Sickle cell nephropathy
Sickle cell nephropathy is a major complication of sickle cell disease. It manifests in different forms, including glomerulopathy, proteinuria, hematuria, and tubular defects, and frequently results in end-stage renal disease (ESRD). Different pathophysiologic mechanisms have been proposed to explai...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , |
| التنسيق: | article |
| منشور في: |
2018
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/10756 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://link.springer.com/article/10.1007/s11255-018-1803-3 |
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| _version_ | 1864513487419473920 |
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| author | Hariri, Essa |
| author2 | Mansour, Anthony El Alam, Andrew Daaboul, Yazan Korjian, Serge Bahous, Sola Aoun |
| author2_role | author author author author author |
| author_facet | Hariri, Essa Mansour, Anthony El Alam, Andrew Daaboul, Yazan Korjian, Serge Bahous, Sola Aoun |
| author_role | author |
| dc.creator.none.fl_str_mv | Hariri, Essa Mansour, Anthony El Alam, Andrew Daaboul, Yazan Korjian, Serge Bahous, Sola Aoun |
| dc.date.none.fl_str_mv | 2018 2019-06-07T10:30:47Z 2019-06-07T10:30:47Z 2019-06-07 |
| dc.identifier.none.fl_str_mv | 1573-2584 http://hdl.handle.net/10725/10756 Hariri, E., Mansour, A., El Alam, A., Daaboul, Y., Korjian, S., & Bahous, S. A. (2018). Sickle cell nephropathy: an update on pathophysiology, diagnosis, and treatment. International urology and nephrology, 50(6), 1075-1083. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://link.springer.com/article/10.1007/s11255-018-1803-3 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | International Urology and Nephrology |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Sickle cell nephropathy an update on pathophysiology, diagnosis, and treatment |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Sickle cell nephropathy is a major complication of sickle cell disease. It manifests in different forms, including glomerulopathy, proteinuria, hematuria, and tubular defects, and frequently results in end-stage renal disease (ESRD). Different pathophysiologic mechanisms have been proposed to explain the development of nephropathy in SCD, where hemolysis and vascular occlusion are the main contributors in the manifestations of this disease. Markers of renal injury, such as proteinuria and tubular dysfunction, have been associated with outcomes among patients with sickle cell nephropathy and provide means for early detection of nephropathy and screening prior to progression to renal failure. In small-sized clinical trials, hydroxyurea has demonstrated to be effective in slowing the progression to ESRD. Dialysis and renal transplantation represent the last resort for patients with sickle cell nephropathy. Nevertheless, despite the availability of diagnostic and therapeutic strategies, sickle cell nephropathy remains a challenging and under-recognized complication for patients with sickle cell disease. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_8a6f3dd1aae229fa33a48c9f5f11e62b |
| identifier_str_mv | 1573-2584 Hariri, E., Mansour, A., El Alam, A., Daaboul, Y., Korjian, S., & Bahous, S. A. (2018). Sickle cell nephropathy: an update on pathophysiology, diagnosis, and treatment. International urology and nephrology, 50(6), 1075-1083. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/10756 |
| publishDate | 2018 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Sickle cell nephropathyan update on pathophysiology, diagnosis, and treatmentHariri, EssaMansour, AnthonyEl Alam, AndrewDaaboul, YazanKorjian, SergeBahous, Sola AounSickle cell nephropathy is a major complication of sickle cell disease. It manifests in different forms, including glomerulopathy, proteinuria, hematuria, and tubular defects, and frequently results in end-stage renal disease (ESRD). Different pathophysiologic mechanisms have been proposed to explain the development of nephropathy in SCD, where hemolysis and vascular occlusion are the main contributors in the manifestations of this disease. Markers of renal injury, such as proteinuria and tubular dysfunction, have been associated with outcomes among patients with sickle cell nephropathy and provide means for early detection of nephropathy and screening prior to progression to renal failure. In small-sized clinical trials, hydroxyurea has demonstrated to be effective in slowing the progression to ESRD. Dialysis and renal transplantation represent the last resort for patients with sickle cell nephropathy. Nevertheless, despite the availability of diagnostic and therapeutic strategies, sickle cell nephropathy remains a challenging and under-recognized complication for patients with sickle cell disease.PublishedN/A2019-06-07T10:30:47Z2019-06-07T10:30:47Z20182019-06-07Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1573-2584http://hdl.handle.net/10725/10756Hariri, E., Mansour, A., El Alam, A., Daaboul, Y., Korjian, S., & Bahous, S. A. (2018). Sickle cell nephropathy: an update on pathophysiology, diagnosis, and treatment. International urology and nephrology, 50(6), 1075-1083.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://link.springer.com/article/10.1007/s11255-018-1803-3enInternational Urology and Nephrologyinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/107562021-03-19T10:45:23Z |
| spellingShingle | Sickle cell nephropathy Hariri, Essa |
| status_str | publishedVersion |
| title | Sickle cell nephropathy |
| title_full | Sickle cell nephropathy |
| title_fullStr | Sickle cell nephropathy |
| title_full_unstemmed | Sickle cell nephropathy |
| title_short | Sickle cell nephropathy |
| title_sort | Sickle cell nephropathy |
| url | http://hdl.handle.net/10725/10756 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://link.springer.com/article/10.1007/s11255-018-1803-3 |