhang, Chen Nuguru, Shashank Oueini, Houssam |
| author_role | author |
| dc.creator.none.fl_str_mv | Diab, Khalil Raad, Samih Hanna, Nasser Jalal, Shadia Bendaly, Edmond Zhang, Chen Nuguru, Shashank Oueini, Houssam |
| dc.date.none.fl_str_mv | 2018 2019-05-02T08:25:19Z 2019-05-02T08:25:19Z 2019-05-02 |
| dc.identifier.none.fl_str_mv | 1541-8243 http://hdl.handle.net/10725/10516 http://dx.doi.org/10.14423/SMJ.0000000000000846 Raad, S., Hanna, N., Jalal, S., Bendaly, E., Zhang, C., Nuguru, S., ... & Diab, K. (2018). Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration Use for Subclassification and Genotyping of Lung Non-Small-Cell Carcinoma. Southern medical journal, 111(8), 484-488. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://sma.org/southern-medical-journal/article/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-use-for-subclassification-and-genotyping-of-lung-non-small-cell-carcinoma/ |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Southern Medical Journal |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Endobronchial ultrasound-guided transbronchial needle aspiration use for subclassification and genotyping of lung non-small-cell carcinoma |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | OBJECTIVES:Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is the primary method for the diagnosis and staging of lung cancer. The purpose of this study was to assess the yield of EBUS-TBNA in the subtyping and genotyping of lung adenocarcinoma. METHODS:Sixty-nine patients at Indiana University Hospital and Sidney and Lois Eskenazi Hospital with possible or confirmed lung adenocarcinoma underwent EBUS-TBNA using a 21-gauge Olympus needle without suction. Samples were sent for molecular testing after rapid onsite specimen evaluation. A total of 6 to 10 passes were placed in a cell block. RESULTS:Sixty-nine samples from patients with non-small-cell lung cancer were sent for molecular testing for epidermal growth factor receptor. Results were obtained in all of the patients. Mutations were found in three patients (4.3%). Fifty-eight samples were sent for V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (100% yield), 10 of which had mutations (17.2%). Fifty-one samples were sent for proto-oncogene tyrosine-protein kinase ROS testing (1 [7.8%] mutant). Tissue samples were inadequate in three patients (94.1% yield). Sixty-three samples were sent for anaplastic lymphoma receptor tyrosine kinase testing (3 [4.8%] mutant, 6 [9.5%] inadequate, 90.5% yield). CONCLUSIONS:EBUS-TBNA with a 21-gauge needle is appropriate for the analysis of multiple mutations and the genotyping of lung adenocarcinoma. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_4e61364646f1e19bb63f233886a74b4a |
| identifier_str_mv | 1541-8243 Raad, S., Hanna, N., Jalal, S., Bendaly, E., Zhang, C., Nuguru, S., ... & Diab, K. (2018). Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration Use for Subclassification and Genotyping of Lung Non-Small-Cell Carcinoma. Southern medical journal, 111(8), 484-488. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/10516 |
| publishDate | 2018 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Endobronchial ultrasound-guided transbronchial needle aspiration use for subclassification and genotyping of lung non-small-cell carcinomaDiab, KhalilRaad, SamihHanna, NasserJalal, ShadiaBendaly, EdmondZhang, ChenNuguru, ShashankOueini, HoussamOBJECTIVES:Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is the primary method for the diagnosis and staging of lung cancer. The purpose of this study was to assess the yield of EBUS-TBNA in the subtyping and genotyping of lung adenocarcinoma. METHODS:Sixty-nine patients at Indiana University Hospital and Sidney and Lois Eskenazi Hospital with possible or confirmed lung adenocarcinoma underwent EBUS-TBNA using a 21-gauge Olympus needle without suction. Samples were sent for molecular testing after rapid onsite specimen evaluation. A total of 6 to 10 passes were placed in a cell block. RESULTS:Sixty-nine samples from patients with non-small-cell lung cancer were sent for molecular testing for epidermal growth factor receptor. Results were obtained in all of the patients. Mutations were found in three patients (4.3%). Fifty-eight samples were sent for V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (100% yield), 10 of which had mutations (17.2%). Fifty-one samples were sent for proto-oncogene tyrosine-protein kinase ROS testing (1 [7.8%] mutant). Tissue samples were inadequate in three patients (94.1% yield). Sixty-three samples were sent for anaplastic lymphoma receptor tyrosine kinase testing (3 [4.8%] mutant, 6 [9.5%] inadequate, 90.5% yield). CONCLUSIONS:EBUS-TBNA with a 21-gauge needle is appropriate for the analysis of multiple mutations and the genotyping of lung adenocarcinoma.PublishedN/A2019-05-02T08:25:19Z2019-05-02T08:25:19Z20182019-05-02Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1541-8243http://hdl.handle.net/10725/10516http://dx.doi.org/10.14423/SMJ.0000000000000846Raad, S., Hanna, N., Jalal, S., Bendaly, E., Zhang, C., Nuguru, S., ... & Diab, K. (2018). Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration Use for Subclassification and Genotyping of Lung Non-Small-Cell Carcinoma. Southern medical journal, 111(8), 484-488.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttp://sma.org/southern-medical-journal/article/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-use-for-subclassification-and-genotyping-of-lung-non-small-cell-carcinoma/enSouthern Medical Journalinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/105162021-03-19T10:45:22Z |
| spellingShingle | Endobronchial ultrasound-guided transbronchial needle aspiration use for subclassification and genotyping of lung non-small-cell carcinoma Diab, Khalil |
| status_str | publishedVersion |
| title | Endobronchial ultrasound-guided transbronchial needle aspiration use for subclassification and genotyping of lung non-small-cell carcinoma |
| title_full | Endobronchial ultrasound-guided transbronchial needle aspiration use for subclassification and genotyping of lung non-small-cell carcinoma |
| title_fullStr | Endobronchial ultrasound-guided transbronchial needle aspiration use for subclassification and genotyping of lung non-small-cell carcinoma |
| title_full_unstemmed | Endobronchial ultrasound-guided transbronchial needle aspiration use for subclassification and genotyping of lung non-small-cell carcinoma |
| title_short | Endobronchial ultrasound-guided transbronchial needle aspiration use for subclassification and genotyping of lung non-small-cell carcinoma |
| title_sort | Endobronchial ultrasound-guided transbronchial needle aspiration use for subclassification and genotyping of lung non-small-cell carcinoma |
| url | http://hdl.handle.net/10725/10516 http://dx.doi.org/10.14423/SMJ.0000000000000846 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://sma.org/southern-medical-journal/article/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-use-for-subclassification-and-genotyping-of-lung-non-small-cell-carcinoma/ |