Biallelic inactivation of the APC gene is associated with hepatocellular carcinoma in familial adenomatous polyposis coli
BACKGROUND Certain primary hepatic tumors have been associated with familial adenomatous polyposis (FAP), a condition caused by germline mutations of the adenomatous polyposis coli (APC) gene. However, a genetic association between FAP and hepatocellular carcinoma (HCC) has not been shown. This stud...
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2001
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| Online Access: | http://hdl.handle.net/10725/2507 http://dx.doi.org/10.1002/1097-0142(20010715)92:2<332::AID-CNCR1327>3.0.CO;2-3 https://acsjournals.onlinelibrary.wiley.com/doi/full/10.1002/1097-0142%2820010715%2992%3A2%3C332%3A%3AAID-CNCR1327%3E3.0.CO%3B2-3 |
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| _version_ | 1864513458542739456 |
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| author | Su, Li-Kuo |
| author2 | Abdalla, Eddie K. Law, Calvin H. L. Kohlmann, Wendy Rashid, Asif Vauthey, Jean-Nicolas |
| author2_role | author author author author author |
| author_facet | Su, Li-Kuo Abdalla, Eddie K. Law, Calvin H. L. Kohlmann, Wendy Rashid, Asif Vauthey, Jean-Nicolas |
| author_role | author |
| dc.creator.none.fl_str_mv | Su, Li-Kuo Abdalla, Eddie K. Law, Calvin H. L. Kohlmann, Wendy Rashid, Asif Vauthey, Jean-Nicolas |
| dc.date.none.fl_str_mv | 2001 2001-07-16 2015-11-10T09:10:33Z 2015-11-10T09:10:33Z |
| dc.identifier.none.fl_str_mv | 0008-543X http://hdl.handle.net/10725/2507 http://dx.doi.org/10.1002/1097-0142(20010715)92:2<332::AID-CNCR1327>3.0.CO;2-3 Su, L. K., Abdalla, E. K., Law, C. H., Kohlmann, W., Rashid, A., & Vauthey, J. N. (2001). Biallelic inactivation of the APC gene is associated with hepatocellular carcinoma in familial adenomatous polyposis coli. Cancer, 92(2), 332-339. https://acsjournals.onlinelibrary.wiley.com/doi/full/10.1002/1097-0142%2820010715%2992%3A2%3C332%3A%3AAID-CNCR1327%3E3.0.CO%3B2-3 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Cancer |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Biallelic inactivation of the APC gene is associated with hepatocellular carcinoma in familial adenomatous polyposis coli |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | BACKGROUND Certain primary hepatic tumors have been associated with familial adenomatous polyposis (FAP), a condition caused by germline mutations of the adenomatous polyposis coli (APC) gene. However, a genetic association between FAP and hepatocellular carcinoma (HCC) has not been shown. This study tested the hypothesis that biallelic inactivation of the APC gene contributed to the development of HCC in a patient with FAP and a known germline mutation of the APC gene at codon 208, but no other risk factors for HCC. METHODS Total RNA and genomic DNA were isolated from the tumor, and in vitro synthesized protein assay and DNA sequencing analysis were used to screen for a somatic mutation in the APC gene. RESULTS A somatic one–base pair deletion at codon 568 was identified in the wild-type allele of the APC gene. CONCLUSIONS To the authors' knowledge, this study provides the first evidence that biallelic inactivation of the APC gene may contribute to the development of HCC in patients with FAP. Cancer 2001;92:332–9. © 2001 American Cancer Society. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_81a9419fa9d9cff8aa10c7b68d1db603 |
| identifier_str_mv | 0008-543X Su, L. K., Abdalla, E. K., Law, C. H., Kohlmann, W., Rashid, A., & Vauthey, J. N. (2001). Biallelic inactivation of the APC gene is associated with hepatocellular carcinoma in familial adenomatous polyposis coli. Cancer, 92(2), 332-339. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/2507 |
| publishDate | 2001 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Biallelic inactivation of the APC gene is associated with hepatocellular carcinoma in familial adenomatous polyposis coliSu, Li-KuoAbdalla, Eddie K.Law, Calvin H. L.Kohlmann, WendyRashid, AsifVauthey, Jean-NicolasBACKGROUND Certain primary hepatic tumors have been associated with familial adenomatous polyposis (FAP), a condition caused by germline mutations of the adenomatous polyposis coli (APC) gene. However, a genetic association between FAP and hepatocellular carcinoma (HCC) has not been shown. This study tested the hypothesis that biallelic inactivation of the APC gene contributed to the development of HCC in a patient with FAP and a known germline mutation of the APC gene at codon 208, but no other risk factors for HCC. METHODS Total RNA and genomic DNA were isolated from the tumor, and in vitro synthesized protein assay and DNA sequencing analysis were used to screen for a somatic mutation in the APC gene. RESULTS A somatic one–base pair deletion at codon 568 was identified in the wild-type allele of the APC gene. CONCLUSIONS To the authors' knowledge, this study provides the first evidence that biallelic inactivation of the APC gene may contribute to the development of HCC in patients with FAP. Cancer 2001;92:332–9. © 2001 American Cancer Society.PublishedN/A2015-11-10T09:10:33Z2015-11-10T09:10:33Z20012001-07-16Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0008-543Xhttp://hdl.handle.net/10725/2507http://dx.doi.org/10.1002/1097-0142(20010715)92:2<332::AID-CNCR1327>3.0.CO;2-3Su, L. K., Abdalla, E. K., Law, C. H., Kohlmann, W., Rashid, A., & Vauthey, J. N. (2001). Biallelic inactivation of the APC gene is associated with hepatocellular carcinoma in familial adenomatous polyposis coli. Cancer, 92(2), 332-339.https://acsjournals.onlinelibrary.wiley.com/doi/full/10.1002/1097-0142%2820010715%2992%3A2%3C332%3A%3AAID-CNCR1327%3E3.0.CO%3B2-3enCancerinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/25072025-10-22T09:59:08Z |
| spellingShingle | Biallelic inactivation of the APC gene is associated with hepatocellular carcinoma in familial adenomatous polyposis coli Su, Li-Kuo |
| status_str | publishedVersion |
| title | Biallelic inactivation of the APC gene is associated with hepatocellular carcinoma in familial adenomatous polyposis coli |
| title_full | Biallelic inactivation of the APC gene is associated with hepatocellular carcinoma in familial adenomatous polyposis coli |
| title_fullStr | Biallelic inactivation of the APC gene is associated with hepatocellular carcinoma in familial adenomatous polyposis coli |
| title_full_unstemmed | Biallelic inactivation of the APC gene is associated with hepatocellular carcinoma in familial adenomatous polyposis coli |
| title_short | Biallelic inactivation of the APC gene is associated with hepatocellular carcinoma in familial adenomatous polyposis coli |
| title_sort | Biallelic inactivation of the APC gene is associated with hepatocellular carcinoma in familial adenomatous polyposis coli |
| url | http://hdl.handle.net/10725/2507 http://dx.doi.org/10.1002/1097-0142(20010715)92:2<332::AID-CNCR1327>3.0.CO;2-3 https://acsjournals.onlinelibrary.wiley.com/doi/full/10.1002/1097-0142%2820010715%2992%3A2%3C332%3A%3AAID-CNCR1327%3E3.0.CO%3B2-3 |