Noninvasive Assessment of Coronary Flow Reserve in the Left Anterior Descending Artery by Transthoracic Echocardiography before and after Stenting
Background: Noninvasive assessment of coronary flow reserve in the left anterior descending artery (LAD) by transthoracic Doppler echocardiography (TTDE) has been already validated as a new method for determining the degree of stenosis over the proximal flow. Objectives: The aim of the study is to d...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , |
| التنسيق: | article |
| منشور في: |
2007
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/4040 http://dx.doi.org/ 10.1111/j.1540-8175.2007.00478.x http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://onlinelibrary.wiley.com/doi/10.1111/j.1540-8175.2007.00478.x/full |
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| _version_ | 1864513462832463872 |
|---|---|
| author | Ghanem, Georges |
| author2 | Chammas, Elie Dib, Chadi Rahhal, Maya Helou, Toni Tarcha, Walid |
| author2_role | author author author author author |
| author_facet | Ghanem, Georges Chammas, Elie Dib, Chadi Rahhal, Maya Helou, Toni Tarcha, Walid |
| author_role | author |
| dc.creator.none.fl_str_mv | Ghanem, Georges Chammas, Elie Dib, Chadi Rahhal, Maya Helou, Toni Tarcha, Walid |
| dc.date.none.fl_str_mv | 2007 2016-06-15T08:04:58Z 2016-06-15T08:04:58Z 2016-06-15 |
| dc.identifier.none.fl_str_mv | 0742-2822 http://hdl.handle.net/10725/4040 http://dx.doi.org/ 10.1111/j.1540-8175.2007.00478.x Chammas, E., Dib, C., Rahhal, M., Helou, T., Ghanem, G., & Tarcha, W. (2007). Noninvasive assessment of coronary flow reserve in the left anterior descending artery by transthoracic echocardiography before and after stenting. Echocardiography, 24(8), 789-794. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://onlinelibrary.wiley.com/doi/10.1111/j.1540-8175.2007.00478.x/full |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Echocardiography |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Noninvasive Assessment of Coronary Flow Reserve in the Left Anterior Descending Artery by Transthoracic Echocardiography before and after Stenting |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Background: Noninvasive assessment of coronary flow reserve in the left anterior descending artery (LAD) by transthoracic Doppler echocardiography (TTDE) has been already validated as a new method for determining the degree of stenosis over the proximal flow. Objectives: The aim of the study is to determine, by TTDE, the feasibility and the value of the coronary flow reserve (CFR) (defined as the maximal increase in coronary blood flow above its basal pressure for a given perfusion pressure when coronary circulation is maximally dilated) in the mid-to-distal LAD before and after percutaneous angioplasty and to demonstrate the early recovery of microvascular tone immediately after stenting. Methods: The study population consisted of 36 patients with significant isolated LAD stenosis (70–90%) identified by coronary angiography. CFR was recorded in the mid-to-distal LAD at rest and during hyperemia obtained after adenosine intravenous infusion before and after stenting. Results: Adequate visualization of the LAD was obtained in 25 out of 36 patients (70%). At rest the mean CFR was 1.5132 ± 0.33 (1.1–2.58). However, after stenting the mean CFR was significantly higher: 2.18 ± 0.55 (1.3–3.8), with P <0.01. Conclusions: CFR can be easily determined by TTE in approximately 70% of patients. Noninvasive Doppler echocardiography shows impaired CFR in patients with LAD disease. After stenting CFR is restored, demonstrating early recovery of microvascular tone. These results are comparable to those published in the same conditions. Larger series with a long-term follow-up may allow identifying patients at high risk for restenosis after stenting. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_87c721e2b4caf9ef5bdc4f146c33e991 |
| identifier_str_mv | 0742-2822 Chammas, E., Dib, C., Rahhal, M., Helou, T., Ghanem, G., & Tarcha, W. (2007). Noninvasive assessment of coronary flow reserve in the left anterior descending artery by transthoracic echocardiography before and after stenting. Echocardiography, 24(8), 789-794. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/4040 |
