Synthesis of 2,3-diarylglutaramides and their antibacterial activity
2,3-Diarylglutaramides (4) have been prepared by a one-pot reaction involving hydrolysis of the corresponding diastereomeric (R, R)-glutaronitriles (3) with conc. sulphuric acid at room temperature. Their structure has been established on the basis of their elemental analyses and IR, 1H and 13C NMR...
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| Format: | article |
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1990
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| Online Access: | http://hdl.handle.net/10725/9897 https://doi.org/10.1002/chin.199043136 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.researchgate.net/publication/294525504_Synthesis_of_23-diarylglutaramides_and_their_antibacterial_activity |
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| Summary: | 2,3-Diarylglutaramides (4) have been prepared by a one-pot reaction involving hydrolysis of the corresponding diastereomeric (R, R)-glutaronitriles (3) with conc. sulphuric acid at room temperature. Their structure has been established on the basis of their elemental analyses and IR, 1H and 13C NMR spectral data. The antibacterial activity of both 3 and 4 against P .aeruginosa, E. coli, S. aureus and E.faecalis has been determined. |
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