Antioxidant and anticancer activities of methanolic, ethyl acetate and chloroform extracts of Arum Palaestinum
Phenolic and flavonoid contents, antioxidant and anticancer activities of the methanolic, chloroform and ethyl acetate extracts of Arum Palaestinum were evaluated. The highest phenolic (mg gallic acid equiv./g dry extract) and flavonoid (mg quercetin equiv./g dry extract) contents were observed in t...
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2012
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| Online Access: | http://hdl.handle.net/10725/8426 http://dx.doi.org/10.1055/s-0032-1321076 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0032-1321076 |
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| _version_ | 1864513484627116032 |
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| author | Diab-Assaf, M. |
| author2 | Taleb, RI Shehaby, W. Mansour, A. Daher, C. Mroueh, M. |
| author2_role | author author author author author |
| author_facet | Diab-Assaf, M. Taleb, RI Shehaby, W. Mansour, A. Daher, C. Mroueh, M. |
| author_role | author |
| dc.creator.none.fl_str_mv | Diab-Assaf, M. Taleb, RI Shehaby, W. Mansour, A. Daher, C. Mroueh, M. |
| dc.date.none.fl_str_mv | 2012 2018-09-06T08:59:57Z 2018-09-06T08:59:57Z 2018-09-06 |
| dc.identifier.none.fl_str_mv | 1439-0221 http://hdl.handle.net/10725/8426 http://dx.doi.org/10.1055/s-0032-1321076 Diab-Assaf, M., Taleb, R. I., Shebaby, W., Mansour, A., Moussa, C. J., Daher, C., & Mroueh, M. (2012). Antioxidant and anticancer activities of methanolic, ethyl acetate and chloroform extracts of Arum Palaestinum. Planta Medica, 78(11), PI389. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0032-1321076 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Planta Medica |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Antioxidant and anticancer activities of methanolic, ethyl acetate and chloroform extracts of Arum Palaestinum |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Phenolic and flavonoid contents, antioxidant and anticancer activities of the methanolic, chloroform and ethyl acetate extracts of Arum Palaestinum were evaluated. The highest phenolic (mg gallic acid equiv./g dry extract) and flavonoid (mg quercetin equiv./g dry extract) contents were observed in the methanolic (30. 9±0.2; 14.4±0.8), followed by chloroform (13.7±0.6; 11.9±0.9) and ethyl acetate (5.3±0.6; 8.5±0.8) extracts, respectively. The FRAP and DPPH antioxidant activities were highly correlated with the phenolic's and flavonoid's contents. The antiproliferative effects of the extracts were evaluated against the T cell lymphoblastic leukemia, Jurkat cells at 24 and 48 hr. Results showed a dose dependent reduction in cell proliferation, with more significance at 48 hrs. The IC50 values were (17.5±2.1µg/mL), (19.7±2.8µg/mL) and (23.3±2.8µg/mL) for ethyl acetate, methanol and chloroform extracts, respectively at non-cytotoxic concentrations. The present data suggests a lack of correlation between antioxidant and anticancer activities and further investigation is needed to elucidate the mechanism of action involved and to identify the active components. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_7fdf1de4e0685a787245f117c4c8bf35 |
| identifier_str_mv | 1439-0221 Diab-Assaf, M., Taleb, R. I., Shebaby, W., Mansour, A., Moussa, C. J., Daher, C., & Mroueh, M. (2012). Antioxidant and anticancer activities of methanolic, ethyl acetate and chloroform extracts of Arum Palaestinum. Planta Medica, 78(11), PI389. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/8426 |
| publishDate | 2012 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Antioxidant and anticancer activities of methanolic, ethyl acetate and chloroform extracts of Arum PalaestinumDiab-Assaf, M.Taleb, RIShehaby, W.Mansour, A.Daher, C.Mroueh, M.Phenolic and flavonoid contents, antioxidant and anticancer activities of the methanolic, chloroform and ethyl acetate extracts of Arum Palaestinum were evaluated. The highest phenolic (mg gallic acid equiv./g dry extract) and flavonoid (mg quercetin equiv./g dry extract) contents were observed in the methanolic (30. 9±0.2; 14.4±0.8), followed by chloroform (13.7±0.6; 11.9±0.9) and ethyl acetate (5.3±0.6; 8.5±0.8) extracts, respectively. The FRAP and DPPH antioxidant activities were highly correlated with the phenolic's and flavonoid's contents. The antiproliferative effects of the extracts were evaluated against the T cell lymphoblastic leukemia, Jurkat cells at 24 and 48 hr. Results showed a dose dependent reduction in cell proliferation, with more significance at 48 hrs. The IC50 values were (17.5±2.1µg/mL), (19.7±2.8µg/mL) and (23.3±2.8µg/mL) for ethyl acetate, methanol and chloroform extracts, respectively at non-cytotoxic concentrations. The present data suggests a lack of correlation between antioxidant and anticancer activities and further investigation is needed to elucidate the mechanism of action involved and to identify the active components.PublishedN/A2018-09-06T08:59:57Z2018-09-06T08:59:57Z20122018-09-06Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1439-0221http://hdl.handle.net/10725/8426http://dx.doi.org/10.1055/s-0032-1321076Diab-Assaf, M., Taleb, R. I., Shebaby, W., Mansour, A., Moussa, C. J., Daher, C., & Mroueh, M. (2012). Antioxidant and anticancer activities of methanolic, ethyl acetate and chloroform extracts of Arum Palaestinum. Planta Medica, 78(11), PI389.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0032-1321076enPlanta Medicainfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/84262024-01-30T13:23:04Z |
| spellingShingle | Antioxidant and anticancer activities of methanolic, ethyl acetate and chloroform extracts of Arum Palaestinum Diab-Assaf, M. |
| status_str | publishedVersion |
| title | Antioxidant and anticancer activities of methanolic, ethyl acetate and chloroform extracts of Arum Palaestinum |
| title_full | Antioxidant and anticancer activities of methanolic, ethyl acetate and chloroform extracts of Arum Palaestinum |
| title_fullStr | Antioxidant and anticancer activities of methanolic, ethyl acetate and chloroform extracts of Arum Palaestinum |
| title_full_unstemmed | Antioxidant and anticancer activities of methanolic, ethyl acetate and chloroform extracts of Arum Palaestinum |
| title_short | Antioxidant and anticancer activities of methanolic, ethyl acetate and chloroform extracts of Arum Palaestinum |
| title_sort | Antioxidant and anticancer activities of methanolic, ethyl acetate and chloroform extracts of Arum Palaestinum |
| url | http://hdl.handle.net/10725/8426 http://dx.doi.org/10.1055/s-0032-1321076 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0032-1321076 |