P-glycoprotein expression and function are increased in an animal model of amyotrophic lateral sclerosis
The efflux pumps located at the blood–brain barrier (BBB) prevent drugs entering the brain. As such, efflux pumps are a major obstacle to drug brain distribution. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with little therapeutics available: riluzole is the only drug ap...
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| Format: | article |
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2010
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| Online Access: | http://hdl.handle.net/10725/4497 http://dx.doi.org/10.1016/j.neulet.2010.01.078 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.sciencedirect.com/science/article/pii/S030439401000131X |
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