The effect of 595 nm pulsed dye laser on superficial and nodular basal cell carcinomas
Background and Objective Basal cell carcinomas (BCCs) have supporting vasculature that could serve as a target for 595 nm pulsed dye laser (PDL). The objective of this study was to determine the effect of repeated PDL treatments on BCCs of superficial and nodular subtypes and of varying diameters. S...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , |
| التنسيق: | article |
| منشور في: |
2009
|
| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/6550 http://dx.doi.org/10.1002/lsm.20787 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://onlinelibrary.wiley.com/doi/10.1002/lsm.20787/full |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513466177421312 |
|---|---|
| author | Tannous, Zeina S. |
| author2 | Konnikov, Nellie Shah, Sonali M. Duncan, Lyn M. |
| author2_role | author author author |
| author_facet | Tannous, Zeina S. Konnikov, Nellie Shah, Sonali M. Duncan, Lyn M. |
| author_role | author |
| dc.creator.none.fl_str_mv | Tannous, Zeina S. Konnikov, Nellie Shah, Sonali M. Duncan, Lyn M. |
| dc.date.none.fl_str_mv | 2009 2017-11-08T10:05:11Z 2017-11-08T10:05:11Z 2017-11-08 |
| dc.identifier.none.fl_str_mv | 1096-9101 http://hdl.handle.net/10725/6550 http://dx.doi.org/10.1002/lsm.20787 Shah, S. M., Konnikov, N., Duncan, L. M., & Tannous, Z. S. (2009). The effect of 595 nm pulsed dye laser on superficial and nodular basal cell carcinomas. Lasers in surgery and medicine, 41(6), 417-422. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://onlinelibrary.wiley.com/doi/10.1002/lsm.20787/full |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Lasers in Surgery and Medicine |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | The effect of 595 nm pulsed dye laser on superficial and nodular basal cell carcinomas |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Background and Objective Basal cell carcinomas (BCCs) have supporting vasculature that could serve as a target for 595 nm pulsed dye laser (PDL). The objective of this study was to determine the effect of repeated PDL treatments on BCCs of superficial and nodular subtypes and of varying diameters. Study Design/Materials and Methods Twenty biopsy-proven BCCs received four 595 nm PDL treatments at 2-week intervals. The tumor and 4 mm of peripheral skin were treated using a set of previously optimized laser parameters: one pass, 15 J/cm2 energy, 3 ms pulse length, no cooling, and 7 mm spot size with 10% overlap. The treated area was excised and evaluated histologically for residual tumor. Histologic response rates of the PDL treated BCCs were compared with that of non-PDL treated, matched control tumors. Results Nearly all BCCs <1.5 cm in diameter (n = 12) showed complete response to four PDL treatments (91.7%; n = 11/12) versus 16.7% of controls (n = 2/12, P-value = 0.0003). BCCs ≥1.5 cm in diameter (n = 8) showed a complete response rate of 25% (n = 2/8) versus 0% of controls (n = 0/8, P-value = 0.2). Mean clinical tumor diameter of the complete responders was 1.1 cm (n = 13) versus 2.2 cm (n = 7) for incomplete responders (P-value = 0.005). Tumor histologic types among the complete responders included superficial, nodular, micronodular, and keratinizing. Incompletely responding BCCs showed a significant reduction in tumor burden after PDL treatment, with residual histologic tumor burden ranging from <1% to 29% of the original clinical tumor diameter, compared to 13–68% residual tumor burden for the corresponding controls (P-value = 0.05). Conclusions PDL is an effective means of reducing tumor burden in patients with large BCCs and may be an alternative therapy in BCCs <1.5 cm in diameter. Lasers Surg. Med. 41:417–422, 2009. © 2009 Wiley-Liss, Inc. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_642ec68219fa1e69dc11217bb9963fd8 |