| publishDate | 2007 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Noninvasive Assessment of Coronary Flow Reserve in the Left Anterior Descending Artery by Transthoracic Echocardiography before and after StentingGhanem, GeorgesChammas, ElieDib, ChadiRahhal, MayaHelou, ToniTarcha, WalidBackground: Noninvasive assessment of coronary flow reserve in the left anterior descending artery (LAD) by transthoracic Doppler echocardiography (TTDE) has been already validated as a new method for determining the degree of stenosis over the proximal flow. Objectives: The aim of the study is to determine, by TTDE, the feasibility and the value of the coronary flow reserve (CFR) (defined as the maximal increase in coronary blood flow above its basal pressure for a given perfusion pressure when coronary circulation is maximally dilated) in the mid-to-distal LAD before and after percutaneous angioplasty and to demonstrate the early recovery of microvascular tone immediately after stenting. Methods: The study population consisted of 36 patients with significant isolated LAD stenosis (70–90%) identified by coronary angiography. CFR was recorded in the mid-to-distal LAD at rest and during hyperemia obtained after adenosine intravenous infusion before and after stenting. Results: Adequate visualization of the LAD was obtained in 25 out of 36 patients (70%). At rest the mean CFR was 1.5132 ± 0.33 (1.1–2.58). However, after stenting the mean CFR was significantly higher: 2.18 ± 0.55 (1.3–3.8), with P <0.01. Conclusions: CFR can be easily determined by TTE in approximately 70% of patients. Noninvasive Doppler echocardiography shows impaired CFR in patients with LAD disease. After stenting CFR is restored, demonstrating early recovery of microvascular tone. These results are comparable to those published in the same conditions. Larger series with a long-term follow-up may allow identifying patients at high risk for restenosis after stenting.PublishedN/A2016-06-15T08:04:58Z2016-06-15T08:04:58Z20072016-06-15Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0742-2822http://hdl.handle.net/10725/4040http://dx.doi.org/ 10.1111/j.1540-8175.2007.00478.xChammas, E., Dib, C., Rahhal, M., Helou, T., Ghanem, G., & Tarcha, W. (2007). Noninvasive assessment of coronary flow reserve in the left anterior descending artery by transthoracic echocardiography before and after stenting. Echocardiography, 24(8), 789-794.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttp://onlinelibrary.wiley.com/doi/10.1111/j.1540-8175.2007.00478.x/fullenEchocardiographyinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/40402021-03-19T10:00:52Z |
| spellingShingle | Noninvasive Assessment of Coronary Flow Reserve in the Left Anterior Descending Artery by Transthoracic Echocardiography before and after Stenting Ghanem, Georges |
| status_str | publishedVersion |
| title | Noninvasive Assessment of Coronary Flow Reserve in the Left Anterior Descending Artery by Transthoracic Echocardiography before and after Stenting |
| title_full | Noninvasive Assessment of Coronary Flow Reserve in the Left Anterior Descending Artery by Transthoracic Echocardiography before and after Stenting |
| title_fullStr | Noninvasive Assessment of Coronary Flow Reserve in the Left Anterior Descending Artery by Transthoracic Echocardiography before and after Stenting |
| title_full_unstemmed | Noninvasive Assessment of Coronary Flow Reserve in the Left Anterior Descending Artery by Transthoracic Echocardiography before and after Stenting |
| title_short | Noninvasive Assessment of Coronary Flow Reserve in the Left Anterior Descending Artery by Transthoracic Echocardiography before and after Stenting |
| title_sort | Noninvasive Assessment of Coronary Flow Reserve in the Left Anterior Descending Artery by Transthoracic Echocardiography before and after Stenting |
| url | http://hdl.handle.net/10725/4040 http://dx.doi.org/ 10.1111/j.1540-8175.2007.00478.x http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://onlinelibrary.wiley.com/doi/10.1111/j.1540-8175.2007.00478.x/full |