Undetected lymph node metastases in presumed early stage NSCLC SABR patients
Introduction: Stereotactic body radiation therapy (SBRT, also called stereotactic ablative body radiation SABR) is the treatment of choice for many patients with early-stage non-small cell lung cancer (NSCLC), including those who are unfit for surgery or refuse surgery. Areas covered: In an effort t...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , |
| التنسيق: | article |
| منشور في: |
2016
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/10029 https://doi.org/10.1080/14737140.2016.1199279 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.tandfonline.com/doi/abs/10.1080/14737140.2016.1199279 |
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| _version_ | 1864513485767966720 |
|---|---|
| author | Diab, Khalil |
| author2 | Cerra-Franco, Alberto Lautenschlaeger, Tim |
| author2_role | author author |
| author_facet | Diab, Khalil Cerra-Franco, Alberto Lautenschlaeger, Tim |
| author_role | author |
| dc.creator.none.fl_str_mv | Diab, Khalil Cerra-Franco, Alberto Lautenschlaeger, Tim |
| dc.date.none.fl_str_mv | 2016 2019-02-13T09:58:33Z 2019-02-13T09:58:33Z 2019-02-13 |
| dc.identifier.none.fl_str_mv | 1744-8328 http://hdl.handle.net/10725/10029 https://doi.org/10.1080/14737140.2016.1199279 Cerra-Franco, A., Diab, K., & Lautenschlaeger, T. (2016). Undetected lymph node metastases in presumed early stage NSCLC SABR patients. Expert review of anticancer therapy, 16(8), 869-875. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.tandfonline.com/doi/abs/10.1080/14737140.2016.1199279 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Expert Review of Anticancer Therapy |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Undetected lymph node metastases in presumed early stage NSCLC SABR patients |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Introduction: Stereotactic body radiation therapy (SBRT, also called stereotactic ablative body radiation SABR) is the treatment of choice for many patients with early-stage non-small cell lung cancer (NSCLC), including those who are unfit for surgery or refuse surgery. Areas covered: In an effort to develop optimal staging for the evaluation of SBRT candidates, we review the performance of available lymph node staging methods, as well as risk factors for lymph node involvement. Pubmed was searched to identify relevant literature. Current staging methods for NSCLC, including Positron Emission Tomography/Computed Tomography(PET/CT) and endobronchial ultra sound (EBUS), have limited sensitivities. Expert commentary: There are several factors, including primary tumor location, tumor size, and histology that are possibly associated with the sensitivity of PET/CT to detect mediastinal lymph node metastasis. Small lymph node metastases typically remain undetected by PET/CT. Therefore invasive nodal staging procedures are indicated for most presumed early-stage NSCLC patients, but these also have limited sensitivity. Occult lymph node metastasis is associated with adverse outcome in NSCLC. Moreover, there is overwhelming evidence that certain patients who have lymph node metastases detected at the time of surgery derive an overall survival benefit from adjuvant therapies. It remains to be determined if improved detection of lymph node metastases in SABR candidates can indeed improve prognosis. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_7899dbfe747cd3ac614dbdb3066ff07f |
| identifier_str_mv | 1744-8328 Cerra-Franco, A., Diab, K., & Lautenschlaeger, T. (2016). Undetected lymph node metastases in presumed early stage NSCLC SABR patients. Expert review of anticancer therapy, 16(8), 869-875. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/10029 |
| publishDate | 2016 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Undetected lymph node metastases in presumed early stage NSCLC SABR patientsDiab, KhalilCerra-Franco, AlbertoLautenschlaeger, TimIntroduction: Stereotactic body radiation therapy (SBRT, also called stereotactic ablative body radiation SABR) is the treatment of choice for many patients with early-stage non-small cell lung cancer (NSCLC), including those who are unfit for surgery or refuse surgery. Areas covered: In an effort to develop optimal staging for the evaluation of SBRT candidates, we review the performance of available lymph node staging methods, as well as risk factors for lymph node involvement. Pubmed was searched to identify relevant literature. Current staging methods for NSCLC, including Positron Emission Tomography/Computed Tomography(PET/CT) and endobronchial ultra sound (EBUS), have limited sensitivities. Expert commentary: There are several factors, including primary tumor location, tumor size, and histology that are possibly associated with the sensitivity of PET/CT to detect mediastinal lymph node metastasis. Small lymph node metastases typically remain undetected by PET/CT. Therefore invasive nodal staging procedures are indicated for most presumed early-stage NSCLC patients, but these also have limited sensitivity. Occult lymph node metastasis is associated with adverse outcome in NSCLC. Moreover, there is overwhelming evidence that certain patients who have lymph node metastases detected at the time of surgery derive an overall survival benefit from adjuvant therapies. It remains to be determined if improved detection of lymph node metastases in SABR candidates can indeed improve prognosis.PublishedN/A2019-02-13T09:58:33Z2019-02-13T09:58:33Z20162019-02-13Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1744-8328http://hdl.handle.net/10725/10029https://doi.org/10.1080/14737140.2016.1199279Cerra-Franco, A., Diab, K., & Lautenschlaeger, T. (2016). Undetected lymph node metastases in presumed early stage NSCLC SABR patients. Expert review of anticancer therapy, 16(8), 869-875.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://www.tandfonline.com/doi/abs/10.1080/14737140.2016.1199279enExpert Review of Anticancer Therapyinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/100292021-03-19T10:45:31Z |
| spellingShingle | Undetected lymph node metastases in presumed early stage NSCLC SABR patients Diab, Khalil |
| status_str | publishedVersion |
| title | Undetected lymph node metastases in presumed early stage NSCLC SABR patients |
| title_full | Undetected lymph node metastases in presumed early stage NSCLC SABR patients |
| title_fullStr | Undetected lymph node metastases in presumed early stage NSCLC SABR patients |
| title_full_unstemmed | Undetected lymph node metastases in presumed early stage NSCLC SABR patients |
| title_short | Undetected lymph node metastases in presumed early stage NSCLC SABR patients |
| title_sort | Undetected lymph node metastases in presumed early stage NSCLC SABR patients |
| url | http://hdl.handle.net/10725/10029 https://doi.org/10.1080/14737140.2016.1199279 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.tandfonline.com/doi/abs/10.1080/14737140.2016.1199279 |