| identifier_str_mv | 1096-9101 Shah, S. M., Konnikov, N., Duncan, L. M., & Tannous, Z. S. (2009). The effect of 595 nm pulsed dye laser on superficial and nodular basal cell carcinomas. Lasers in surgery and medicine, 41(6), 417-422. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/6550 |
| publishDate | 2009 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | The effect of 595 nm pulsed dye laser on superficial and nodular basal cell carcinomasTannous, Zeina S.Konnikov, NellieShah, Sonali M.Duncan, Lyn M.Background and Objective Basal cell carcinomas (BCCs) have supporting vasculature that could serve as a target for 595 nm pulsed dye laser (PDL). The objective of this study was to determine the effect of repeated PDL treatments on BCCs of superficial and nodular subtypes and of varying diameters. Study Design/Materials and Methods Twenty biopsy-proven BCCs received four 595 nm PDL treatments at 2-week intervals. The tumor and 4 mm of peripheral skin were treated using a set of previously optimized laser parameters: one pass, 15 J/cm2 energy, 3 ms pulse length, no cooling, and 7 mm spot size with 10% overlap. The treated area was excised and evaluated histologically for residual tumor. Histologic response rates of the PDL treated BCCs were compared with that of non-PDL treated, matched control tumors. Results Nearly all BCCs <1.5 cm in diameter (n = 12) showed complete response to four PDL treatments (91.7%; n = 11/12) versus 16.7% of controls (n = 2/12, P-value = 0.0003). BCCs ≥1.5 cm in diameter (n = 8) showed a complete response rate of 25% (n = 2/8) versus 0% of controls (n = 0/8, P-value = 0.2). Mean clinical tumor diameter of the complete responders was 1.1 cm (n = 13) versus 2.2 cm (n = 7) for incomplete responders (P-value = 0.005). Tumor histologic types among the complete responders included superficial, nodular, micronodular, and keratinizing. Incompletely responding BCCs showed a significant reduction in tumor burden after PDL treatment, with residual histologic tumor burden ranging from <1% to 29% of the original clinical tumor diameter, compared to 13–68% residual tumor burden for the corresponding controls (P-value = 0.05). Conclusions PDL is an effective means of reducing tumor burden in patients with large BCCs and may be an alternative therapy in BCCs <1.5 cm in diameter. Lasers Surg. Med. 41:417–422, 2009. © 2009 Wiley-Liss, Inc.PublishedN/A2017-11-08T10:05:11Z2017-11-08T10:05:11Z20092017-11-08Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1096-9101http://hdl.handle.net/10725/6550http://dx.doi.org/10.1002/lsm.20787Shah, S. M., Konnikov, N., Duncan, L. M., & Tannous, Z. S. (2009). The effect of 595 nm pulsed dye laser on superficial and nodular basal cell carcinomas. Lasers in surgery and medicine, 41(6), 417-422.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttp://onlinelibrary.wiley.com/doi/10.1002/lsm.20787/fullenLasers in Surgery and Medicineinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/65502021-03-19T10:03:27Z |
| spellingShingle | The effect of 595 nm pulsed dye laser on superficial and nodular basal cell carcinomas Tannous, Zeina S. |
| status_str | publishedVersion |
| title | The effect of 595 nm pulsed dye laser on superficial and nodular basal cell carcinomas |
| title_full | The effect of 595 nm pulsed dye laser on superficial and nodular basal cell carcinomas |
| title_fullStr | The effect of 595 nm pulsed dye laser on superficial and nodular basal cell carcinomas |
| title_full_unstemmed | The effect of 595 nm pulsed dye laser on superficial and nodular basal cell carcinomas |
| title_short | The effect of 595 nm pulsed dye laser on superficial and nodular basal cell carcinomas |
| title_sort | The effect of 595 nm pulsed dye laser on superficial and nodular basal cell carcinomas |
| url | http://hdl.handle.net/10725/6550 http://dx.doi.org/10.1002/lsm.20787 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://onlinelibrary.wiley.com/doi/10.1002/lsm.20787/full |