Effects of left DLPFC versus right PPC tDCS on multiple sclerosis fatigue
Background and objective Fatigue is a frequent and debilitating symptom in patients with multiple sclerosis (MS). Its classical treatments are still faced with limited benefits and numerous side effects. Hence, we aimed to evaluate the effects of transcranial direct current stimulation (tDCS), a non...
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| مؤلفون آخرون: | , , , , , , |
| التنسيق: | article |
| منشور في: |
2017
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/10399 https://doi.org/10.1016/j.jns.2016.11.015 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.sciencedirect.com/science/article/pii/S0022510X16307109#ks0005 |
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| _version_ | 1864513467416838144 |
|---|---|
| author | Ahdab, Rechdi |
| author2 | Chalah, Moussa A. Riachi, Naji Mhalla, Alaa Abdellaoui, Mohamed Creange, Alain Lefaucheur, Jean-Pascal Ayache, Samar S. |
| author2_role | author author author author author author author |
| author_facet | Ahdab, Rechdi Chalah, Moussa A. Riachi, Naji Mhalla, Alaa Abdellaoui, Mohamed Creange, Alain Lefaucheur, Jean-Pascal Ayache, Samar S. |
| author_role | author |
| dc.creator.none.fl_str_mv | Ahdab, Rechdi Chalah, Moussa A. Riachi, Naji Mhalla, Alaa Abdellaoui, Mohamed Creange, Alain Lefaucheur, Jean-Pascal Ayache, Samar S. |
| dc.date.none.fl_str_mv | 2017 2019-04-10T11:20:53Z 2019-04-10T11:20:53Z 2019-04-10 |
| dc.identifier.none.fl_str_mv | 1302-1664 http://hdl.handle.net/10725/10399 https://doi.org/10.1016/j.jns.2016.11.015 Chalah, M. A., Riachi, N., Ahdab, R., Mhalla, A., Abdellaoui, M., Créange, A., ... & Ayache, S. S. (2017). Effects of left DLPFC versus right PPC tDCS on multiple sclerosis fatigue. Journal of the neurological sciences, 372, 131-137. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.sciencedirect.com/science/article/pii/S0022510X16307109#ks0005 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Journal of Neurological Sciences |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Effects of left DLPFC versus right PPC tDCS on multiple sclerosis fatigue |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Background and objective Fatigue is a frequent and debilitating symptom in patients with multiple sclerosis (MS). Its classical treatments are still faced with limited benefits and numerous side effects. Hence, we aimed to evaluate the effects of transcranial direct current stimulation (tDCS), a noninvasive brain stimulation technique, on such a challenging symptom. Our secondary outcomes included the assessment of tDCS impact on mood and attentional performance. Methods Ten fatigued MS patients were enrolled in a double-blind, sham-controlled, and cross-over study. Each patient randomly received three anodal tDCS blocks: active stimulation over the left dorsolateral prefrontal cortex (DLPFC), active stimulation over the right posterior parietal cortex (PPC), and sham stimulation over either cortical site. Both cortical targets are key components in the MS fatigue networks. The blocks consisted of five consecutive daily sessions and were held apart by a washout interval of three weeks. Results Only active left DLPFC stimulation significantly ameliorated fatigue. Mood improvement was exclusively obtained following active right PPC stimulation. Neither intervention had effects on attention. Conclusion Our study supports the role of anodal tDCS over the left prefrontal in treating MS fatigue. The lack of tDCS effects on attention might be related to the heterogeneity of the studied cohort, the relatively small sample size, the protocol design and duration. Modifying these variables and coupling tDCS with neuroimaging might improve the clinical outcomes and enhance our understanding of the tDCS mechanism of actions. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_78109dc010baf341b50bb51fef8d2620 |
| identifier_str_mv | 1302-1664 Chalah, M. A., Riachi, N., Ahdab, R., Mhalla, A., Abdellaoui, M., Créange, A., ... & Ayache, S. S. (2017). Effects of left DLPFC versus right PPC tDCS on multiple sclerosis fatigue. Journal of the neurological sciences, 372, 131-137. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/10399 |
| publishDate | 2017 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Effects of left DLPFC versus right PPC tDCS on multiple sclerosis fatigueAhdab, RechdiChalah, Moussa A.Riachi, NajiMhalla, AlaaAbdellaoui, MohamedCreange, AlainLefaucheur, Jean-PascalAyache, Samar S.Background and objective Fatigue is a frequent and debilitating symptom in patients with multiple sclerosis (MS). Its classical treatments are still faced with limited benefits and numerous side effects. Hence, we aimed to evaluate the effects of transcranial direct current stimulation (tDCS), a noninvasive brain stimulation technique, on such a challenging symptom. Our secondary outcomes included the assessment of tDCS impact on mood and attentional performance. Methods Ten fatigued MS patients were enrolled in a double-blind, sham-controlled, and cross-over study. Each patient randomly received three anodal tDCS blocks: active stimulation over the left dorsolateral prefrontal cortex (DLPFC), active stimulation over the right posterior parietal cortex (PPC), and sham stimulation over either cortical site. Both cortical targets are key components in the MS fatigue networks. The blocks consisted of five consecutive daily sessions and were held apart by a washout interval of three weeks. Results Only active left DLPFC stimulation significantly ameliorated fatigue. Mood improvement was exclusively obtained following active right PPC stimulation. Neither intervention had effects on attention. Conclusion Our study supports the role of anodal tDCS over the left prefrontal in treating MS fatigue. The lack of tDCS effects on attention might be related to the heterogeneity of the studied cohort, the relatively small sample size, the protocol design and duration. Modifying these variables and coupling tDCS with neuroimaging might improve the clinical outcomes and enhance our understanding of the tDCS mechanism of actions.PublishedN/A2019-04-10T11:20:53Z2019-04-10T11:20:53Z20172019-04-10Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1302-1664http://hdl.handle.net/10725/10399https://doi.org/10.1016/j.jns.2016.11.015Chalah, M. A., Riachi, N., Ahdab, R., Mhalla, A., Abdellaoui, M., Créange, A., ... & Ayache, S. S. (2017). Effects of left DLPFC versus right PPC tDCS on multiple sclerosis fatigue. Journal of the neurological sciences, 372, 131-137.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://www.sciencedirect.com/science/article/pii/S0022510X16307109#ks0005enJournal of Neurological Sciencesinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/103992021-03-19T10:45:18Z |
| spellingShingle | Effects of left DLPFC versus right PPC tDCS on multiple sclerosis fatigue Ahdab, Rechdi |
| status_str | publishedVersion |
| title | Effects of left DLPFC versus right PPC tDCS on multiple sclerosis fatigue |
| title_full | Effects of left DLPFC versus right PPC tDCS on multiple sclerosis fatigue |
| title_fullStr | Effects of left DLPFC versus right PPC tDCS on multiple sclerosis fatigue |
| title_full_unstemmed | Effects of left DLPFC versus right PPC tDCS on multiple sclerosis fatigue |
| title_short | Effects of left DLPFC versus right PPC tDCS on multiple sclerosis fatigue |
| title_sort | Effects of left DLPFC versus right PPC tDCS on multiple sclerosis fatigue |
| url | http://hdl.handle.net/10725/10399 https://doi.org/10.1016/j.jns.2016.11.015 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.sciencedirect.com/science/article/pii/S0022510X16307109#ks0005 |