Photoactivatable RuII Complex Bearing 2,9‐Diphenyl‐1,10‐phenanthroline: Unusual Photochemistry and Significant Potency on Cisplatin‐Resistant Cell Lines
The current study investigates [Ru(bipy)2(dpphen)]Cl2 [where bipy = 2,2′‐bipyridine and dpphen = 2,9‐diphenyl‐1,10‐phenanthroline] (complex 1) for photoactivatable chemotherapy (PACT) application on five cancer cell lines. [Ru(bipy)2(phen)]Cl2 [where phen = 1,10‐phenanthroline] (complex 2) was inclu...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , , |
| التنسيق: | article |
| منشور في: |
2018
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/11357 https://doi.org/10.1002/ejic.201800194 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://onlinelibrary.wiley.com/doi/full/10.1002/ejic.201800194 |
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| _version_ | 1864513488672522240 |
|---|---|
| author | Mansour, Najwa |
| author2 | Mehanna, Stephanie Mroueh, Mohamad A. Audi, Hassib Bodman-Smith, Kikki Daher, Costantine F. Taleb, Robin I. El-Sibai, Mirvat Khnayzer, Rony S. |
| author2_role | author author author author author author author author |
| author_facet | Mansour, Najwa Mehanna, Stephanie Mroueh, Mohamad A. Audi, Hassib Bodman-Smith, Kikki Daher, Costantine F. Taleb, Robin I. El-Sibai, Mirvat Khnayzer, Rony S. |
| author_role | author |
| dc.creator.none.fl_str_mv | Mansour, Najwa Mehanna, Stephanie Mroueh, Mohamad A. Audi, Hassib Bodman-Smith, Kikki Daher, Costantine F. Taleb, Robin I. El-Sibai, Mirvat Khnayzer, Rony S. |
| dc.date.none.fl_str_mv | 2018 2019-10-01T13:34:06Z 2019-10-01T13:34:06Z 2019-10-01 |
| dc.identifier.none.fl_str_mv | 1434-1948 http://hdl.handle.net/10725/11357 https://doi.org/10.1002/ejic.201800194 Mansour, N., Mehanna, S., Mroueh, M. A., Audi, H., Bodman‐Smith, K., Daher, C. F., ... & Khnayzer, R. S. (2018). Photoactivatable RuII Complex Bearing 2, 9‐Diphenyl‐1, 10‐phenanthroline: Unusual Photochemistry and Significant Potency on Cisplatin‐Resistant Cell Lines. European Journal of Inorganic Chemistry, 2018(22), 2524-2532. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://onlinelibrary.wiley.com/doi/full/10.1002/ejic.201800194 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | European Journal of Inorganic Chemistry |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Photoactivatable RuII Complex Bearing 2,9‐Diphenyl‐1,10‐phenanthroline: Unusual Photochemistry and Significant Potency on Cisplatin‐Resistant Cell Lines |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | The current study investigates [Ru(bipy)2(dpphen)]Cl2 [where bipy = 2,2′‐bipyridine and dpphen = 2,9‐diphenyl‐1,10‐phenanthroline] (complex 1) for photoactivatable chemotherapy (PACT) application on five cancer cell lines. [Ru(bipy)2(phen)]Cl2 [where phen = 1,10‐phenanthroline] (complex 2) was included as an unstrained control. Upon excitation with visible light, complex 2 proved to be photostable while complex 1 underwent a quantitative dissociation of the bipy ligand and formation of a RuII polypyridyl aqua complex in water. Complex 1 demonstrated only marginal activity in the dark; its cytotoxicity increased significantly upon photoactivation with a high phototoxicity index (PI = [IC50 dark]/[IC50 light]) ranging from 39.2‐fold in A549 to over 100‐fold in MDA‐MB‐231. Complex 2, on the other hand, did not show much difference in anticancer activity between dark and light conditions. Importantly, the IC50 of the photoproduct of complex 1 was several folds lower than that of cisplatin in all tested cell lines. Furthermore, the dissociating ligand (bipy) was biologically inert in almost all cell lines investigated confirming that phototoxicity was mediated primarily by the Ru aqua complex that is released upon irradiation. In conclusion, the Ru‐centered complex 1 could represent a potential photoactivatable chemotherapeutic drug that increases selectivity to tumors and offers alternative treatment in the light of increasing cisplatin resistance. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_7641d65e02afeba603259308eab043bb |
