Nicotine induces resilience to chronic social defeat stress in a mouse model of water pipe tobacco exposure by activating BDNF signaling
The purpose of this study was to investigate how nicotine in the context of water pipe tobacco smoking (WTS) affects depression and anxiety-like behaviors associated with chronic social defeat stress (CSDS). Male C57BL/6 J mice were exposed to WTS or received intraperitoneal injections of nicotine f...
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2020
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| Online Access: | http://hdl.handle.net/10725/14359 https://doi.org/10.1016/j.bbr.2020.112499 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.sciencedirect.com/science/article/pii/S0166432819318212 |
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| _version_ | 1864513469273866240 |
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| author | Khalifeh, Mohamad |
| author2 | Hobeika, Rouba El Hayek, Lauretta Saad, Joelle Eid, Fadi El-Khoury, Reine Ghayad, Litsa-Maria Jabre, Vanessa Nasrallah, Patrick Barmo, Nour Stephan, Joseph S. Khnayzer, Rony Christian, Khalil Sleiman, Sama F. |
| author2_role | author author author author author author author author author author author author author |
| author_facet | Khalifeh, Mohamad Hobeika, Rouba El Hayek, Lauretta Saad, Joelle Eid, Fadi El-Khoury, Reine Ghayad, Litsa-Maria Jabre, Vanessa Nasrallah, Patrick Barmo, Nour Stephan, Joseph S. Khnayzer, Rony Christian, Khalil Sleiman, Sama F. |
| author_role | author |
| dc.creator.none.fl_str_mv | Khalifeh, Mohamad Hobeika, Rouba El Hayek, Lauretta Saad, Joelle Eid, Fadi El-Khoury, Reine Ghayad, Litsa-Maria Jabre, Vanessa Nasrallah, Patrick Barmo, Nour Stephan, Joseph S. Khnayzer, Rony Christian, Khalil Sleiman, Sama F. |
| dc.date.none.fl_str_mv | 2020 2023-01-12T10:42:18Z 2023-01-12T10:42:18Z 2023-01-12 |
| dc.identifier.none.fl_str_mv | 0166-4328 http://hdl.handle.net/10725/14359 https://doi.org/10.1016/j.bbr.2020.112499 Khalifeh, M., Hobeika, R., El Hayek, L., Saad, J., Eid, F., El-Khoury, R., ... & Sleiman, S. F. (2020). Nicotine induces resilience to chronic social defeat stress in a mouse model of water pipe tobacco exposure by activating BDNF signaling. Behavioural Brain Research, 382, 112499. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.sciencedirect.com/science/article/pii/S0166432819318212 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Behavioural Brain Research |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Nicotine induces resilience to chronic social defeat stress in a mouse model of water pipe tobacco exposure by activating BDNF signaling |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | The purpose of this study was to investigate how nicotine in the context of water pipe tobacco smoking (WTS) affects depression and anxiety-like behaviors associated with chronic social defeat stress (CSDS). Male C57BL/6 J mice were exposed to WTS or received intraperitoneal injections of nicotine for thirty days then subjected to CSDS for ten days. During CSDS, mice were exposed to WTS or received nicotine injections. The social interaction and open-field tests were used to classify animals as resilient or susceptible to stress and to evaluate their anxiety-like behavior. After behavioral testing, mice continued to be exposed to WTS/nicotine for ten days and their behavior was reexamined. The involvement of brain derived neurotrophic factor signaling in the nicotine-mediated effects was assessed with the tropomyosin receptor kinase B (TRKB) inhibitor, ANA-12. We found that WTS promotes resilience to stress and rescues social avoidance. Even though WTS initially decreased anxiety-like behaviors, prolonged exposure after the completion of CSDS significantly induced anxiety-like behaviors. Finally, we showed that nicotine mediates the effects of WTS only on resilience to stress by increasing BDNF and TRKB levels and signaling. Our results suggest that the pathways mediating resilience to stress and anxiety are distinct and that nicotine mediates the effects of WTS on social behavior, but not anxiety, by activating BDNF signaling. Significance statement: This study reports the positive effect of WTS and nicotine on social behavior. Furthermore, it shows the negative effects of prolonged WTS on anxiety-like behaviors and suggests that these effects are not necessarily mediated by nicotine. Finally, it identifies BDNF/TRKB signaling pathway as a major mediator of the positive effects of nicotine on social interaction. As a result, this work emphasizes the importance of considering the activation status of this signaling pathway when developing smoking cessation strategies. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_86b8cfc0dce89680457c7093a02c5607 |
