Improved Survival after Resection of Liver and Lung Colorectal Metastases Compared with Liver-Only Metastases
Background Lung metastases are considered a poor prognostic factor in patients with resectable colorectal liver metastases. Study Design We reviewed records of 1,260 consecutive patients with liver-only or liver-plus-lung (L+L) metastases from colorectal cancer who underwent resection with curative...
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| مؤلفون آخرون: | , , , , , , , |
| التنسيق: | article |
| منشور في: |
2011
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/2631 http://dx.doi.org/10.1016/j.jamcollsurg.2011.05.001 http://www.sciencedirect.com/science/article/pii/S1072751511003383 |
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| _version_ | 1864513458998870016 |
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| author | Brouquet, Antoine |
| author2 | Vauthey, Jean-Nicolas Contreras, Carlo Walsh, Garett Vaporciyan, Ara Swisher, Stephen Curley, Steven Mehran, Reza Abdalla, Eddie |
| author2_role | author author author author author author author author |
| author_facet | Brouquet, Antoine Vauthey, Jean-Nicolas Contreras, Carlo Walsh, Garett Vaporciyan, Ara Swisher, Stephen Curley, Steven Mehran, Reza Abdalla, Eddie |
| author_role | author |
| dc.creator.none.fl_str_mv | Brouquet, Antoine Vauthey, Jean-Nicolas Contreras, Carlo Walsh, Garett Vaporciyan, Ara Swisher, Stephen Curley, Steven Mehran, Reza Abdalla, Eddie |
| dc.date.none.fl_str_mv | 2011 2015-11-19T12:08:29Z 2015-11-19T12:08:29Z 2017-04-11 |
| dc.identifier.none.fl_str_mv | 1072-7515 http://hdl.handle.net/10725/2631 http://dx.doi.org/10.1016/j.jamcollsurg.2011.05.001 Brouquet, A., Vauthey, J. N., Contreras, C. M., Walsh, G. L., Vaporciyan, A. A., Swisher, S. G., ... & Abdalla, E. K. (2011). Improved survival after resection of liver and lung colorectal metastases compared with liver-only metastases: a study of 112 patients with limited lung metastatic disease. Journal of the American College of Surgeons, 213(1), 62-69. http://www.sciencedirect.com/science/article/pii/S1072751511003383 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Journal of the American College of Surgeons |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Improved Survival after Resection of Liver and Lung Colorectal Metastases Compared with Liver-Only Metastases A Study of 112 Patients with Limited Lung Metastatic Disease |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Background Lung metastases are considered a poor prognostic factor in patients with resectable colorectal liver metastases. Study Design We reviewed records of 1,260 consecutive patients with liver-only or liver-plus-lung (L+L) metastases from colorectal cancer who underwent resection with curative intent (1995 to 2009). Survival and prognostic factors were analyzed. Results There were 112 patients who underwent resection of L+L (mean 2 liver, 2 lung metastases). Mean tumor sizes were 3 cm and 1 cm, respectively. Thirty-four (31%) had bilateral lung metastases. Ten (9%) had synchronous L+L metastases, 60 (54%) had diagnosis of lung metastases within 1 year of liver resection. Most (108 of 112, 96%) had resection of liver before or at the same time as lung. Preoperative chemotherapy was used in 77 (69%) before liver resection and 56 (50%) before lung resection. Among L+L patients, no postoperative deaths occurred; postoperative morbidity rates were 26% after liver resection and 4% after lung resection. After a median of 49 months follow-up, L+L patients (n = 112) had better survival than liver only (n = 1,148) (5-year overall survival, L+L, 50% vs liver only, 40%; p = 0.01). CEA level > 5 ng/dL (hazard ratio [HR] 2.1, 95% CI 1.1 to 4.4, p = 0.04) and rectal primary (HR 2.9, 95% CI 1.4 to 6, p = 0.004) were associated with worse survival in L+L patients. Conclusions The survival rate for patients who undergo resection of L+L metastases from colorectal cancer is greater than the survival rate of the general population of patients who undergo resection of liver metastases only. The presence of resectable lung metastases is neither a poor prognostic factor nor a contraindication to resection of liver metastases. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_66bedf78fed3db3fcc77166801c06f03 |