| identifier_str_mv | 1434-1948 Mansour, N., Mehanna, S., Mroueh, M. A., Audi, H., Bodman‐Smith, K., Daher, C. F., ... & Khnayzer, R. S. (2018). Photoactivatable RuII Complex Bearing 2, 9‐Diphenyl‐1, 10‐phenanthroline: Unusual Photochemistry and Significant Potency on Cisplatin‐Resistant Cell Lines. European Journal of Inorganic Chemistry, 2018(22), 2524-2532. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/11357 |
| publishDate | 2018 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Photoactivatable RuII Complex Bearing 2,9‐Diphenyl‐1,10‐phenanthroline: Unusual Photochemistry and Significant Potency on Cisplatin‐Resistant Cell LinesMansour, NajwaMehanna, StephanieMroueh, Mohamad A.Audi, HassibBodman-Smith, KikkiDaher, Costantine F.Taleb, Robin I.El-Sibai, MirvatKhnayzer, Rony S.The current study investigates [Ru(bipy)2(dpphen)]Cl2 [where bipy = 2,2′‐bipyridine and dpphen = 2,9‐diphenyl‐1,10‐phenanthroline] (complex 1) for photoactivatable chemotherapy (PACT) application on five cancer cell lines. [Ru(bipy)2(phen)]Cl2 [where phen = 1,10‐phenanthroline] (complex 2) was included as an unstrained control. Upon excitation with visible light, complex 2 proved to be photostable while complex 1 underwent a quantitative dissociation of the bipy ligand and formation of a RuII polypyridyl aqua complex in water. Complex 1 demonstrated only marginal activity in the dark; its cytotoxicity increased significantly upon photoactivation with a high phototoxicity index (PI = [IC50 dark]/[IC50 light]) ranging from 39.2‐fold in A549 to over 100‐fold in MDA‐MB‐231. Complex 2, on the other hand, did not show much difference in anticancer activity between dark and light conditions. Importantly, the IC50 of the photoproduct of complex 1 was several folds lower than that of cisplatin in all tested cell lines. Furthermore, the dissociating ligand (bipy) was biologically inert in almost all cell lines investigated confirming that phototoxicity was mediated primarily by the Ru aqua complex that is released upon irradiation. In conclusion, the Ru‐centered complex 1 could represent a potential photoactivatable chemotherapeutic drug that increases selectivity to tumors and offers alternative treatment in the light of increasing cisplatin resistance.PublishedN/A2019-10-01T13:34:06Z2019-10-01T13:34:06Z20182019-10-01Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1434-1948http://hdl.handle.net/10725/11357https://doi.org/10.1002/ejic.201800194Mansour, N., Mehanna, S., Mroueh, M. A., Audi, H., Bodman‐Smith, K., Daher, C. F., ... & Khnayzer, R. S. (2018). Photoactivatable RuII Complex Bearing 2, 9‐Diphenyl‐1, 10‐phenanthroline: Unusual Photochemistry and Significant Potency on Cisplatin‐Resistant Cell Lines. European Journal of Inorganic Chemistry, 2018(22), 2524-2532.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://onlinelibrary.wiley.com/doi/full/10.1002/ejic.201800194enEuropean Journal of Inorganic Chemistryinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/113572024-01-30T13:54:30Z |
| spellingShingle | Photoactivatable RuII Complex Bearing 2,9‐Diphenyl‐1,10‐phenanthroline: Unusual Photochemistry and Significant Potency on Cisplatin‐Resistant Cell Lines Mansour, Najwa |
| status_str | publishedVersion |
| title | Photoactivatable RuII Complex Bearing 2,9‐Diphenyl‐1,10‐phenanthroline: Unusual Photochemistry and Significant Potency on Cisplatin‐Resistant Cell Lines |
| title_full | Photoactivatable RuII Complex Bearing 2,9‐Diphenyl‐1,10‐phenanthroline: Unusual Photochemistry and Significant Potency on Cisplatin‐Resistant Cell Lines |
| title_fullStr | Photoactivatable RuII Complex Bearing 2,9‐Diphenyl‐1,10‐phenanthroline: Unusual Photochemistry and Significant Potency on Cisplatin‐Resistant Cell Lines |
| title_full_unstemmed | Photoactivatable RuII Complex Bearing 2,9‐Diphenyl‐1,10‐phenanthroline: Unusual Photochemistry and Significant Potency on Cisplatin‐Resistant Cell Lines |
| title_short | Photoactivatable RuII Complex Bearing 2,9‐Diphenyl‐1,10‐phenanthroline: Unusual Photochemistry and Significant Potency on Cisplatin‐Resistant Cell Lines |
| title_sort | Photoactivatable RuII Complex Bearing 2,9‐Diphenyl‐1,10‐phenanthroline: Unusual Photochemistry and Significant Potency on Cisplatin‐Resistant Cell Lines |
| url | http://hdl.handle.net/10725/11357 https://doi.org/10.1002/ejic.201800194 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://onlinelibrary.wiley.com/doi/full/10.1002/ejic.201800194 |