Role of cytokines and platelet-activating factor in inflammatory bowel disease
BACKGROUND: Platelet-activating factor (PAF) and cytokines, such as interleukins, tumor necrosis factor, and others, are thought to play a role in the inflammatory process involving gastrointestinal disorders such as Crohn's disease, ulcerative colitis, ischemic colitis, or antibiotic-associate...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , |
| التنسيق: | article |
| منشور في: |
1996
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/6446 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://link.springer.com/article/10.1007%2FBF02068079?LI=true |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513479817297920 |
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| author | Nassif, Anis |
| author2 | Longo, Walter E. Mazuski, John E. Vernava, Anthony M. Kaminski, Donald L. |
| author2_role | author author author author |
| author_facet | Nassif, Anis Longo, Walter E. Mazuski, John E. Vernava, Anthony M. Kaminski, Donald L. |
| author_role | author |
| dc.creator.none.fl_str_mv | Nassif, Anis Longo, Walter E. Mazuski, John E. Vernava, Anthony M. Kaminski, Donald L. |
| dc.date.none.fl_str_mv | 1996 2017-11-01T07:28:37Z 2017-11-01T07:28:37Z 2017-11-01 |
| dc.identifier.none.fl_str_mv | 1530-0358 http://hdl.handle.net/10725/6446 Nassif, A., Longo, W. E., Mazuski, J. E., Vernava, A. M., & Kaminski, D. L. (1996). Role of cytokines and platelet-activating factor in inflammatory bowel disease. Diseases of the colon & rectum, 39(2), 217-223. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://link.springer.com/article/10.1007%2FBF02068079?LI=true |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Diseases of the Colon & Rectum |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Role of cytokines and platelet-activating factor in inflammatory bowel disease |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | BACKGROUND: Platelet-activating factor (PAF) and cytokines, such as interleukins, tumor necrosis factor, and others, are thought to play a role in the inflammatory process involving gastrointestinal disorders such as Crohn's disease, ulcerative colitis, ischemic colitis, or antibiotic-associated colitis. PURPOSE: This study was undertaken to review the latest literature on the role of PAF and cytokines in the genesis of inflammatory bowel disease and implications for therapy and management. RESULTS: PAF is an endogenous phospholipid involved in hypersensitivity and inflammatory reactions such as platelet and neutrophil aggregation, vasodilation, increased vascular permeability, and leukocyte adhesion, which have been associated with inflammatory processes. Cytokines are peptides that regulate and coordinate inflammatory and immunologic responses. Increased production of cytokines has been reported during Crohn's disease and ulcerative colitis and is correlated with disease activity. CONCLUSIONS: Because PAF and cytokines may have an important role in the pathogenesis of inflammatory bowel disease, their inhibition by specific antagonists, mediators, or other agents such as steroids may have a potential therapeutic benefit in treatment and management of these inflammatory diseases in the near future. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_8539b98b34459506ef6db936e850fa7a |
| identifier_str_mv | 1530-0358 Nassif, A., Longo, W. E., Mazuski, J. E., Vernava, A. M., & Kaminski, D. L. (1996). Role of cytokines and platelet-activating factor in inflammatory bowel disease. Diseases of the colon & rectum, 39(2), 217-223. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/6446 |
| publishDate | 1996 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Role of cytokines and platelet-activating factor in inflammatory bowel diseaseNassif, AnisLongo, Walter E.Mazuski, John E.Vernava, Anthony M.Kaminski, Donald L.BACKGROUND: Platelet-activating factor (PAF) and cytokines, such as interleukins, tumor necrosis factor, and others, are thought to play a role in the inflammatory process involving gastrointestinal disorders such as Crohn's disease, ulcerative colitis, ischemic colitis, or antibiotic-associated colitis. PURPOSE: This study was undertaken to review the latest literature on the role of PAF and cytokines in the genesis of inflammatory bowel disease and implications for therapy and management. RESULTS: PAF is an endogenous phospholipid involved in hypersensitivity and inflammatory reactions such as platelet and neutrophil aggregation, vasodilation, increased vascular permeability, and leukocyte adhesion, which have been associated with inflammatory processes. Cytokines are peptides that regulate and coordinate inflammatory and immunologic responses. Increased production of cytokines has been reported during Crohn's disease and ulcerative colitis and is correlated with disease activity. CONCLUSIONS: Because PAF and cytokines may have an important role in the pathogenesis of inflammatory bowel disease, their inhibition by specific antagonists, mediators, or other agents such as steroids may have a potential therapeutic benefit in treatment and management of these inflammatory diseases in the near future.PublishedN/A2017-11-01T07:28:37Z2017-11-01T07:28:37Z19962017-11-01Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1530-0358http://hdl.handle.net/10725/6446Nassif, A., Longo, W. E., Mazuski, J. E., Vernava, A. M., & Kaminski, D. L. (1996). Role of cytokines and platelet-activating factor in inflammatory bowel disease. Diseases of the colon & rectum, 39(2), 217-223.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://link.springer.com/article/10.1007%2FBF02068079?LI=trueenDiseases of the Colon & Rectuminfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/64462021-03-19T10:03:28Z |
| spellingShingle | Role of cytokines and platelet-activating factor in inflammatory bowel disease Nassif, Anis |
| status_str | publishedVersion |
| title | Role of cytokines and platelet-activating factor in inflammatory bowel disease |
| title_full | Role of cytokines and platelet-activating factor in inflammatory bowel disease |
| title_fullStr | Role of cytokines and platelet-activating factor in inflammatory bowel disease |
| title_full_unstemmed | Role of cytokines and platelet-activating factor in inflammatory bowel disease |
| title_short | Role of cytokines and platelet-activating factor in inflammatory bowel disease |
| title_sort | Role of cytokines and platelet-activating factor in inflammatory bowel disease |
| url | http://hdl.handle.net/10725/6446 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://link.springer.com/article/10.1007%2FBF02068079?LI=true |