P-glycoprotein expression and function are increased in an animal model of amyotrophic lateral sclerosis

P-glycoprotein expression and function are increased in an animal model of amyotrophic lateral sclerosis

The efflux pumps located at the blood–brain barrier (BBB) prevent drugs entering the brain. As such, efflux pumps are a major obstacle to drug brain distribution. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with little therapeutics available: riluzole is the only drug ap...

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Bibliographic Details
Main Author: Milane, Aline (author)
Other Authors: Fernandez, Christine (author), Dupuis, Luc (author), Buyse, Marion (author), Loeffler, Jean-Philippe (author), Farinotti, Robert (author), Meininger, Vincent (author), Bensimon, Gilbert (author)
Format: article
Published: 2010
Online Access:http://hdl.handle.net/10725/4497
http://dx.doi.org/10.1016/j.neulet.2010.01.078
http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php
http://www.sciencedirect.com/science/article/pii/S030439401000131X
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http://hdl.handle.net/10725/4497
http://dx.doi.org/10.1016/j.neulet.2010.01.078
http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php
http://www.sciencedirect.com/science/article/pii/S030439401000131X

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