Scatter search for protein structure prediction. (c2008)
Includes bibliographical references (leaves 50-52).
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| التنسيق: | masterThesis |
| منشور في: |
2008
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/878 https://doi.org/10.26756/th.2008.34 |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513455298445312 |
|---|---|
| author | Kehyayan, Christine Houry |
| author_facet | Kehyayan, Christine Houry |
| author_role | author |
| dc.creator.none.fl_str_mv | Kehyayan, Christine Houry |
| dc.date.none.fl_str_mv | 2008 2008-02-04 2011-10-25T06:24:38Z 2011-10-25T06:24:38Z 2011-10-25 |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10725/878 https://doi.org/10.26756/th.2008.34 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Lebanese American University |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Proteins -- Structure -- Mathematical models Amino acid sequence Computer algorithms -- Statistical applications |
| dc.title.none.fl_str_mv | Scatter search for protein structure prediction. (c2008) |
| dc.type.none.fl_str_mv | Thesis info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/masterThesis |
| description | Includes bibliographical references (leaves 50-52). |
| eu_rights_str_mv | openAccess |
| format | masterThesis |
| id | LAURepo_6bdd42e94375121fa34c2daaae933344 |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/878 |
| publishDate | 2008 |
| publisher.none.fl_str_mv | Lebanese American University |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Scatter search for protein structure prediction. (c2008)Kehyayan, Christine HouryProteins -- Structure -- Mathematical modelsAmino acid sequenceComputer algorithms -- Statistical applicationsIncludes bibliographical references (leaves 50-52).Proteins are organic compounds made up of chains of amino acids. These amino acids are formed from atoms and the chain fold into complex 3-dimensional structures based on their chemical and physical properties. A protein is characterized by its 3D structure, which defines its biological function. The protein structure prediction problem has real world significance where several diseases such as Alzheimer, cystic fibrosis, mad cow disease, and many cancers are associated with the wrong folding of proteins. Computational methods for predicting protein structures have recently gained popularity. In this thesis, we present a scatter search algorithm for predicting 3D structures of proteins. Given the protein's sequence of amino acids and data collected from known protein structures, our algorithm produces a 3D structure that aims to minimize the energy function associated with protein folding. Scatter search is an evolutionary approach that is based on a population of solution candidates. These candidates undergo evolutionary operations that combine search intensification and diversification over a number of iterations. We evaluate our algorithm on three proteins taken from a protein data bank. The results show that our algorithm is able to produce 3D structures with good sub-optimal energy values. Also, the root mean square deviations of these structures from the reference proteins are promising within limits imposed by the assumptions used.1 bound copy: ix, 52 leaves; ill.; 30 cm. available at RNL.Lebanese American University2011-10-25T06:24:38Z2011-10-25T06:24:38Z20082011-10-252008-02-04Thesisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesishttp://hdl.handle.net/10725/878https://doi.org/10.26756/th.2008.34eninfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/8782020-05-18T14:53:47Z |
| spellingShingle | Scatter search for protein structure prediction. (c2008) Kehyayan, Christine Houry Proteins -- Structure -- Mathematical models Amino acid sequence Computer algorithms -- Statistical applications |
| status_str | publishedVersion |
| title | Scatter search for protein structure prediction. (c2008) |
| title_full | Scatter search for protein structure prediction. (c2008) |
| title_fullStr | Scatter search for protein structure prediction. (c2008) |
| title_full_unstemmed | Scatter search for protein structure prediction. (c2008) |
| title_short | Scatter search for protein structure prediction. (c2008) |
| title_sort | Scatter search for protein structure prediction. (c2008) |
| topic | Proteins -- Structure -- Mathematical models Amino acid sequence Computer algorithms -- Statistical applications |
| url | http://hdl.handle.net/10725/878 https://doi.org/10.26756/th.2008.34 |