Autologous adipose-derived mesenchymal stem cells embedded in platelet-rich fibrin in diabetic foot ulcers
Context and Aim: Mesenchymal stem cells (MSCs) and platelet-rich fibrin (PRF) have emerged as ideal candidates for advanced therapies of various therapeutically-challenging diseases; however, their regenerative potential in diabetic foot ulcers (DFU) has not been well determined. In this study, we r...
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2021
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| Online Access: | http://hdl.handle.net/10725/14205 https://doi.org/10.4236/ojrm.2021.102002 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.scirp.org/journal/paperinformation.aspx?paperid=110795 |
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| _version_ | 1864513469182640128 |
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| author | Khalil, Charbel |
| author2 | Chaker, Diana Salameh, Rawad Germanos, Yvonne-Elise El Kayem, Elie Nader, Fady Habbouche, Jessica Chemaly, Rodrigue Azar, Albert Ibrahim, Ahmad |
| author2_role | author author author author author author author author author |
| author_facet | Khalil, Charbel Chaker, Diana Salameh, Rawad Germanos, Yvonne-Elise El Kayem, Elie Nader, Fady Habbouche, Jessica Chemaly, Rodrigue Azar, Albert Ibrahim, Ahmad |
| author_role | author |
| dc.creator.none.fl_str_mv | Khalil, Charbel Chaker, Diana Salameh, Rawad Germanos, Yvonne-Elise El Kayem, Elie Nader, Fady Habbouche, Jessica Chemaly, Rodrigue Azar, Albert Ibrahim, Ahmad |
| dc.date.none.fl_str_mv | 2021 2022-11-02T11:17:34Z 2022-11-02T11:17:34Z 2022-11-02 |
| dc.identifier.none.fl_str_mv | 2169-2513 http://hdl.handle.net/10725/14205 https://doi.org/10.4236/ojrm.2021.102002 Khalil, C., Chaker, D., Salameh, R., Germanos, Y. E., El Kayem, E., Nader, F., ... & Ibrahim, A. (2021). Autologous Adipose-Derived Mesenchymal Stem Cells Embedded in Platelet-Rich Fibrin in Diabetic Foot Ulcers. Open Journal of Regenerative Medicine, 10(2), 19-30. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.scirp.org/journal/paperinformation.aspx?paperid=110795 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Open Journal of Regenerative Medicine |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Autologous adipose-derived mesenchymal stem cells embedded in platelet-rich fibrin in diabetic foot ulcers |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Context and Aim: Mesenchymal stem cells (MSCs) and platelet-rich fibrin (PRF) have emerged as ideal candidates for advanced therapies of various therapeutically-challenging diseases; however, their regenerative potential in diabetic foot ulcers (DFU) has not been well determined. In this study, we reviewed our clinical experience in mitigating chronic ulcer complications of diabetic foot through a conventional treatment of autologous adipose-derived MSCs embedded in PRF with pure PRF injections. Materials and Methods: The present study was carried out in 10 patients with an open DFU wound selected over a period of 1 year starting from April 2019. Patients were either injected with PRF alone (Group A) or injected with MSCs derived from adipose tissue (ADMSC) embedded in (PRF (Group B). Results: Patients in Group B had a better healing index when compared to Group A. Conclusion: Use of ADMSC embedded in PRF showed promising results to treat DFU. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_757347072eb4e549e9ac498400bbd009 |
| identifier_str_mv | 2169-2513 Khalil, C., Chaker, D., Salameh, R., Germanos, Y. E., El Kayem, E., Nader, F., ... & Ibrahim, A. (2021). Autologous Adipose-Derived Mesenchymal Stem Cells Embedded in Platelet-Rich Fibrin in Diabetic Foot Ulcers. Open Journal of Regenerative Medicine, 10(2), 19-30. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/14205 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Autologous adipose-derived mesenchymal stem cells embedded in platelet-rich fibrin in diabetic foot ulcersKhalil, CharbelChaker, DianaSalameh, RawadGermanos, Yvonne-EliseEl Kayem, ElieNader, FadyHabbouche, JessicaChemaly, RodrigueAzar, AlbertIbrahim, AhmadContext and Aim: Mesenchymal stem cells (MSCs) and platelet-rich fibrin (PRF) have emerged as ideal candidates for advanced therapies of various therapeutically-challenging diseases; however, their regenerative potential in diabetic foot ulcers (DFU) has not been well determined. In this study, we reviewed our clinical experience in mitigating chronic ulcer complications of diabetic foot through a conventional treatment of autologous adipose-derived MSCs embedded in PRF with pure PRF injections. Materials and Methods: The present study was carried out in 10 patients with an open DFU wound selected over a period of 1 year starting from April 2019. Patients were either injected with PRF alone (Group A) or injected with MSCs derived from adipose tissue (ADMSC) embedded in (PRF (Group B). Results: Patients in Group B had a better healing index when compared to Group A. Conclusion: Use of ADMSC embedded in PRF showed promising results to treat DFU.Published2022-11-02T11:17:34Z2022-11-02T11:17:34Z20212022-11-02Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2169-2513http://hdl.handle.net/10725/14205https://doi.org/10.4236/ojrm.2021.102002Khalil, C., Chaker, D., Salameh, R., Germanos, Y. E., El Kayem, E., Nader, F., ... & Ibrahim, A. (2021). Autologous Adipose-Derived Mesenchymal Stem Cells Embedded in Platelet-Rich Fibrin in Diabetic Foot Ulcers. Open Journal of Regenerative Medicine, 10(2), 19-30.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://www.scirp.org/journal/paperinformation.aspx?paperid=110795enOpen Journal of Regenerative Medicineinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/142052022-11-02T11:17:47Z |
| spellingShingle | Autologous adipose-derived mesenchymal stem cells embedded in platelet-rich fibrin in diabetic foot ulcers Khalil, Charbel |
| status_str | publishedVersion |
| title | Autologous adipose-derived mesenchymal stem cells embedded in platelet-rich fibrin in diabetic foot ulcers |
| title_full | Autologous adipose-derived mesenchymal stem cells embedded in platelet-rich fibrin in diabetic foot ulcers |
| title_fullStr | Autologous adipose-derived mesenchymal stem cells embedded in platelet-rich fibrin in diabetic foot ulcers |
| title_full_unstemmed | Autologous adipose-derived mesenchymal stem cells embedded in platelet-rich fibrin in diabetic foot ulcers |
| title_short | Autologous adipose-derived mesenchymal stem cells embedded in platelet-rich fibrin in diabetic foot ulcers |
| title_sort | Autologous adipose-derived mesenchymal stem cells embedded in platelet-rich fibrin in diabetic foot ulcers |
| url | http://hdl.handle.net/10725/14205 https://doi.org/10.4236/ojrm.2021.102002 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.scirp.org/journal/paperinformation.aspx?paperid=110795 |