Clinical and Prognostic Implications of Plasma Insulin-Like Growth Factor-1 and Vascular Endothelial Growth Factor in Patients With Hepatocellular Carcinoma
Purpose Cirrhosis and hepatocellular carcinoma (HCC) together form a two-disease state that affects survival of patients with HCC and dictates treatment decisions and prognostic stratification of patients in clinical trials. The study objective was to improve prognostic stratification of patients wi...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , , , , |
| التنسيق: | article |
| منشور في: |
2011
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/2633 http://dx.doi.org/10.1200/JCO.2011.36.0636 https://ascopubs.org/doi/full/10.1200/JCO.2011.36.0636 |
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| _version_ | 1864513459003064320 |
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| author | Kaseb, Ahmed O. |
| author2 | Morris, Jeffrey S. Hassan, Manal M. Siddiqui, Adnan M. Lin, E. Xiao, Lianchun Abdalla, Eddie K. Vauthey, Jean-Nicolas Aloia, Thomas A. Krishnan, Sunil Abbruzzese, James L. |
| author2_role | author author author author author author author author author author |
| author_facet | Kaseb, Ahmed O. Morris, Jeffrey S. Hassan, Manal M. Siddiqui, Adnan M. Lin, E. Xiao, Lianchun Abdalla, Eddie K. Vauthey, Jean-Nicolas Aloia, Thomas A. Krishnan, Sunil Abbruzzese, James L. |
| author_role | author |
| dc.creator.none.fl_str_mv | Kaseb, Ahmed O. Morris, Jeffrey S. Hassan, Manal M. Siddiqui, Adnan M. Lin, E. Xiao, Lianchun Abdalla, Eddie K. Vauthey, Jean-Nicolas Aloia, Thomas A. Krishnan, Sunil Abbruzzese, James L. |
| dc.date.none.fl_str_mv | 2011 2011-09-12 2015-11-19T13:43:42Z 2015-11-19T13:43:42Z |
| dc.identifier.none.fl_str_mv | 0732-183X http://hdl.handle.net/10725/2633 http://dx.doi.org/10.1200/JCO.2011.36.0636 Kaseb, A. O., Morris, J. S., Hassan, M. M., Siddiqui, A. M., Lin, E., Xiao, L., ... & Abbruzzese, J. L. (2011). Clinical and prognostic implications of plasma insulin-like growth factor-1 and vascular endothelial growth factor in patients with hepatocellular carcinoma. Journal of clinical oncology, 29(29), 3892-3899. https://ascopubs.org/doi/full/10.1200/JCO.2011.36.0636 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Journal of Surgical Oncology |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Clinical and Prognostic Implications of Plasma Insulin-Like Growth Factor-1 and Vascular Endothelial Growth Factor in Patients With Hepatocellular Carcinoma |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Purpose Cirrhosis and hepatocellular carcinoma (HCC) together form a two-disease state that affects survival of patients with HCC and dictates treatment decisions and prognostic stratification of patients in clinical trials. The study objective was to improve prognostic stratification of patients with HCC. Patients and Methods We prospectively collected plasma samples and baseline clinicopathologic features from 288 new patients with HCC, and plasma insulin-like growth factor-1 (IGF-1) and vascular endothelial growth factor (VEGF) levels were tested. We applied Cox regression and log-rank tests to assess association of IGF-1 and VEGF with overall survival (OS), Kaplan-Meier curves to estimate OS, and recursive partitioning to determine optimal cutoff points for IGF-1 and VEGF. Prognostic ability of conventional and molecular Barcelona Clinic Liver Cancer classifications was compared using the c-index. Results Lower plasma IGF-1 and higher plasma VEGF levels significantly correlated with advanced clinicopathologic parameters and poor OS, with optimal cut points of 26 ng/mL and 450 pg/mL, respectively. The combination of low IGF-1 and high VEGF predicted median OS of 2.7 months compared with 19 months for patients with high IGF-1 and low VEGF (P < .001), further refining the prognostic ability of conventional HCC staging (P < .001). Conclusion Baseline levels of plasma IGF-1 and VEGF correlated significantly with survival in patients with HCC. Integrating IGF-1 and VEGF into HCC staging significantly enhanced prognostic stratification of patients. If validated, these results may prove to be useful in designing strategies to personalize management approaches among these patients. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_4ffd47a3ad5363df5b7a8b842854d7f6 |
