No association between the −1031 polymorphism in the TNF-α promoter region and type 1 diabetes
Tumor necrosis factor alpha (TNF-α) is an important immunomodulator and is believed to be involved in the development or progression of type 1 diabetes. In the following study, we evaluated TNF-α promoter polymorphisms at positions −863 and −1031 and their ass...
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| Other Authors: | , , , , |
| Format: | article |
| Published: |
2003
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| Online Access: | http://hdl.handle.net/10725/11109 https://doi.org/10.1016/S0198-8859(03)00053-3 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.sciencedirect.com/science/article/pii/S0198885903000533 |
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| Summary: | Tumor necrosis factor alpha (TNF-α) is an important immunomodulator and is believed to be involved in the development or progression of type 1 diabetes. In the following study, we evaluated TNF-α promoter polymorphisms at positions −863 and −1031 and their association with type 1 diabetes in a group of 210 diabetic patients from Lebanon. Our results show that in our population, the C allele is predominant at position −863, whereas the A allele is very rare (2%). At position −1031, however, the C and T allele distribution was similar in both the patient (17.8% vs 82.2%, respectively) and the control (21.4% vs 79.6%) groups. No association of TNF-α genotype at position 1031 with type 1 diabetes was found as demonstrated by the family-based association test and the transmission disequilibrium test. However, when patient genotypes were compared, the recessive CC genotype was only found in type 1 diabetic males but not in type 1 diabetic females. This observation, however, requires further investigation in a larger sample before conclusive association to gender is suggested. In conclusion, our results demonstrate that no association between TNF-α polymorphism and type 1 diabetes seems to exist in our population. |
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