Long-term antibiotic resistance surveillance of gram-negative pathogens suggests that temporal trends can be used as a resistance warning system
Antibiotic resistance among Gram-negative bacteria and antibiotic consumption were investigated at the Karolinska Hospital, Stockholm, Sweden over a 12-y period. The investigation showed an increase in ciprofloxacin resistance of Escherichia coli from 0% in 1991 to 7% in 1997 and to 11% in 1999. Res...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | , , , , , , |
| Format: | article |
| Published: |
2002
|
| Online Access: | http://hdl.handle.net/10725/10656 https://doi.org/10.1080/00365540110080287 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.tandfonline.com/doi/abs/10.1080/00365540110080287 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1864513487047229440 |
|---|---|
| author | Sorberg, Mikael |
| author2 | Farra, Anna Ransjo, Ulrika Gardlund, Bengt Rylander, Margareta Wallen, Leif Kalin, Mats Kronvall, Goran |
| author2_role | author author author author author author author |
| author_facet | Sorberg, Mikael Farra, Anna Ransjo, Ulrika Gardlund, Bengt Rylander, Margareta Wallen, Leif Kalin, Mats Kronvall, Goran |
| author_role | author |
| dc.creator.none.fl_str_mv | Sorberg, Mikael Farra, Anna Ransjo, Ulrika Gardlund, Bengt Rylander, Margareta Wallen, Leif Kalin, Mats Kronvall, Goran |
| dc.date.none.fl_str_mv | 2002 2019-05-23T10:30:42Z 2019-05-23T10:30:42Z 2019-05-23 |
| dc.identifier.none.fl_str_mv | 1651-1980 http://hdl.handle.net/10725/10656 https://doi.org/10.1080/00365540110080287 Sörberg, M., Farra, A., Ransjö, U., Gårdlund, B., Rylander, M., Wallén, L., ... & Kronvall, G. (2002). Long-term antibiotic resistance surveillance of Gram-negative pathogens suggests that temporal trends can be used as a resistance warning system. Scandinavian journal of infectious diseases, 34(5), 372-378. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.tandfonline.com/doi/abs/10.1080/00365540110080287 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Scandinavian Journal of Infectious Diseases |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Long-term antibiotic resistance surveillance of gram-negative pathogens suggests that temporal trends can be used as a resistance warning system |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Antibiotic resistance among Gram-negative bacteria and antibiotic consumption were investigated at the Karolinska Hospital, Stockholm, Sweden over a 12-y period. The investigation showed an increase in ciprofloxacin resistance of Escherichia coli from 0% in 1991 to 7% in 1997 and to 11% in 1999. Resistance among Pseudomonas aeruginosa isolates to ciprofloxacin increased from 2.5% in 1991 to 9.0% in 1997 and to 13% in 1999. Resistance levels for norfloxacin showed the same high statistical significance in terms of the temporal trend. A more detailed analysis showed higher resistance against norfloxacin in specific wards. Relationships between antibiotic use and antibiotic susceptibility showed different patterns. The increased ciprofloxacin resistance of E. coli and P. aeruginosa during the study period was paralleled by an increased consumption of quinolones. During the 12-y study period the total use of cephalosporins increased 2.5-fold, while the levels of E. coli resistance to cefuroxime and cefotaxime remained stable. A third pattern was seen with trimethoprim-sulfamethoxazole, namely increasing resistance of E. coli as the use of trimethoprim-sulfamethoxazole declined. The analysis of resistance levels and antibiotic consumption in the present study suggests different mechanisms for the increased resistance. The significant trend of increased resistance to antibiotics over time constitutes an important warning system. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_5b1c96e9afc9f93c2f4ee2a7a9fb98c9 |
| identifier_str_mv | 1651-1980 Sörberg, M., Farra, A., Ransjö, U., Gårdlund, B., Rylander, M., Wallén, L., ... & Kronvall, G. (2002). Long-term antibiotic resistance surveillance of Gram-negative pathogens suggests that temporal trends can be used as a resistance warning system. Scandinavian journal of infectious diseases, 34(5), 372-378. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/10656 |
| publishDate | 2002 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Long-term antibiotic resistance surveillance of gram-negative pathogens suggests that temporal trends can be used as a resistance warning systemSorberg, MikaelFarra, AnnaRansjo, UlrikaGardlund, BengtRylander, MargaretaWallen, LeifKalin, MatsKronvall, GoranAntibiotic resistance among Gram-negative bacteria and antibiotic consumption were investigated at the Karolinska Hospital, Stockholm, Sweden over a 12-y period. The investigation showed an increase in ciprofloxacin resistance of Escherichia coli from 0% in 1991 to 7% in 1997 and to 11% in 1999. Resistance among Pseudomonas aeruginosa isolates to ciprofloxacin increased from 2.5% in 1991 to 9.0% in 1997 and to 13% in 1999. Resistance levels for norfloxacin showed the same high statistical significance in terms of the temporal trend. A more detailed analysis showed higher resistance against norfloxacin in specific wards. Relationships between antibiotic use and antibiotic susceptibility showed different patterns. The increased ciprofloxacin resistance of E. coli and P. aeruginosa during the study period was paralleled by an increased consumption of quinolones. During the 12-y study period the total use of cephalosporins increased 2.5-fold, while the levels of E. coli resistance to cefuroxime and cefotaxime remained stable. A third pattern was seen with trimethoprim-sulfamethoxazole, namely increasing resistance of E. coli as the use of trimethoprim-sulfamethoxazole declined. The analysis of resistance levels and antibiotic consumption in the present study suggests different mechanisms for the increased resistance. The significant trend of increased resistance to antibiotics over time constitutes an important warning system.PublishedN/A2019-05-23T10:30:42Z2019-05-23T10:30:42Z20022019-05-23Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1651-1980http://hdl.handle.net/10725/10656https://doi.org/10.1080/00365540110080287Sörberg, M., Farra, A., Ransjö, U., Gårdlund, B., Rylander, M., Wallén, L., ... & Kronvall, G. (2002). Long-term antibiotic resistance surveillance of Gram-negative pathogens suggests that temporal trends can be used as a resistance warning system. Scandinavian journal of infectious diseases, 34(5), 372-378.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://www.tandfonline.com/doi/abs/10.1080/00365540110080287enScandinavian Journal of Infectious Diseasesinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/106562021-03-19T10:45:19Z |
| spellingShingle | Long-term antibiotic resistance surveillance of gram-negative pathogens suggests that temporal trends can be used as a resistance warning system Sorberg, Mikael |
| status_str | publishedVersion |
| title | Long-term antibiotic resistance surveillance of gram-negative pathogens suggests that temporal trends can be used as a resistance warning system |
| title_full | Long-term antibiotic resistance surveillance of gram-negative pathogens suggests that temporal trends can be used as a resistance warning system |
| title_fullStr | Long-term antibiotic resistance surveillance of gram-negative pathogens suggests that temporal trends can be used as a resistance warning system |
| title_full_unstemmed | Long-term antibiotic resistance surveillance of gram-negative pathogens suggests that temporal trends can be used as a resistance warning system |
| title_short | Long-term antibiotic resistance surveillance of gram-negative pathogens suggests that temporal trends can be used as a resistance warning system |
| title_sort | Long-term antibiotic resistance surveillance of gram-negative pathogens suggests that temporal trends can be used as a resistance warning system |
| url | http://hdl.handle.net/10725/10656 https://doi.org/10.1080/00365540110080287 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.tandfonline.com/doi/abs/10.1080/00365540110080287 |