Beyond the Milan criteria
Background To date the selection of the best candidates for liver transplantation (LT) owing to hepatocellular carcinoma (HCC) has been mainly based on tumor morphological characteristics (nodule diameter and number), which have resulted to be independent risk factors for short long-term survival an...
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2012
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| Online Access: | http://hdl.handle.net/10725/10777 https://doi.org/10.1097/MCG.0b013e31822b36f6 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://europepmc.org/article/med/21897282 |
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| _version_ | 1864513487437299712 |
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| author | De Carlis, Luciano |
| author2 | Di Sandro, Stefano Giacomoni, Alessandro Slim, Abdallah Lauterio, Andrea Mangoni, Iacopo Mihaylov, Plamen Pirotta, Vincenzo Aseni, Paolo Rampoldi, Antonio |
| author2_role | author author author author author author author author author |
| author_facet | De Carlis, Luciano Di Sandro, Stefano Giacomoni, Alessandro Slim, Abdallah Lauterio, Andrea Mangoni, Iacopo Mihaylov, Plamen Pirotta, Vincenzo Aseni, Paolo Rampoldi, Antonio |
| author_role | author |
| dc.creator.none.fl_str_mv | De Carlis, Luciano Di Sandro, Stefano Giacomoni, Alessandro Slim, Abdallah Lauterio, Andrea Mangoni, Iacopo Mihaylov, Plamen Pirotta, Vincenzo Aseni, Paolo Rampoldi, Antonio |
| dc.date.none.fl_str_mv | 2012 2019-06-11T11:07:20Z 2019-06-11T11:07:20Z 2019-06-11 |
| dc.identifier.none.fl_str_mv | 1539-2031 http://hdl.handle.net/10725/10777 https://doi.org/10.1097/MCG.0b013e31822b36f6 De Carlis, L., Di Sandro, S., Giacomoni, A., Slim, A., Lauterio, A., Mangoni, I., ... & Rampoldi, A. (2012). Beyond the Milan criteria: what risks for patients with hepatocellular carcinoma progression before liver transplantation?. Journal of clinical gastroenterology, 46(1), 78-86. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://europepmc.org/article/med/21897282 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Journal of Clinical Gastroenterology |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Beyond the Milan criteria what risks for patients with hepatocellular carcinoma progression before liver transplantation? |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Background To date the selection of the best candidates for liver transplantation (LT) owing to hepatocellular carcinoma (HCC) has been mainly based on tumor morphological characteristics (nodule diameter and number), which have resulted to be independent risk factors for short long-term survival and a high rate of tumor recurrence. Methods The study cohort included 118 patients among the 166 with HCC transplanted at our unit from January 2000 to December 2007. Patients were classified according to response to locoregional treatments before LT: progressive Group A; complete Group B; partial Group C; stable Group D. Results The 3-year and 5-year overall survival rates were 65.5% and 48.9% for Group A versus 84.8% and 74.6% for Group BCD (P = 0.01). The 3-year and 5-year disease-free survival rates were 74% and 74% for Group A and 95.7% and 93% for Group BCD (P = 0.007). HCC progression was the only independent risk factor according to Cox regression P = 0.014--odds ratio 4.4 (1.35-14.3). Conclusion After aggressive HCC treatment before LT, imaging progression while on the waiting list was a strong predictor of high HCC recurrence rate also in patients who met the Milan criteria. Lack of imaging progression can contribute toward the selection of good transplant candidates for HCC together with the Milan criteria. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_8ae4cebe86b18bc925a5afd6d2f5f65b |
| identifier_str_mv | 1539-2031 De Carlis, L., Di Sandro, S., Giacomoni, A., Slim, A., Lauterio, A., Mangoni, I., ... & Rampoldi, A. (2012). Beyond the Milan criteria: what risks for patients with hepatocellular carcinoma progression before liver transplantation?. Journal of clinical gastroenterology, 46(1), 78-86. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/10777 |
| publishDate | 2012 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Beyond the Milan criteriawhat risks for patients with hepatocellular carcinoma progression before liver transplantation?De Carlis, LucianoDi Sandro, StefanoGiacomoni, AlessandroSlim, AbdallahLauterio, AndreaMangoni, IacopoMihaylov, PlamenPirotta, VincenzoAseni, PaoloRampoldi, AntonioBackground To date the selection of the best candidates for liver transplantation (LT) owing to hepatocellular carcinoma (HCC) has been mainly based on tumor morphological characteristics (nodule diameter and number), which have resulted to be independent risk factors for short long-term survival and a high rate of tumor recurrence. Methods The study cohort included 118 patients among the 166 with HCC transplanted at our unit from January 2000 to December 2007. Patients were classified according to response to locoregional treatments before LT: progressive Group A; complete Group B; partial Group C; stable Group D. Results The 3-year and 5-year overall survival rates were 65.5% and 48.9% for Group A versus 84.8% and 74.6% for Group BCD (P = 0.01). The 3-year and 5-year disease-free survival rates were 74% and 74% for Group A and 95.7% and 93% for Group BCD (P = 0.007). HCC progression was the only independent risk factor according to Cox regression P = 0.014--odds ratio 4.4 (1.35-14.3). Conclusion After aggressive HCC treatment before LT, imaging progression while on the waiting list was a strong predictor of high HCC recurrence rate also in patients who met the Milan criteria. Lack of imaging progression can contribute toward the selection of good transplant candidates for HCC together with the Milan criteria.PublishedN/A2019-06-11T11:07:20Z2019-06-11T11:07:20Z20122019-06-11Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1539-2031http://hdl.handle.net/10725/10777https://doi.org/10.1097/MCG.0b013e31822b36f6De Carlis, L., Di Sandro, S., Giacomoni, A., Slim, A., Lauterio, A., Mangoni, I., ... & Rampoldi, A. (2012). Beyond the Milan criteria: what risks for patients with hepatocellular carcinoma progression before liver transplantation?. Journal of clinical gastroenterology, 46(1), 78-86.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://europepmc.org/article/med/21897282enJournal of Clinical Gastroenterologyinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/107772022-10-07T13:27:19Z |
| spellingShingle | Beyond the Milan criteria De Carlis, Luciano |
| status_str | publishedVersion |
| title | Beyond the Milan criteria |
| title_full | Beyond the Milan criteria |
| title_fullStr | Beyond the Milan criteria |
| title_full_unstemmed | Beyond the Milan criteria |
| title_short | Beyond the Milan criteria |
| title_sort | Beyond the Milan criteria |
| url | http://hdl.handle.net/10725/10777 https://doi.org/10.1097/MCG.0b013e31822b36f6 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://europepmc.org/article/med/21897282 |