Modeling circadian clock–cell cycle interaction effects on cell population growth rates
The circadian clock and the cell cycle are two tightly coupled oscillators. Recent analytical studies have shown counter-intuitive effects of circadian gating of the cell cycle on growth rates of proliferating cells which cannot be explained by a molecular model or a population model alone. In this...
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2014
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| Online Access: | http://hdl.handle.net/10725/4885 http://dx.doi.org/10.1016/j.jtbi.2014.08.008 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.sciencedirect.com/science/article/pii/S0022519314004561 |
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| _version_ | 1864513464888721408 |
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| author | El Khatib, N. |
| author2 | El Cheikh, R. Bernard, S. |
| author2_role | author author |
| author_facet | El Khatib, N. El Cheikh, R. Bernard, S. |
| author_role | author |
| dc.creator.none.fl_str_mv | El Khatib, N. El Cheikh, R. Bernard, S. |
| dc.date.none.fl_str_mv | 2014 2016-12-06T10:58:51Z 2016-12-06T10:58:51Z 2016-12-06 |
| dc.identifier.none.fl_str_mv | 0022-5193 http://hdl.handle.net/10725/4885 http://dx.doi.org/10.1016/j.jtbi.2014.08.008 El Cheikh, R., Bernard, S., & El Khatib, N. (2014). Modeling circadian clock–cell cycle interaction effects on cell population growth rates. Journal of theoretical biology, 363, 318-331. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.sciencedirect.com/science/article/pii/S0022519314004561 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Journal of Theoretical Biology |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Modeling circadian clock–cell cycle interaction effects on cell population growth rates |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | The circadian clock and the cell cycle are two tightly coupled oscillators. Recent analytical studies have shown counter-intuitive effects of circadian gating of the cell cycle on growth rates of proliferating cells which cannot be explained by a molecular model or a population model alone. In this work, we present a combined molecular-population model that studies how coupling the circadian clock to the cell cycle, through the protein WEE1, affects a proliferating cell population. We show that the cell cycle can entrain to the circadian clock with different rational period ratios and characterize multiple domains of entrainment. We show that coupling increases the growth rate for autonomous periods of the cell cycle around 24 h and above 48 h. We study the effect of mutation of circadian genes on the growth rate of cells and show that disruption of the circadian clock can lead to abnormal proliferation. Particularly, we show that Cry 1, Cry 2 mutations decrease the growth rate of cells, Per 2 mutation enhances it and Bmal 1 knockout increases it for autonomous periods of the cell cycle less than 21 h and decreases it elsewhere. Combining a molecular model to a population model offers new insight on the influence of the circadian clock on the growth of a cell population. This can help chronotherapy which takes benefits of physiological rhythms to improve anti-cancer efficacy and tolerance to drugs by administering treatments at a specific time of the day. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_6ac46d00166496c4e8a3c48eadc54545 |
| identifier_str_mv | 0022-5193 El Cheikh, R., Bernard, S., & El Khatib, N. (2014). Modeling circadian clock–cell cycle interaction effects on cell population growth rates. Journal of theoretical biology, 363, 318-331. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/4885 |
| publishDate | 2014 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Modeling circadian clock–cell cycle interaction effects on cell population growth ratesEl Khatib, N.El Cheikh, R.Bernard, S.The circadian clock and the cell cycle are two tightly coupled oscillators. Recent analytical studies have shown counter-intuitive effects of circadian gating of the cell cycle on growth rates of proliferating cells which cannot be explained by a molecular model or a population model alone. In this work, we present a combined molecular-population model that studies how coupling the circadian clock to the cell cycle, through the protein WEE1, affects a proliferating cell population. We show that the cell cycle can entrain to the circadian clock with different rational period ratios and characterize multiple domains of entrainment. We show that coupling increases the growth rate for autonomous periods of the cell cycle around 24 h and above 48 h. We study the effect of mutation of circadian genes on the growth rate of cells and show that disruption of the circadian clock can lead to abnormal proliferation. Particularly, we show that Cry 1, Cry 2 mutations decrease the growth rate of cells, Per 2 mutation enhances it and Bmal 1 knockout increases it for autonomous periods of the cell cycle less than 21 h and decreases it elsewhere. Combining a molecular model to a population model offers new insight on the influence of the circadian clock on the growth of a cell population. This can help chronotherapy which takes benefits of physiological rhythms to improve anti-cancer efficacy and tolerance to drugs by administering treatments at a specific time of the day.PublishedN/A2016-12-06T10:58:51Z2016-12-06T10:58:51Z20142016-12-06Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0022-5193http://hdl.handle.net/10725/4885http://dx.doi.org/10.1016/j.jtbi.2014.08.008El Cheikh, R., Bernard, S., & El Khatib, N. (2014). Modeling circadian clock–cell cycle interaction effects on cell population growth rates. Journal of theoretical biology, 363, 318-331.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttp://www.sciencedirect.com/science/article/pii/S0022519314004561enJournal of Theoretical Biologyinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/48852021-03-19T10:03:22Z |
| spellingShingle | Modeling circadian clock–cell cycle interaction effects on cell population growth rates El Khatib, N. |
| status_str | publishedVersion |
| title | Modeling circadian clock–cell cycle interaction effects on cell population growth rates |
| title_full | Modeling circadian clock–cell cycle interaction effects on cell population growth rates |
| title_fullStr | Modeling circadian clock–cell cycle interaction effects on cell population growth rates |
| title_full_unstemmed | Modeling circadian clock–cell cycle interaction effects on cell population growth rates |
| title_short | Modeling circadian clock–cell cycle interaction effects on cell population growth rates |
| title_sort | Modeling circadian clock–cell cycle interaction effects on cell population growth rates |
| url | http://hdl.handle.net/10725/4885 http://dx.doi.org/10.1016/j.jtbi.2014.08.008 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.sciencedirect.com/science/article/pii/S0022519314004561 |