Early and Late Complications After Radiofrequency Ablation of Malignant Liver Tumors in 608 Patients
Background: Radiofrequency ablation (RFA) has become a common treatment of patients with unresectable primary and secondary hepatic malignancies. We performed this prospective analysis to determine early (within 30 days) and late (more than 30 days after) complication rates associated with hepatic t...
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| مؤلفون آخرون: | , , , , , , , , , , , , , , , , |
| التنسيق: | article |
| منشور في: |
2004
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/2523 http://dx.doi.org/10.1097/01.sla.0000118373.31781.f2 http://link.springer.com/article/10.1007%2FBF02524164?LI=true |
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إضافة وسم
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| _version_ | 1864513458575245312 |
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| author | Curley, Steven |
| author2 | Marra, Paolo Beaty, Karen Vauthey, Nicolas Abdalla, Eddie Scaife, Courtney Raut, Chan Wolff, Robert Choi, Haesun Loyer, Evelyne Vallone, Paolo Fiore, Francesco Scordino, Fabrizio Di Rosa, Vincenzo Orlando, Raffaele Pignata, Sandro Daniele, Bruno Izzo, Francesco |
| author2_role | author author author author author author author author author author author author author author author author author |
| author_facet | Curley, Steven Marra, Paolo Beaty, Karen Vauthey, Nicolas Abdalla, Eddie Scaife, Courtney Raut, Chan Wolff, Robert Choi, Haesun Loyer, Evelyne Vallone, Paolo Fiore, Francesco Scordino, Fabrizio Di Rosa, Vincenzo Orlando, Raffaele Pignata, Sandro Daniele, Bruno Izzo, Francesco |
| author_role | author |
| dc.creator.none.fl_str_mv | Curley, Steven Marra, Paolo Beaty, Karen Vauthey, Nicolas Abdalla, Eddie Scaife, Courtney Raut, Chan Wolff, Robert Choi, Haesun Loyer, Evelyne Vallone, Paolo Fiore, Francesco Scordino, Fabrizio Di Rosa, Vincenzo Orlando, Raffaele Pignata, Sandro Daniele, Bruno Izzo, Francesco |
| dc.date.none.fl_str_mv | 2004 2015-11-10T15:20:40Z 2015-11-10T15:20:40Z 2015-11-10 |
| dc.identifier.none.fl_str_mv | 0003-4932 http://hdl.handle.net/10725/2523 http://dx.doi.org/10.1097/01.sla.0000118373.31781.f2 Curley, S. A., Marra, P., Beaty, K., Ellis, L. M., Vauthey, J. N., Abdalla, E. K., ... & Izzo, F. (2004). Early and late complications after radiofrequency ablation of malignant liver tumors in 608 patients. Annals of surgery, 239(4), 450. http://link.springer.com/article/10.1007%2FBF02524164?LI=true |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Annals of surgery |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Early and Late Complications After Radiofrequency Ablation of Malignant Liver Tumors in 608 Patients |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Background: Radiofrequency ablation (RFA) has become a common treatment of patients with unresectable primary and secondary hepatic malignancies. We performed this prospective analysis to determine early (within 30 days) and late (more than 30 days after) complication rates associated with hepatic tumor RFA. Methods: All patients treated between January 1, 1996 and June 30, 2002 with RFA for hepatic malignancies were entered into a prospective database. Patients were evaluated during RFA treatment, throughout the immediate post RFA course, and then every 3 months after RFA to assess for the development of treatment-related complications. Results: A total of 608 patients, 345 men (56.7%) and 263 women (43.3%), with a median age of 58 years (range 18–85 years) underwent RFA of 1225 malignant liver tumors. Open intraoperative RFA was performed in 382 patients (62.8%), while percutaneous RFA was performed in 226 (37.2%). The treatment-related mortality rate was 0.5%. Early complications developed in 43 patients (7.1%). Early complications were more likely to occur in patients treated with open RFA (33 [8.6%] of 382 patients) compared with percutaneous RFA (10 [4.4%] 226 patients, P < 0.01), and in patients with cirrhosis (25 [12.9%] complications in 194 patients) compared with noncirrhotic patients (31 [7.5%] complications in 414 patients, P < 0.05). Late complications arose in 15 patients (2.4%) with no difference in incidence between open and percutaneous RFA treatment. The combined overall early and late complication rate was 9.5%. Conclusions: Hepatic tumor RFA can be performed with low mortality and morbidity rates. Though relatively rare, late complications can develop and physicians performing hepatic RFA must be cognizant of these delayed treatment-related problems. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_5d441d8bcf32d1d7d85096d70a15ec38 |
