Genome-Wide Association Study in a Lebanese Cohort Confirms PHACTR1 as a Major Determinant of Coronary Artery Stenosis
The manifestation of coronary artery disease (CAD) follows a well-choreographed series of events that includes damage of arterial endothelial cells and deposition of lipids in the sub-endothelial layers. Genome-wide association studies (GWAS) of multiple populations with distinctive genetic and life...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , , , , , , , |
| التنسيق: | article |
| منشور في: |
2012
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/3351 http://dx.doi.org/10.1371/journal.pone.0038663 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380020/ |
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| _version_ | 1864513460996407296 |
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| author | Hager, Jorg |
| author2 | Kamatani, Yoichiro Cazier, Jean-Baptiste Youhanna, Sonia Ghassibe-Sabbagh, Michella Platt, Daniel E. Abchee, Antoine B. Romanos, Jihane Khazen, Georges Othman, Raed Badro, Danielle A. Haber, Marc Salloum, Angelique K. Zalloua, Pierre A. |
| author2_role | author author author author author author author author author author author author author |
| author_facet | Hager, Jorg Kamatani, Yoichiro Cazier, Jean-Baptiste Youhanna, Sonia Ghassibe-Sabbagh, Michella Platt, Daniel E. Abchee, Antoine B. Romanos, Jihane Khazen, Georges Othman, Raed Badro, Danielle A. Haber, Marc Salloum, Angelique K. Zalloua, Pierre A. |
| author_role | author |
| dc.creator.none.fl_str_mv | Hager, Jorg Kamatani, Yoichiro Cazier, Jean-Baptiste Youhanna, Sonia Ghassibe-Sabbagh, Michella Platt, Daniel E. Abchee, Antoine B. Romanos, Jihane Khazen, Georges Othman, Raed Badro, Danielle A. Haber, Marc Salloum, Angelique K. Zalloua, Pierre A. |
| dc.date.none.fl_str_mv | 2012 2016-03-17T10:53:57Z 2016-03-17T10:53:57Z 2016-03-17 |
| dc.identifier.none.fl_str_mv | 1932-6203 http://hdl.handle.net/10725/3351 http://dx.doi.org/10.1371/journal.pone.0038663 Hager, J., Kamatani, Y., Cazier, J. B., Youhanna, S., Ghassibe-Sabbagh, M., Platt, D. E., ... & Badro, D. A. (2012). Genome-wide association study in a Lebanese cohort confirms PHACTR1 as a major determinant of coronary artery stenosis. PloS one, 7(6). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380020/ |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | PLOS One |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Genome-Wide Association Study in a Lebanese Cohort Confirms PHACTR1 as a Major Determinant of Coronary Artery Stenosis |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | The manifestation of coronary artery disease (CAD) follows a well-choreographed series of events that includes damage of arterial endothelial cells and deposition of lipids in the sub-endothelial layers. Genome-wide association studies (GWAS) of multiple populations with distinctive genetic and lifestyle backgrounds are a crucial step in understanding global CAD pathophysiology. In this study, we report a GWAS on the genetic basis of arterial stenosis as measured by cardiac catheterization in a Lebanese population. The locus of the phosphatase and actin regulator 1 gene (PHACTR1) showed association with coronary stenosis in a discovery experiment with genome wide data in 1,949 individuals (rs9349379, OR = 1.37, p = 1.57×10−5). The association was replicated in an additional 2,547 individuals (OR = 1.31, p = 8.85×10−6), leading to genome-wide significant association in a combined analysis (OR = 1.34, p = 8.02×10−10). Results from this GWAS support a central role of PHACTR1 in CAD susceptibility irrespective of lifestyle and ethnic divergences. This association provides a plausible component for understanding molecular mechanisms involved in the formation of stenosis in cardiac vessels and a potential drug target against CAD. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_8162d14c02774b362c7b383bbdeeeff7 |
