Magnetic property, DFT calculation, and biological activity of bis[(μ2-chloro)chloro(1,10-phenanthroline)copper(II)] complex
The dinuclear complex bis[(μ2-chloro)chloro(1,10-phenanthroline)copper(II)] (1) was synthesized, and characterized by X-ray, FTIR and thermal analysis. The fitting of magnetic susceptibility and magnetization curve of (1) indicates the occurrence of weak antiferromagnetic exchange interaction betwee...
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2015
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| Online Access: | http://hdl.handle.net/10725/2814 http://dx.doi.org/10.1016/j.cbi.2015.02.023 http://www.sciencedirect.com/science/article/pii/S0009279715000927 |
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| _version_ | 1864513459418300416 |
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| author | Mroueh, Mohammad |
| author2 | Daher, Costantine Hariri, Essa Demirdjian, Sally Isber, Samih Choi, Eun Sang Mirtamizdoust, Babak Hammud, Hassan H. |
| author2_role | author author author author author author author |
| author_facet | Mroueh, Mohammad Daher, Costantine Hariri, Essa Demirdjian, Sally Isber, Samih Choi, Eun Sang Mirtamizdoust, Babak Hammud, Hassan H. |
| author_role | author |
| dc.creator.none.fl_str_mv | Mroueh, Mohammad Daher, Costantine Hariri, Essa Demirdjian, Sally Isber, Samih Choi, Eun Sang Mirtamizdoust, Babak Hammud, Hassan H. |
| dc.date.none.fl_str_mv | 2015-12-16T07:43:29Z 2015-12-16T07:43:29Z 2015 2015-12-16 |
| dc.identifier.none.fl_str_mv | 0009-2797 http://hdl.handle.net/10725/2814 http://dx.doi.org/10.1016/j.cbi.2015.02.023 Mroueh, M., Daher, C., Hariri, E., Demirdjian, S., Isber, S., Choi, E. S., ... & Hammud, H. H. (2015). Magnetic property, DFT calculation, and biological activity of bis [(μ 2-chloro) chloro (1, 10-phenanthroline) copper (II)] complex. Chemico-biological interactions, 231, 53-60. http://www.sciencedirect.com/science/article/pii/S0009279715000927 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Chemico-Biological Interactions |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Magnetic property, DFT calculation, and biological activity of bis[(μ2-chloro)chloro(1,10-phenanthroline)copper(II)] complex |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | The dinuclear complex bis[(μ2-chloro)chloro(1,10-phenanthroline)copper(II)] (1) was synthesized, and characterized by X-ray, FTIR and thermal analysis. The fitting of magnetic susceptibility and magnetization curve of (1) indicates the occurrence of weak antiferromagnetic exchange interaction between copper(II) ions. The electronic structure has been also determined by density functional theory (DFT) method. Complex (1) displayed potent anticancer activity against B16 (Melanoma), MDA-MB-32 (Breast Adenocarcinoma), A549 (Lung Adenocarcinoma), HT-29 (Colon Adenocarcinoma) and SF (Astrocytoma) cell lines with an average IC50 value of 0.726 μg/ml compared to 4.88 μg/ml for cisplatin. Complex (1) has a better therapeutic index and toxicological profile than cisplatin, and has demonstrated a potential chemotherapeutic property. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_5604ef373bf5d1dc8091bf5d10a2d0bb |
| identifier_str_mv | 0009-2797 Mroueh, M., Daher, C., Hariri, E., Demirdjian, S., Isber, S., Choi, E. S., ... & Hammud, H. H. (2015). Magnetic property, DFT calculation, and biological activity of bis [(μ 2-chloro) chloro (1, 10-phenanthroline) copper (II)] complex. Chemico-biological interactions, 231, 53-60. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/2814 |
| publishDate | 2015 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Magnetic property, DFT calculation, and biological activity of bis[(μ2-chloro)chloro(1,10-phenanthroline)copper(II)] complexMroueh, MohammadDaher, CostantineHariri, EssaDemirdjian, SallyIsber, SamihChoi, Eun SangMirtamizdoust, BabakHammud, Hassan H.The dinuclear complex bis[(μ2-chloro)chloro(1,10-phenanthroline)copper(II)] (1) was synthesized, and characterized by X-ray, FTIR and thermal analysis. The fitting of magnetic susceptibility and magnetization curve of (1) indicates the occurrence of weak antiferromagnetic exchange interaction between copper(II) ions. The electronic structure has been also determined by density functional theory (DFT) method. Complex (1) displayed potent anticancer activity against B16 (Melanoma), MDA-MB-32 (Breast Adenocarcinoma), A549 (Lung Adenocarcinoma), HT-29 (Colon Adenocarcinoma) and SF (Astrocytoma) cell lines with an average IC50 value of 0.726 μg/ml compared to 4.88 μg/ml for cisplatin. Complex (1) has a better therapeutic index and toxicological profile than cisplatin, and has demonstrated a potential chemotherapeutic property.PublishedN/A2015-12-16T07:43:29Z2015-12-16T07:43:29Z20152015-12-16Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0009-2797http://hdl.handle.net/10725/2814http://dx.doi.org/10.1016/j.cbi.2015.02.023Mroueh, M., Daher, C., Hariri, E., Demirdjian, S., Isber, S., Choi, E. S., ... & Hammud, H. H. (2015). Magnetic property, DFT calculation, and biological activity of bis [(μ 2-chloro) chloro (1, 10-phenanthroline) copper (II)] complex. Chemico-biological interactions, 231, 53-60.http://www.sciencedirect.com/science/article/pii/S0009279715000927enChemico-Biological Interactionsinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/28142024-01-31T15:30:39Z |
| spellingShingle | Magnetic property, DFT calculation, and biological activity of bis[(μ2-chloro)chloro(1,10-phenanthroline)copper(II)] complex Mroueh, Mohammad |
| status_str | publishedVersion |
| title | Magnetic property, DFT calculation, and biological activity of bis[(μ2-chloro)chloro(1,10-phenanthroline)copper(II)] complex |
| title_full | Magnetic property, DFT calculation, and biological activity of bis[(μ2-chloro)chloro(1,10-phenanthroline)copper(II)] complex |
| title_fullStr | Magnetic property, DFT calculation, and biological activity of bis[(μ2-chloro)chloro(1,10-phenanthroline)copper(II)] complex |
| title_full_unstemmed | Magnetic property, DFT calculation, and biological activity of bis[(μ2-chloro)chloro(1,10-phenanthroline)copper(II)] complex |
| title_short | Magnetic property, DFT calculation, and biological activity of bis[(μ2-chloro)chloro(1,10-phenanthroline)copper(II)] complex |
| title_sort | Magnetic property, DFT calculation, and biological activity of bis[(μ2-chloro)chloro(1,10-phenanthroline)copper(II)] complex |
| url | http://hdl.handle.net/10725/2814 http://dx.doi.org/10.1016/j.cbi.2015.02.023 http://www.sciencedirect.com/science/article/pii/S0009279715000927 |