Circulating lipid levels and risk of coronary artery disease in a large group of patients undergoing coronary angiography
A main underlying pathology of coronary artery disease is the deposition of cholesterol in the arteries supplying blood to the heart that leads to stenosis and myocardial infarction. We tested if dyslipidemia is a risk factor for coronary artery disease in the Lebanese population, and studied the ro...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , , , |
| التنسيق: | article |
| منشور في: |
2015
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/4844 http://dx.doi.org/10.1007/s11239-014-1069-2 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://link.springer.com/article/10.1007/s11239-014-1069-2 |
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| _version_ | 1864513464630771712 |
|---|---|
| author | Deeb, Mary E. |
| author2 | Khazen, Georges Zalloua, Pierre A. Platt, Daniel E. Ghassibe-Sabbagh, Michella Cazier, Jean-Baptiste Kamatani, Yoichiro Salloum, Angelique K. Hager, Jo¨rg Youhanna, Sonia |
| author2_role | author author author author author author author author author |
| author_facet | Deeb, Mary E. Khazen, Georges Zalloua, Pierre A. Platt, Daniel E. Ghassibe-Sabbagh, Michella Cazier, Jean-Baptiste Kamatani, Yoichiro Salloum, Angelique K. Hager, Jo¨rg Youhanna, Sonia |
| author_role | author |
| dc.creator.none.fl_str_mv | Deeb, Mary E. Khazen, Georges Zalloua, Pierre A. Platt, Daniel E. Ghassibe-Sabbagh, Michella Cazier, Jean-Baptiste Kamatani, Yoichiro Salloum, Angelique K. Hager, Jo¨rg Youhanna, Sonia |
| dc.date.none.fl_str_mv | 2015 2016-11-23T14:24:32Z 2016-11-23T14:24:32Z 2016-11-23 |
| dc.identifier.none.fl_str_mv | 0929-5305 http://hdl.handle.net/10725/4844 http://dx.doi.org/10.1007/s11239-014-1069-2 Platt, D. E., Ghassibe-Sabbagh, M., Youhanna, S., Hager, J., Cazier, J. B., Kamatani, Y., ... & Mouzaya, F. (2015). Circulating lipid levels and risk of coronary artery disease in a large group of patients undergoing coronary angiography. Journal of thrombosis and thrombolysis, 39(1), 15-22. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://link.springer.com/article/10.1007/s11239-014-1069-2 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Journal of Thrombosis and Thrombolysis |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Circulating lipid levels and risk of coronary artery disease in a large group of patients undergoing coronary angiography |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | A main underlying pathology of coronary artery disease is the deposition of cholesterol in the arteries supplying blood to the heart that leads to stenosis and myocardial infarction. We tested if dyslipidemia is a risk factor for coronary artery disease in the Lebanese population, and studied the role of the total cholesterol/HDL cholesterol (TC/HDL-C) ratio as a biological marker of coronary artery disease. We recruited 6,180 Lebanese patients undergoing cardiac catheterization. We conducted a cross-sectional association study between TC/HDL-C ratio and the number and type of vessels occluded in catheterized patients by controlling for confounding effects. The TC/HDL-C ratio ≥4 significantly predicts ≥50 % stenosis in all vessels individually with the odds ratio (OR) ranging from 1.22 to 1.92. The OR increased with increasing number of ≥50 % stenotic vessels (1.39 for 2 vessels and 1.64 for 3–4 vessels), as did risk due to diabetes, CAD family history, gender, and age. The younger than average age of onset subgroup shows a pronounced increase in risk for occlusion of the left main coronary artery due to TC/HDL-C ≥4 (OR 3.26). In conclusion, low levels of HDL-cholesterol and high levels TC/HDL-C ratio are strong biological markers of disease occurrence and severity in the Lebanese population. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_4f2ccf11ce38065eea333afecd4abcfb |
| identifier_str_mv | 0929-5305 Platt, D. E., Ghassibe-Sabbagh, M., Youhanna, S., Hager, J., Cazier, J. B., Kamatani, Y., ... & Mouzaya, F. (2015). Circulating lipid levels and risk of coronary artery disease in a large group of patients undergoing coronary angiography. Journal of thrombosis and thrombolysis, 39(1), 15-22. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/4844 |
| publishDate | 2015 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Circulating lipid levels and risk of coronary artery disease in a large group of patients undergoing coronary angiographyDeeb, Mary E.Khazen, GeorgesZalloua, Pierre A.Platt, Daniel E.Ghassibe-Sabbagh, MichellaCazier, Jean-BaptisteKamatani, YoichiroSalloum, Angelique K.Hager, Jo¨rgYouhanna, SoniaA main underlying pathology of coronary artery disease is the deposition of cholesterol in the arteries supplying blood to the heart that leads to stenosis and myocardial infarction. We tested if dyslipidemia is a risk factor for coronary artery disease in the Lebanese population, and studied the role of the total cholesterol/HDL cholesterol (TC/HDL-C) ratio as a biological marker of coronary artery disease. We recruited 6,180 Lebanese patients undergoing cardiac catheterization. We conducted a cross-sectional association study between TC/HDL-C ratio and the number and type of vessels occluded in catheterized patients by controlling for confounding effects. The TC/HDL-C ratio ≥4 significantly predicts ≥50 % stenosis in all vessels individually with the odds ratio (OR) ranging from 1.22 to 1.92. The OR increased with increasing number of ≥50 % stenotic vessels (1.39 for 2 vessels and 1.64 for 3–4 vessels), as did risk due to diabetes, CAD family history, gender, and age. The younger than average age of onset subgroup shows a pronounced increase in risk for occlusion of the left main coronary artery due to TC/HDL-C ≥4 (OR 3.26). In conclusion, low levels of HDL-cholesterol and high levels TC/HDL-C ratio are strong biological markers of disease occurrence and severity in the Lebanese population.PublishedN/A2016-11-23T14:24:32Z2016-11-23T14:24:32Z20152016-11-23Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0929-5305http://hdl.handle.net/10725/4844http://dx.doi.org/10.1007/s11239-014-1069-2Platt, D. E., Ghassibe-Sabbagh, M., Youhanna, S., Hager, J., Cazier, J. B., Kamatani, Y., ... & Mouzaya, F. (2015). Circulating lipid levels and risk of coronary artery disease in a large group of patients undergoing coronary angiography. Journal of thrombosis and thrombolysis, 39(1), 15-22.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttp://link.springer.com/article/10.1007/s11239-014-1069-2enJournal of Thrombosis and Thrombolysisinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/48442021-03-19T10:03:21Z |
| spellingShingle | Circulating lipid levels and risk of coronary artery disease in a large group of patients undergoing coronary angiography Deeb, Mary E. |
| status_str | publishedVersion |
| title | Circulating lipid levels and risk of coronary artery disease in a large group of patients undergoing coronary angiography |
| title_full | Circulating lipid levels and risk of coronary artery disease in a large group of patients undergoing coronary angiography |
| title_fullStr | Circulating lipid levels and risk of coronary artery disease in a large group of patients undergoing coronary angiography |
| title_full_unstemmed | Circulating lipid levels and risk of coronary artery disease in a large group of patients undergoing coronary angiography |
| title_short | Circulating lipid levels and risk of coronary artery disease in a large group of patients undergoing coronary angiography |
| title_sort | Circulating lipid levels and risk of coronary artery disease in a large group of patients undergoing coronary angiography |
| url | http://hdl.handle.net/10725/4844 http://dx.doi.org/10.1007/s11239-014-1069-2 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://link.springer.com/article/10.1007/s11239-014-1069-2 |