| identifier_str_mv | 1072-7515 Brouquet, A., Vauthey, J. N., Contreras, C. M., Walsh, G. L., Vaporciyan, A. A., Swisher, S. G., ... & Abdalla, E. K. (2011). Improved survival after resection of liver and lung colorectal metastases compared with liver-only metastases: a study of 112 patients with limited lung metastatic disease. Journal of the American College of Surgeons, 213(1), 62-69. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/2631 |
| publishDate | 2011 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Improved Survival after Resection of Liver and Lung Colorectal Metastases Compared with Liver-Only MetastasesA Study of 112 Patients with Limited Lung Metastatic DiseaseBrouquet, AntoineVauthey, Jean-NicolasContreras, CarloWalsh, GarettVaporciyan, AraSwisher, StephenCurley, StevenMehran, RezaAbdalla, EddieBackground Lung metastases are considered a poor prognostic factor in patients with resectable colorectal liver metastases. Study Design We reviewed records of 1,260 consecutive patients with liver-only or liver-plus-lung (L+L) metastases from colorectal cancer who underwent resection with curative intent (1995 to 2009). Survival and prognostic factors were analyzed. Results There were 112 patients who underwent resection of L+L (mean 2 liver, 2 lung metastases). Mean tumor sizes were 3 cm and 1 cm, respectively. Thirty-four (31%) had bilateral lung metastases. Ten (9%) had synchronous L+L metastases, 60 (54%) had diagnosis of lung metastases within 1 year of liver resection. Most (108 of 112, 96%) had resection of liver before or at the same time as lung. Preoperative chemotherapy was used in 77 (69%) before liver resection and 56 (50%) before lung resection. Among L+L patients, no postoperative deaths occurred; postoperative morbidity rates were 26% after liver resection and 4% after lung resection. After a median of 49 months follow-up, L+L patients (n = 112) had better survival than liver only (n = 1,148) (5-year overall survival, L+L, 50% vs liver only, 40%; p = 0.01). CEA level > 5 ng/dL (hazard ratio [HR] 2.1, 95% CI 1.1 to 4.4, p = 0.04) and rectal primary (HR 2.9, 95% CI 1.4 to 6, p = 0.004) were associated with worse survival in L+L patients. Conclusions The survival rate for patients who undergo resection of L+L metastases from colorectal cancer is greater than the survival rate of the general population of patients who undergo resection of liver metastases only. The presence of resectable lung metastases is neither a poor prognostic factor nor a contraindication to resection of liver metastases.PublishedN/A2015-11-19T12:08:29Z2015-11-19T12:08:29Z20112017-04-11Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1072-7515http://hdl.handle.net/10725/2631http://dx.doi.org/10.1016/j.jamcollsurg.2011.05.001Brouquet, A., Vauthey, J. N., Contreras, C. M., Walsh, G. L., Vaporciyan, A. A., Swisher, S. G., ... & Abdalla, E. K. (2011). Improved survival after resection of liver and lung colorectal metastases compared with liver-only metastases: a study of 112 patients with limited lung metastatic disease. Journal of the American College of Surgeons, 213(1), 62-69.http://www.sciencedirect.com/science/article/pii/S1072751511003383enJournal of the American College of Surgeonsinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/26312021-03-19T09:59:49Z |
| spellingShingle | Improved Survival after Resection of Liver and Lung Colorectal Metastases Compared with Liver-Only Metastases Brouquet, Antoine |
| status_str | publishedVersion |
| title | Improved Survival after Resection of Liver and Lung Colorectal Metastases Compared with Liver-Only Metastases |
| title_full | Improved Survival after Resection of Liver and Lung Colorectal Metastases Compared with Liver-Only Metastases |
| title_fullStr | Improved Survival after Resection of Liver and Lung Colorectal Metastases Compared with Liver-Only Metastases |
| title_full_unstemmed | Improved Survival after Resection of Liver and Lung Colorectal Metastases Compared with Liver-Only Metastases |
| title_short | Improved Survival after Resection of Liver and Lung Colorectal Metastases Compared with Liver-Only Metastases |
| title_sort | Improved Survival after Resection of Liver and Lung Colorectal Metastases Compared with Liver-Only Metastases |
| url | http://hdl.handle.net/10725/2631 http://dx.doi.org/10.1016/j.jamcollsurg.2011.05.001 http://www.sciencedirect.com/science/article/pii/S1072751511003383 |