The Effect of Formulation Parameters on the Physical Properties and In-Vitro Dissolution Profile of Ethyl Cellulose-Theophylline Microspheres Using the Emulsion-Solvent Evaporation Process
Controlled-Release drug delivery using microspheres depends on drug-encapsulation formulation, processing conditions, and excipient physical properties. Several parameters affect the microspheres’ formation and properties, including Physical, Chemical, and dissolution profile. This thesis aims to ga...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| التنسيق: | masterThesis |
| منشور في: |
2020
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/13453 https://doi.org/10.26756/th.2022.329 http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513467837317120 |
|---|---|
| author | Rammal, Hassan A |
| author_facet | Rammal, Hassan A |
| author_role | author |
| dc.creator.none.fl_str_mv | Rammal, Hassan A |
| dc.date.none.fl_str_mv | 2020 2020-06-07 2022-04-05T12:49:10Z 2022-04-05T12:49:10Z |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10725/13453 https://doi.org/10.26756/th.2022.329 http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Lebanese American University |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Microspheres (Pharmacy) Drug delivery systems Microencapsulation Ethylcellulose Lebanese American University -- Dissertations Dissertations, Academic |
| dc.title.none.fl_str_mv | The Effect of Formulation Parameters on the Physical Properties and In-Vitro Dissolution Profile of Ethyl Cellulose-Theophylline Microspheres Using the Emulsion-Solvent Evaporation Process Nonionic Surfactant Structure and Concentration, Temperature and Solvent |
| dc.type.none.fl_str_mv | Thesis info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/masterThesis |
| description | Controlled-Release drug delivery using microspheres depends on drug-encapsulation formulation, processing conditions, and excipient physical properties. Several parameters affect the microspheres’ formation and properties, including Physical, Chemical, and dissolution profile. This thesis aims to gain a better understanding of the number and type of parameters which affect the properties of Ethyl-Cellulose-Theophylline microspheres, and also attempts to explain the reason why said parameter affects said property in a certain specific way. In order to fully explore by which means drug-encapsulated microspheres are affected, this thesis looked at eight different parameters which were suspected to trigger changes in the properties of microspheres. The final aim of this thesis was to develop the most effective, efficient, and environmentally friendly method to form microspheres possessing the most beneficial properties for controlled release drug delivery |
| eu_rights_str_mv | openAccess |
| format | masterThesis |
| id | LAURepo_5396db436dfeddd88a12016d1da714fc |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/13453 |
| publishDate | 2020 |
| publisher.none.fl_str_mv | Lebanese American University |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | The Effect of Formulation Parameters on the Physical Properties and In-Vitro Dissolution Profile of Ethyl Cellulose-Theophylline Microspheres Using the Emulsion-Solvent Evaporation ProcessNonionic Surfactant Structure and Concentration, Temperature and SolventRammal, Hassan AMicrospheres (Pharmacy)Drug delivery systemsMicroencapsulationEthylcelluloseLebanese American University -- DissertationsDissertations, AcademicControlled-Release drug delivery using microspheres depends on drug-encapsulation formulation, processing conditions, and excipient physical properties. Several parameters affect the microspheres’ formation and properties, including Physical, Chemical, and dissolution profile. This thesis aims to gain a better understanding of the number and type of parameters which affect the properties of Ethyl-Cellulose-Theophylline microspheres, and also attempts to explain the reason why said parameter affects said property in a certain specific way. In order to fully explore by which means drug-encapsulated microspheres are affected, this thesis looked at eight different parameters which were suspected to trigger changes in the properties of microspheres. The final aim of this thesis was to develop the most effective, efficient, and environmentally friendly method to form microspheres possessing the most beneficial properties for controlled release drug delivery1 online resource (xiii, 94 leaves) ; ill. (some col.)Includes bibliographical references (leaf 87-94)Lebanese American University2022-04-05T12:49:10Z2022-04-05T12:49:10Z20202020-06-07Thesisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesishttp://hdl.handle.net/10725/13453https://doi.org/10.26756/th.2022.329http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.phpeninfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/134532022-07-14T05:50:48Z |
| spellingShingle | The Effect of Formulation Parameters on the Physical Properties and In-Vitro Dissolution Profile of Ethyl Cellulose-Theophylline Microspheres Using the Emulsion-Solvent Evaporation Process Rammal, Hassan A Microspheres (Pharmacy) Drug delivery systems Microencapsulation Ethylcellulose Lebanese American University -- Dissertations Dissertations, Academic |
| status_str | publishedVersion |
| title | The Effect of Formulation Parameters on the Physical Properties and In-Vitro Dissolution Profile of Ethyl Cellulose-Theophylline Microspheres Using the Emulsion-Solvent Evaporation Process |
| title_full | The Effect of Formulation Parameters on the Physical Properties and In-Vitro Dissolution Profile of Ethyl Cellulose-Theophylline Microspheres Using the Emulsion-Solvent Evaporation Process |
| title_fullStr | The Effect of Formulation Parameters on the Physical Properties and In-Vitro Dissolution Profile of Ethyl Cellulose-Theophylline Microspheres Using the Emulsion-Solvent Evaporation Process |
| title_full_unstemmed | The Effect of Formulation Parameters on the Physical Properties and In-Vitro Dissolution Profile of Ethyl Cellulose-Theophylline Microspheres Using the Emulsion-Solvent Evaporation Process |
| title_short | The Effect of Formulation Parameters on the Physical Properties and In-Vitro Dissolution Profile of Ethyl Cellulose-Theophylline Microspheres Using the Emulsion-Solvent Evaporation Process |
| title_sort | The Effect of Formulation Parameters on the Physical Properties and In-Vitro Dissolution Profile of Ethyl Cellulose-Theophylline Microspheres Using the Emulsion-Solvent Evaporation Process |
| topic | Microspheres (Pharmacy) Drug delivery systems Microencapsulation Ethylcellulose Lebanese American University -- Dissertations Dissertations, Academic |
| url | http://hdl.handle.net/10725/13453 https://doi.org/10.26756/th.2022.329 http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php |