| identifier_str_mv | 0003-4932 Curley, S. A., Marra, P., Beaty, K., Ellis, L. M., Vauthey, J. N., Abdalla, E. K., ... & Izzo, F. (2004). Early and late complications after radiofrequency ablation of malignant liver tumors in 608 patients. Annals of surgery, 239(4), 450. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/2523 |
| publishDate | 2004 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Early and Late Complications After Radiofrequency Ablation of Malignant Liver Tumors in 608 PatientsCurley, StevenMarra, PaoloBeaty, KarenVauthey, NicolasAbdalla, EddieScaife, CourtneyRaut, ChanWolff, RobertChoi, HaesunLoyer, EvelyneVallone, PaoloFiore, FrancescoScordino, FabrizioDi Rosa, VincenzoOrlando, RaffaelePignata, SandroDaniele, BrunoIzzo, FrancescoBackground: Radiofrequency ablation (RFA) has become a common treatment of patients with unresectable primary and secondary hepatic malignancies. We performed this prospective analysis to determine early (within 30 days) and late (more than 30 days after) complication rates associated with hepatic tumor RFA. Methods: All patients treated between January 1, 1996 and June 30, 2002 with RFA for hepatic malignancies were entered into a prospective database. Patients were evaluated during RFA treatment, throughout the immediate post RFA course, and then every 3 months after RFA to assess for the development of treatment-related complications. Results: A total of 608 patients, 345 men (56.7%) and 263 women (43.3%), with a median age of 58 years (range 18–85 years) underwent RFA of 1225 malignant liver tumors. Open intraoperative RFA was performed in 382 patients (62.8%), while percutaneous RFA was performed in 226 (37.2%). The treatment-related mortality rate was 0.5%. Early complications developed in 43 patients (7.1%). Early complications were more likely to occur in patients treated with open RFA (33 [8.6%] of 382 patients) compared with percutaneous RFA (10 [4.4%] 226 patients, P < 0.01), and in patients with cirrhosis (25 [12.9%] complications in 194 patients) compared with noncirrhotic patients (31 [7.5%] complications in 414 patients, P < 0.05). Late complications arose in 15 patients (2.4%) with no difference in incidence between open and percutaneous RFA treatment. The combined overall early and late complication rate was 9.5%. Conclusions: Hepatic tumor RFA can be performed with low mortality and morbidity rates. Though relatively rare, late complications can develop and physicians performing hepatic RFA must be cognizant of these delayed treatment-related problems.PublishedN/A2015-11-10T15:20:40Z2015-11-10T15:20:40Z20042015-11-10Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0003-4932http://hdl.handle.net/10725/2523http://dx.doi.org/10.1097/01.sla.0000118373.31781.f2Curley, S. A., Marra, P., Beaty, K., Ellis, L. M., Vauthey, J. N., Abdalla, E. K., ... & Izzo, F. (2004). Early and late complications after radiofrequency ablation of malignant liver tumors in 608 patients. Annals of surgery, 239(4), 450.http://link.springer.com/article/10.1007%2FBF02524164?LI=trueenAnnals of surgeryinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/25232019-02-26T08:23:58Z |
| spellingShingle | Early and Late Complications After Radiofrequency Ablation of Malignant Liver Tumors in 608 Patients Curley, Steven |
| status_str | publishedVersion |
| title | Early and Late Complications After Radiofrequency Ablation of Malignant Liver Tumors in 608 Patients |
| title_full | Early and Late Complications After Radiofrequency Ablation of Malignant Liver Tumors in 608 Patients |
| title_fullStr | Early and Late Complications After Radiofrequency Ablation of Malignant Liver Tumors in 608 Patients |
| title_full_unstemmed | Early and Late Complications After Radiofrequency Ablation of Malignant Liver Tumors in 608 Patients |
| title_short | Early and Late Complications After Radiofrequency Ablation of Malignant Liver Tumors in 608 Patients |
| title_sort | Early and Late Complications After Radiofrequency Ablation of Malignant Liver Tumors in 608 Patients |
| url | http://hdl.handle.net/10725/2523 http://dx.doi.org/10.1097/01.sla.0000118373.31781.f2 http://link.springer.com/article/10.1007%2FBF02524164?LI=true |