Obesity as a risk factor for sedation-related complications during propofol-mediated sedation for advanced endoscopic procedures
Background There are limited data on the safety of anesthesia-assisted endoscopy by using propofol-mediated sedation in obese individuals undergoing advanced endoscopic procedures (AEPs). Objective To study the association between obesity (as measured by body mass index [BMI]) and the frequency of s...
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2011
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| Online Access: | http://hdl.handle.net/10725/4269 http://dx.doi.org/10.1016/j.gie.2011.09.006 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.sciencedirect.com/science/article/pii/S0016510711021766 |
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| _version_ | 1864513463190028288 |
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| author | Azar, Riad |
| author2 | Wani, Sachin Hovis, Christine E. Hovis, Robert M. Cote, Gregory A. Hall, Matthew Waldbaum, Lawrence |
| author2_role | author author author author author author |
| author_facet | Azar, Riad Wani, Sachin Hovis, Christine E. Hovis, Robert M. Cote, Gregory A. Hall, Matthew Waldbaum, Lawrence |
| author_role | author |
| dc.creator.none.fl_str_mv | Azar, Riad Wani, Sachin Hovis, Christine E. Hovis, Robert M. Cote, Gregory A. Hall, Matthew Waldbaum, Lawrence |
| dc.date.none.fl_str_mv | 2011 2016-09-09T13:33:56Z 2016-09-09T13:33:56Z 2016-09-09 |
| dc.identifier.none.fl_str_mv | 0016-5107 http://hdl.handle.net/10725/4269 http://dx.doi.org/10.1016/j.gie.2011.09.006 Wani, S., Azar, R., Hovis, C. E., Hovis, R. M., Cote, G. A., Hall, M., ... & Murad, F. (2011). Obesity as a risk factor for sedation-related complications during propofol-mediated sedation for advanced endoscopic procedures. Gastrointestinal endoscopy, 74(6), 1238-1247. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.sciencedirect.com/science/article/pii/S0016510711021766 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Gastrointestinal Endoscopy |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Obesity as a risk factor for sedation-related complications during propofol-mediated sedation for advanced endoscopic procedures |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Background There are limited data on the safety of anesthesia-assisted endoscopy by using propofol-mediated sedation in obese individuals undergoing advanced endoscopic procedures (AEPs). Objective To study the association between obesity (as measured by body mass index [BMI]) and the frequency of sedation-related complications (SRCs) in patients undergoing AEPs. Design Prospective cohort study. Setting Tertiary referral center. Patients A total of 1016 consecutive patients undergoing AEPs (BMI <30, 730 [72%]; 30-35, 159 [16%]; >35, 127 [12%]). Intervention Monitored anesthesia sedation with propofol alone or in combination with benzodiazepines and/or opioids. Main Outcome Measurements SRCs, airway maneuvers (AMs), hypoxemia, hypotension requiring vasopressors, and early procedure termination were compared across 3 groups. Results There were 203 AMs in 13.9% of patients, hypoxemia in 7.3%, need for vasopressors in 0.8%, and premature termination in 0.6% of patients. Increasing BMI was associated with an increased frequency of AMs (BMI <30, 10.5%; 30-35, 18.9%; >35–26.8%; P < .001) and hypoxemia (BMI <30, 5.3%; 30-35, 9.4%; >35, 13.4%; P = .001); there was no difference in the frequency of need for vasopressors (P = .254) and premature termination of procedures (P = .401). On multivariable analysis, BMI (odds ratio [OR] 2.0; 95% CI, 1.3-3.1), age (OR 1.1; 95% CI, 1.0-1.1), and American Society of Anesthesiologists class 3 or higher (OR 2.4; 95% CI, 1.1-5.0) were independent predictors of SRCs. In obese individuals (n = 286), there was no difference in the frequency of SRCs in patients receiving propofol alone or in combination (P = .48). Limitations Single tertiary center study. Conclusions Although obesity was associated with an increased frequency of SRCs, propofol sedation can be used safely in obese patients undergoing AEPs when administered by trained professionals. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_5b2d129f0465ce927867f4c45e6519ea |
