Autologous adipose-derived mesenchymal stem cells embedded in platelet-rich fibrin in diabetic foot ulcers
Context and Aim: Mesenchymal stem cells (MSCs) and platelet-rich fibrin (PRF) have emerged as ideal candidates for advanced therapies of various therapeutically-challenging diseases; however, their regenerative potential in diabetic foot ulcers (DFU) has not been well determined. In this study, we r...
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| Other Authors: | , , , , , , , , |
| Format: | article |
| Published: |
2021
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| Online Access: | http://hdl.handle.net/10725/14205 https://doi.org/10.4236/ojrm.2021.102002 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.scirp.org/journal/paperinformation.aspx?paperid=110795 |
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| Summary: | Context and Aim: Mesenchymal stem cells (MSCs) and platelet-rich fibrin (PRF) have emerged as ideal candidates for advanced therapies of various therapeutically-challenging diseases; however, their regenerative potential in diabetic foot ulcers (DFU) has not been well determined. In this study, we reviewed our clinical experience in mitigating chronic ulcer complications of diabetic foot through a conventional treatment of autologous adipose-derived MSCs embedded in PRF with pure PRF injections. Materials and Methods: The present study was carried out in 10 patients with an open DFU wound selected over a period of 1 year starting from April 2019. Patients were either injected with PRF alone (Group A) or injected with MSCs derived from adipose tissue (ADMSC) embedded in (PRF (Group B). Results: Patients in Group B had a better healing index when compared to Group A. Conclusion: Use of ADMSC embedded in PRF showed promising results to treat DFU. |
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