| identifier_str_mv | 1932-6203 Hager, J., Kamatani, Y., Cazier, J. B., Youhanna, S., Ghassibe-Sabbagh, M., Platt, D. E., ... & Badro, D. A. (2012). Genome-wide association study in a Lebanese cohort confirms PHACTR1 as a major determinant of coronary artery stenosis. PloS one, 7(6). |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/3351 |
| publishDate | 2012 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Genome-Wide Association Study in a Lebanese Cohort Confirms PHACTR1 as a Major Determinant of Coronary Artery StenosisHager, JorgKamatani, YoichiroCazier, Jean-BaptisteYouhanna, SoniaGhassibe-Sabbagh, MichellaPlatt, Daniel E.Abchee, Antoine B.Romanos, JihaneKhazen, GeorgesOthman, RaedBadro, Danielle A.Haber, MarcSalloum, Angelique K.Zalloua, Pierre A.The manifestation of coronary artery disease (CAD) follows a well-choreographed series of events that includes damage of arterial endothelial cells and deposition of lipids in the sub-endothelial layers. Genome-wide association studies (GWAS) of multiple populations with distinctive genetic and lifestyle backgrounds are a crucial step in understanding global CAD pathophysiology. In this study, we report a GWAS on the genetic basis of arterial stenosis as measured by cardiac catheterization in a Lebanese population. The locus of the phosphatase and actin regulator 1 gene (PHACTR1) showed association with coronary stenosis in a discovery experiment with genome wide data in 1,949 individuals (rs9349379, OR = 1.37, p = 1.57×10−5). The association was replicated in an additional 2,547 individuals (OR = 1.31, p = 8.85×10−6), leading to genome-wide significant association in a combined analysis (OR = 1.34, p = 8.02×10−10). Results from this GWAS support a central role of PHACTR1 in CAD susceptibility irrespective of lifestyle and ethnic divergences. This association provides a plausible component for understanding molecular mechanisms involved in the formation of stenosis in cardiac vessels and a potential drug target against CAD.PublishedN/A2016-03-17T10:53:57Z2016-03-17T10:53:57Z20122016-03-17Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1932-6203http://hdl.handle.net/10725/3351http://dx.doi.org/10.1371/journal.pone.0038663Hager, J., Kamatani, Y., Cazier, J. B., Youhanna, S., Ghassibe-Sabbagh, M., Platt, D. E., ... & Badro, D. A. (2012). Genome-wide association study in a Lebanese cohort confirms PHACTR1 as a major determinant of coronary artery stenosis. PloS one, 7(6).https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380020/enPLOS Oneinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/33512020-02-13T13:56:38Z |
| spellingShingle | Genome-Wide Association Study in a Lebanese Cohort Confirms PHACTR1 as a Major Determinant of Coronary Artery Stenosis Hager, Jorg |
| status_str | publishedVersion |
| title | Genome-Wide Association Study in a Lebanese Cohort Confirms PHACTR1 as a Major Determinant of Coronary Artery Stenosis |
| title_full | Genome-Wide Association Study in a Lebanese Cohort Confirms PHACTR1 as a Major Determinant of Coronary Artery Stenosis |
| title_fullStr | Genome-Wide Association Study in a Lebanese Cohort Confirms PHACTR1 as a Major Determinant of Coronary Artery Stenosis |
| title_full_unstemmed | Genome-Wide Association Study in a Lebanese Cohort Confirms PHACTR1 as a Major Determinant of Coronary Artery Stenosis |
| title_short | Genome-Wide Association Study in a Lebanese Cohort Confirms PHACTR1 as a Major Determinant of Coronary Artery Stenosis |
| title_sort | Genome-Wide Association Study in a Lebanese Cohort Confirms PHACTR1 as a Major Determinant of Coronary Artery Stenosis |
| url | http://hdl.handle.net/10725/3351 http://dx.doi.org/10.1371/journal.pone.0038663 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380020/ |