New GABAergic interneurons in the adult neocortex and striatum are generated from different precursors
Ongoing neurogenesis in the adult mammalian dentate gyrus and olfactory bulb is generally accepted, but its existence in other adult brain regions is highly controversial. We labeled newly born cells in adult rats with the S-phase marker bromodeoxyuridine (BrdU) and used neuronal markers to characte...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , |
| التنسيق: | article |
| منشور في: |
2005
|
| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/4424 http://dx.doi.org/10.1083/jcb.200407053 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://jcb.rupress.org/content/168/3/415.short |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513463574855680 |
|---|---|
| author | Dayer, Alexandre G. |
| author2 | Cleaver, Kathryn M. Abouantoun, Thamara Camerin, Heather A. |
| author2_role | author author author |
| author_facet | Dayer, Alexandre G. Cleaver, Kathryn M. Abouantoun, Thamara Camerin, Heather A. |
| author_role | author |
| dc.creator.none.fl_str_mv | Dayer, Alexandre G. Cleaver, Kathryn M. Abouantoun, Thamara Camerin, Heather A. |
| dc.date.none.fl_str_mv | 2005 2016-09-27T10:18:12Z 2016-09-27T10:18:12Z 2016-09-27 |
| dc.identifier.none.fl_str_mv | 0021-9525 http://hdl.handle.net/10725/4424 http://dx.doi.org/10.1083/jcb.200407053 Dayer, A. G., Cleaver, K. M., Abouantoun, T., & Cameron, H. A. (2005). New GABAergic interneurons in the adult neocortex and striatum are generated from different precursors. The Journal of cell biology, 168(3), 415-427. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://jcb.rupress.org/content/168/3/415.short |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Journal of Cell Biology |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | New GABAergic interneurons in the adult neocortex and striatum are generated from different precursors |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Ongoing neurogenesis in the adult mammalian dentate gyrus and olfactory bulb is generally accepted, but its existence in other adult brain regions is highly controversial. We labeled newly born cells in adult rats with the S-phase marker bromodeoxyuridine (BrdU) and used neuronal markers to characterize new cells at different time points after cell division. In the neocortex and striatum, we found BrdU-labeled cells that expressed each of the eight neuronal markers. Their size as well as staining for γ-aminobutyric acid (GABA), glutamic acid decarboxylase 67, calretinin and/or calbindin, suggest that new neurons in both regions are GABAergic interneurons. BrdU and doublecortin-immunoreactive (BrdU+/DCX+) cells were seen within the striatum, suggesting migration of immature neurons from the subventricular zone. Surprisingly, no DCX+ cells were found within the neocortex. NG2 immunoreactivity in some new neocortical neurons suggested that they may instead be generated from the NG2+ precursors that reside within the cortex itself. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_83017fe0a848353bf76a1c8fc4a0e5a4 |
| identifier_str_mv | 0021-9525 Dayer, A. G., Cleaver, K. M., Abouantoun, T., & Cameron, H. A. (2005). New GABAergic interneurons in the adult neocortex and striatum are generated from different precursors. The Journal of cell biology, 168(3), 415-427. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/4424 |
| publishDate | 2005 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | New GABAergic interneurons in the adult neocortex and striatum are generated from different precursorsDayer, Alexandre G.Cleaver, Kathryn M.Abouantoun, ThamaraCamerin, Heather A.Ongoing neurogenesis in the adult mammalian dentate gyrus and olfactory bulb is generally accepted, but its existence in other adult brain regions is highly controversial. We labeled newly born cells in adult rats with the S-phase marker bromodeoxyuridine (BrdU) and used neuronal markers to characterize new cells at different time points after cell division. In the neocortex and striatum, we found BrdU-labeled cells that expressed each of the eight neuronal markers. Their size as well as staining for γ-aminobutyric acid (GABA), glutamic acid decarboxylase 67, calretinin and/or calbindin, suggest that new neurons in both regions are GABAergic interneurons. BrdU and doublecortin-immunoreactive (BrdU+/DCX+) cells were seen within the striatum, suggesting migration of immature neurons from the subventricular zone. Surprisingly, no DCX+ cells were found within the neocortex. NG2 immunoreactivity in some new neocortical neurons suggested that they may instead be generated from the NG2+ precursors that reside within the cortex itself.PublishedN/A2016-09-27T10:18:12Z2016-09-27T10:18:12Z20052016-09-27Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0021-9525http://hdl.handle.net/10725/4424http://dx.doi.org/10.1083/jcb.200407053Dayer, A. G., Cleaver, K. M., Abouantoun, T., & Cameron, H. A. (2005). New GABAergic interneurons in the adult neocortex and striatum are generated from different precursors. The Journal of cell biology, 168(3), 415-427.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttp://jcb.rupress.org/content/168/3/415.shortenJournal of Cell Biologyinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/44242021-03-19T10:00:52Z |
| spellingShingle | New GABAergic interneurons in the adult neocortex and striatum are generated from different precursors Dayer, Alexandre G. |
| status_str | publishedVersion |
| title | New GABAergic interneurons in the adult neocortex and striatum are generated from different precursors |
| title_full | New GABAergic interneurons in the adult neocortex and striatum are generated from different precursors |
| title_fullStr | New GABAergic interneurons in the adult neocortex and striatum are generated from different precursors |
| title_full_unstemmed | New GABAergic interneurons in the adult neocortex and striatum are generated from different precursors |
| title_short | New GABAergic interneurons in the adult neocortex and striatum are generated from different precursors |
| title_sort | New GABAergic interneurons in the adult neocortex and striatum are generated from different precursors |
| url | http://hdl.handle.net/10725/4424 http://dx.doi.org/10.1083/jcb.200407053 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://jcb.rupress.org/content/168/3/415.short |