Bevacizumab and neovascular age related macular degeneration
The pathogenesis of neovascular age related macular degeneration (AMD) is multifactorial including inflammation and angiogenesis leading to choroidal neovascularization (CNV). Therapy against vascular endothelial growth factor (VEGF) has revolutionized the treatment of neovascular AMD. Intravitreal...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , |
| التنسيق: | article |
| منشور في: |
2011
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/14186 https://doi.org/10.3109/08820538.2010.545100 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.tandfonline.com/doi/abs/10.3109/08820538.2010.545100?journalCode=isio20 |
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| _version_ | 1864513469178445824 |
|---|---|
| author | El Mollayess, Georges |
| author2 | Noureddine, Baha' N. Bashshur, Ziad F. |
| author2_role | author author |
| author_facet | El Mollayess, Georges Noureddine, Baha' N. Bashshur, Ziad F. |
| author_role | author |
| dc.creator.none.fl_str_mv | El Mollayess, Georges Noureddine, Baha' N. Bashshur, Ziad F. |
| dc.date.none.fl_str_mv | 2011 2022-11-01T12:38:18Z 2022-11-01T12:38:18Z 2022-11-01 |
| dc.identifier.none.fl_str_mv | 0882-0538 http://hdl.handle.net/10725/14186 https://doi.org/10.3109/08820538.2010.545100 El-Mollayess, G. M., Noureddine, B. N., & Bashshur, Z. F. (2011). Bevacizumab and neovascular age related macular degeneration: pathogenesis and treatment. Seminars in Ophthalmology, 26(3), 69-76. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.tandfonline.com/doi/abs/10.3109/08820538.2010.545100?journalCode=isio20 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Seminars in Ophthalmology |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Bevacizumab and neovascular age related macular degeneration pathogenesis and treatment |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | The pathogenesis of neovascular age related macular degeneration (AMD) is multifactorial including inflammation and angiogenesis leading to choroidal neovascularization (CNV). Therapy against vascular endothelial growth factor (VEGF) has revolutionized the treatment of neovascular AMD. Intravitreal off-label use of bevacizumab proved to be safe. This literature review was conducted to study improvement in visual acuity, change in central retinal thickness (CRT), safety, pharmacodynamics, and possible resistance to intravitreal bevacizumab over a one-year period in eyes with neovascular AMD. We reviewed articles between 1997 and January 2010 that included at least 30 patients with AMD who received intravitreal bevacizumab monotherapy for at least 1 year. The mean number of letters gained, decrease in CRT, and number of injections were 8 letters, 125.3 µm, and 4.3 injections, respectively. Further, randomized prospective clinical trials are needed to determine the efficacy and safety of intravitreal bevacizumab in the treatment of neovascular AMD. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_8aa4bdf4efcb717db7b6ab03d4fbdb34 |
| identifier_str_mv | 0882-0538 El-Mollayess, G. M., Noureddine, B. N., & Bashshur, Z. F. (2011). Bevacizumab and neovascular age related macular degeneration: pathogenesis and treatment. Seminars in Ophthalmology, 26(3), 69-76. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/14186 |
| publishDate | 2011 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Bevacizumab and neovascular age related macular degenerationpathogenesis and treatmentEl Mollayess, GeorgesNoureddine, Baha' N.Bashshur, Ziad F.The pathogenesis of neovascular age related macular degeneration (AMD) is multifactorial including inflammation and angiogenesis leading to choroidal neovascularization (CNV). Therapy against vascular endothelial growth factor (VEGF) has revolutionized the treatment of neovascular AMD. Intravitreal off-label use of bevacizumab proved to be safe. This literature review was conducted to study improvement in visual acuity, change in central retinal thickness (CRT), safety, pharmacodynamics, and possible resistance to intravitreal bevacizumab over a one-year period in eyes with neovascular AMD. We reviewed articles between 1997 and January 2010 that included at least 30 patients with AMD who received intravitreal bevacizumab monotherapy for at least 1 year. The mean number of letters gained, decrease in CRT, and number of injections were 8 letters, 125.3 µm, and 4.3 injections, respectively. Further, randomized prospective clinical trials are needed to determine the efficacy and safety of intravitreal bevacizumab in the treatment of neovascular AMD.Published2022-11-01T12:38:18Z2022-11-01T12:38:18Z20112022-11-01Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0882-0538http://hdl.handle.net/10725/14186https://doi.org/10.3109/08820538.2010.545100El-Mollayess, G. M., Noureddine, B. N., & Bashshur, Z. F. (2011). Bevacizumab and neovascular age related macular degeneration: pathogenesis and treatment. Seminars in Ophthalmology, 26(3), 69-76.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://www.tandfonline.com/doi/abs/10.3109/08820538.2010.545100?journalCode=isio20enSeminars in Ophthalmologyinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/141862022-11-01T12:38:55Z |
| spellingShingle | Bevacizumab and neovascular age related macular degeneration El Mollayess, Georges |
| status_str | publishedVersion |
| title | Bevacizumab and neovascular age related macular degeneration |
| title_full | Bevacizumab and neovascular age related macular degeneration |
| title_fullStr | Bevacizumab and neovascular age related macular degeneration |
| title_full_unstemmed | Bevacizumab and neovascular age related macular degeneration |
| title_short | Bevacizumab and neovascular age related macular degeneration |
| title_sort | Bevacizumab and neovascular age related macular degeneration |
| url | http://hdl.handle.net/10725/14186 https://doi.org/10.3109/08820538.2010.545100 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.tandfonline.com/doi/abs/10.3109/08820538.2010.545100?journalCode=isio20 |