| identifier_str_mv | 0732-183X Kaseb, A. O., Morris, J. S., Hassan, M. M., Siddiqui, A. M., Lin, E., Xiao, L., ... & Abbruzzese, J. L. (2011). Clinical and prognostic implications of plasma insulin-like growth factor-1 and vascular endothelial growth factor in patients with hepatocellular carcinoma. Journal of clinical oncology, 29(29), 3892-3899. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/2633 |
| publishDate | 2011 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Clinical and Prognostic Implications of Plasma Insulin-Like Growth Factor-1 and Vascular Endothelial Growth Factor in Patients With Hepatocellular CarcinomaKaseb, Ahmed O.Morris, Jeffrey S.Hassan, Manal M.Siddiqui, Adnan M.Lin, E.Xiao, LianchunAbdalla, Eddie K.Vauthey, Jean-NicolasAloia, Thomas A.Krishnan, SunilAbbruzzese, James L.Purpose Cirrhosis and hepatocellular carcinoma (HCC) together form a two-disease state that affects survival of patients with HCC and dictates treatment decisions and prognostic stratification of patients in clinical trials. The study objective was to improve prognostic stratification of patients with HCC. Patients and Methods We prospectively collected plasma samples and baseline clinicopathologic features from 288 new patients with HCC, and plasma insulin-like growth factor-1 (IGF-1) and vascular endothelial growth factor (VEGF) levels were tested. We applied Cox regression and log-rank tests to assess association of IGF-1 and VEGF with overall survival (OS), Kaplan-Meier curves to estimate OS, and recursive partitioning to determine optimal cutoff points for IGF-1 and VEGF. Prognostic ability of conventional and molecular Barcelona Clinic Liver Cancer classifications was compared using the c-index. Results Lower plasma IGF-1 and higher plasma VEGF levels significantly correlated with advanced clinicopathologic parameters and poor OS, with optimal cut points of 26 ng/mL and 450 pg/mL, respectively. The combination of low IGF-1 and high VEGF predicted median OS of 2.7 months compared with 19 months for patients with high IGF-1 and low VEGF (P < .001), further refining the prognostic ability of conventional HCC staging (P < .001). Conclusion Baseline levels of plasma IGF-1 and VEGF correlated significantly with survival in patients with HCC. Integrating IGF-1 and VEGF into HCC staging significantly enhanced prognostic stratification of patients. If validated, these results may prove to be useful in designing strategies to personalize management approaches among these patients.PublishedN/A2015-11-19T13:43:42Z2015-11-19T13:43:42Z20112011-09-12Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0732-183Xhttp://hdl.handle.net/10725/2633http://dx.doi.org/10.1200/JCO.2011.36.0636Kaseb, A. O., Morris, J. S., Hassan, M. M., Siddiqui, A. M., Lin, E., Xiao, L., ... & Abbruzzese, J. L. (2011). Clinical and prognostic implications of plasma insulin-like growth factor-1 and vascular endothelial growth factor in patients with hepatocellular carcinoma. Journal of clinical oncology, 29(29), 3892-3899.https://ascopubs.org/doi/full/10.1200/JCO.2011.36.0636enJournal of Surgical Oncologyinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/26332026-03-31T16:19:43Z |
| spellingShingle | Clinical and Prognostic Implications of Plasma Insulin-Like Growth Factor-1 and Vascular Endothelial Growth Factor in Patients With Hepatocellular Carcinoma Kaseb, Ahmed O. |
| status_str | publishedVersion |
| title | Clinical and Prognostic Implications of Plasma Insulin-Like Growth Factor-1 and Vascular Endothelial Growth Factor in Patients With Hepatocellular Carcinoma |
| title_full | Clinical and Prognostic Implications of Plasma Insulin-Like Growth Factor-1 and Vascular Endothelial Growth Factor in Patients With Hepatocellular Carcinoma |
| title_fullStr | Clinical and Prognostic Implications of Plasma Insulin-Like Growth Factor-1 and Vascular Endothelial Growth Factor in Patients With Hepatocellular Carcinoma |
| title_full_unstemmed | Clinical and Prognostic Implications of Plasma Insulin-Like Growth Factor-1 and Vascular Endothelial Growth Factor in Patients With Hepatocellular Carcinoma |
| title_short | Clinical and Prognostic Implications of Plasma Insulin-Like Growth Factor-1 and Vascular Endothelial Growth Factor in Patients With Hepatocellular Carcinoma |
| title_sort | Clinical and Prognostic Implications of Plasma Insulin-Like Growth Factor-1 and Vascular Endothelial Growth Factor in Patients With Hepatocellular Carcinoma |
| url | http://hdl.handle.net/10725/2633 http://dx.doi.org/10.1200/JCO.2011.36.0636 https://ascopubs.org/doi/full/10.1200/JCO.2011.36.0636 |