| identifier_str_mv | 0166-4328 Khalifeh, M., Hobeika, R., El Hayek, L., Saad, J., Eid, F., El-Khoury, R., ... & Sleiman, S. F. (2020). Nicotine induces resilience to chronic social defeat stress in a mouse model of water pipe tobacco exposure by activating BDNF signaling. Behavioural Brain Research, 382, 112499. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/14359 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Nicotine induces resilience to chronic social defeat stress in a mouse model of water pipe tobacco exposure by activating BDNF signalingKhalifeh, MohamadHobeika, RoubaEl Hayek, LaurettaSaad, JoelleEid, FadiEl-Khoury, ReineGhayad, Litsa-MariaJabre, VanessaNasrallah, PatrickBarmo, NourStephan, Joseph S.Khnayzer, RonyChristian, KhalilSleiman, Sama F.The purpose of this study was to investigate how nicotine in the context of water pipe tobacco smoking (WTS) affects depression and anxiety-like behaviors associated with chronic social defeat stress (CSDS). Male C57BL/6 J mice were exposed to WTS or received intraperitoneal injections of nicotine for thirty days then subjected to CSDS for ten days. During CSDS, mice were exposed to WTS or received nicotine injections. The social interaction and open-field tests were used to classify animals as resilient or susceptible to stress and to evaluate their anxiety-like behavior. After behavioral testing, mice continued to be exposed to WTS/nicotine for ten days and their behavior was reexamined. The involvement of brain derived neurotrophic factor signaling in the nicotine-mediated effects was assessed with the tropomyosin receptor kinase B (TRKB) inhibitor, ANA-12. We found that WTS promotes resilience to stress and rescues social avoidance. Even though WTS initially decreased anxiety-like behaviors, prolonged exposure after the completion of CSDS significantly induced anxiety-like behaviors. Finally, we showed that nicotine mediates the effects of WTS only on resilience to stress by increasing BDNF and TRKB levels and signaling. Our results suggest that the pathways mediating resilience to stress and anxiety are distinct and that nicotine mediates the effects of WTS on social behavior, but not anxiety, by activating BDNF signaling. Significance statement: This study reports the positive effect of WTS and nicotine on social behavior. Furthermore, it shows the negative effects of prolonged WTS on anxiety-like behaviors and suggests that these effects are not necessarily mediated by nicotine. Finally, it identifies BDNF/TRKB signaling pathway as a major mediator of the positive effects of nicotine on social interaction. As a result, this work emphasizes the importance of considering the activation status of this signaling pathway when developing smoking cessation strategies.Published2023-01-12T10:42:18Z2023-01-12T10:42:18Z20202023-01-12Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0166-4328http://hdl.handle.net/10725/14359https://doi.org/10.1016/j.bbr.2020.112499Khalifeh, M., Hobeika, R., El Hayek, L., Saad, J., Eid, F., El-Khoury, R., ... & Sleiman, S. F. (2020). Nicotine induces resilience to chronic social defeat stress in a mouse model of water pipe tobacco exposure by activating BDNF signaling. Behavioural Brain Research, 382, 112499.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://www.sciencedirect.com/science/article/pii/S0166432819318212enBehavioural Brain Researchinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/143592023-01-12T10:50:50Z |
| spellingShingle | Nicotine induces resilience to chronic social defeat stress in a mouse model of water pipe tobacco exposure by activating BDNF signaling Khalifeh, Mohamad |
| status_str | publishedVersion |
| title | Nicotine induces resilience to chronic social defeat stress in a mouse model of water pipe tobacco exposure by activating BDNF signaling |
| title_full | Nicotine induces resilience to chronic social defeat stress in a mouse model of water pipe tobacco exposure by activating BDNF signaling |
| title_fullStr | Nicotine induces resilience to chronic social defeat stress in a mouse model of water pipe tobacco exposure by activating BDNF signaling |
| title_full_unstemmed | Nicotine induces resilience to chronic social defeat stress in a mouse model of water pipe tobacco exposure by activating BDNF signaling |
| title_short | Nicotine induces resilience to chronic social defeat stress in a mouse model of water pipe tobacco exposure by activating BDNF signaling |
| title_sort | Nicotine induces resilience to chronic social defeat stress in a mouse model of water pipe tobacco exposure by activating BDNF signaling |
| url | http://hdl.handle.net/10725/14359 https://doi.org/10.1016/j.bbr.2020.112499 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.sciencedirect.com/science/article/pii/S0166432819318212 |