| identifier_str_mv | 0016-5107 Wani, S., Azar, R., Hovis, C. E., Hovis, R. M., Cote, G. A., Hall, M., ... & Murad, F. (2011). Obesity as a risk factor for sedation-related complications during propofol-mediated sedation for advanced endoscopic procedures. Gastrointestinal endoscopy, 74(6), 1238-1247. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/4269 |
| publishDate | 2011 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Obesity as a risk factor for sedation-related complications during propofol-mediated sedation for advanced endoscopic proceduresAzar, RiadWani, SachinHovis, Christine E.Hovis, Robert M.Cote, Gregory A.Hall, MatthewWaldbaum, LawrenceBackground There are limited data on the safety of anesthesia-assisted endoscopy by using propofol-mediated sedation in obese individuals undergoing advanced endoscopic procedures (AEPs). Objective To study the association between obesity (as measured by body mass index [BMI]) and the frequency of sedation-related complications (SRCs) in patients undergoing AEPs. Design Prospective cohort study. Setting Tertiary referral center. Patients A total of 1016 consecutive patients undergoing AEPs (BMI <30, 730 [72%]; 30-35, 159 [16%]; >35, 127 [12%]). Intervention Monitored anesthesia sedation with propofol alone or in combination with benzodiazepines and/or opioids. Main Outcome Measurements SRCs, airway maneuvers (AMs), hypoxemia, hypotension requiring vasopressors, and early procedure termination were compared across 3 groups. Results There were 203 AMs in 13.9% of patients, hypoxemia in 7.3%, need for vasopressors in 0.8%, and premature termination in 0.6% of patients. Increasing BMI was associated with an increased frequency of AMs (BMI <30, 10.5%; 30-35, 18.9%; >35–26.8%; P < .001) and hypoxemia (BMI <30, 5.3%; 30-35, 9.4%; >35, 13.4%; P = .001); there was no difference in the frequency of need for vasopressors (P = .254) and premature termination of procedures (P = .401). On multivariable analysis, BMI (odds ratio [OR] 2.0; 95% CI, 1.3-3.1), age (OR 1.1; 95% CI, 1.0-1.1), and American Society of Anesthesiologists class 3 or higher (OR 2.4; 95% CI, 1.1-5.0) were independent predictors of SRCs. In obese individuals (n = 286), there was no difference in the frequency of SRCs in patients receiving propofol alone or in combination (P = .48). Limitations Single tertiary center study. Conclusions Although obesity was associated with an increased frequency of SRCs, propofol sedation can be used safely in obese patients undergoing AEPs when administered by trained professionals.PublishedN/A2016-09-09T13:33:56Z2016-09-09T13:33:56Z20112016-09-09Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0016-5107http://hdl.handle.net/10725/4269http://dx.doi.org/10.1016/j.gie.2011.09.006Wani, S., Azar, R., Hovis, C. E., Hovis, R. M., Cote, G. A., Hall, M., ... & Murad, F. (2011). Obesity as a risk factor for sedation-related complications during propofol-mediated sedation for advanced endoscopic procedures. Gastrointestinal endoscopy, 74(6), 1238-1247.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttp://www.sciencedirect.com/science/article/pii/S0016510711021766enGastrointestinal Endoscopyinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/42692021-03-19T10:00:50Z |
| spellingShingle | Obesity as a risk factor for sedation-related complications during propofol-mediated sedation for advanced endoscopic procedures Azar, Riad |
| status_str | publishedVersion |
| title | Obesity as a risk factor for sedation-related complications during propofol-mediated sedation for advanced endoscopic procedures |
| title_full | Obesity as a risk factor for sedation-related complications during propofol-mediated sedation for advanced endoscopic procedures |
| title_fullStr | Obesity as a risk factor for sedation-related complications during propofol-mediated sedation for advanced endoscopic procedures |
| title_full_unstemmed | Obesity as a risk factor for sedation-related complications during propofol-mediated sedation for advanced endoscopic procedures |
| title_short | Obesity as a risk factor for sedation-related complications during propofol-mediated sedation for advanced endoscopic procedures |
| title_sort | Obesity as a risk factor for sedation-related complications during propofol-mediated sedation for advanced endoscopic procedures |
| url | http://hdl.handle.net/10725/4269 http://dx.doi.org/10.1016/j.gie.2011.09.006 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.sciencedirect.com/science/article/pii/S0016510711021766 |