Lactic acid mediates resistance to stress through class I HDAC induction in a chronic social defeat model of depression. (c2017)
Depression is one of the most common psychiatric disorders and a leading cause of disability worldwide. Environmental factors, mainly stress, play an important role in promoting this disorder by inducing changes in gene expression that are sustained by epigenetic modifications, particularly in the h...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| التنسيق: | masterThesis |
| منشور في: |
2017
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/8181 https://doi.org/10.26756/th.2018.59 http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513467089682432 |
|---|---|
| author | Ghandour, Rim Mohamad El |
| author_facet | Ghandour, Rim Mohamad El |
| author_role | author |
| dc.creator.none.fl_str_mv | Ghandour, Rim Mohamad El |
| dc.date.none.fl_str_mv | 2017 2017-12-01 2018-07-10T08:07:49Z 2018-07-10T08:07:49Z 2018-07-10 |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10725/8181 https://doi.org/10.26756/th.2018.59 http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Lebanese American University |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Lebanese American University -- Dissertations Dissertations, Academic Lactates Exercise -- Physiological aspects Stress management Depression, Mental -- Alternative treatment Brain -- Metabolism |
| dc.title.none.fl_str_mv | Lactic acid mediates resistance to stress through class I HDAC induction in a chronic social defeat model of depression. (c2017) |
| dc.type.none.fl_str_mv | Thesis info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/masterThesis |
| description | Depression is one of the most common psychiatric disorders and a leading cause of disability worldwide. Environmental factors, mainly stress, play an important role in promoting this disorder by inducing changes in gene expression that are sustained by epigenetic modifications, particularly in the hippocampal brain regions. Transcriptional profiling of the hippocampus revealed a downregulation in the Brain- Derived Neurotrophic Factor (Bdnf) gene expression in animal models of stress, and this downregulation was reversed by antidepressant treatment and physical exercise. In our study, we use a chronic social defeat paradigm, a validated model of depression in mice, to study the antidepressant effect of the endogenous molecule lactate that is released after physical exercise. We used multiple behavioral tests including open field, T-maze and social interaction tests to show that lactate rescues depression phenotypes such as defeat and anxiety behavior We also report that lactate activates independent pathways to affect two separate processes: promotion of resilience to stress and protection from depression. Our results reveal an antidepressant-like activity of an endogenous molecule lactate, produced after physical exercise and known to accumulate in the hippocampal regions of the brain and illustrate a novel mechanism that can explain the positive effects of exercise on mood disorders. |
| eu_rights_str_mv | openAccess |
| format | masterThesis |
| id | LAURepo_8c2668b011791b03f43cc2eede3f2e3b |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/8181 |
| publishDate | 2017 |
| publisher.none.fl_str_mv | Lebanese American University |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Lactic acid mediates resistance to stress through class I HDAC induction in a chronic social defeat model of depression. (c2017)Ghandour, Rim Mohamad ElLebanese American University -- DissertationsDissertations, AcademicLactatesExercise -- Physiological aspectsStress managementDepression, Mental -- Alternative treatmentBrain -- MetabolismDepression is one of the most common psychiatric disorders and a leading cause of disability worldwide. Environmental factors, mainly stress, play an important role in promoting this disorder by inducing changes in gene expression that are sustained by epigenetic modifications, particularly in the hippocampal brain regions. Transcriptional profiling of the hippocampus revealed a downregulation in the Brain- Derived Neurotrophic Factor (Bdnf) gene expression in animal models of stress, and this downregulation was reversed by antidepressant treatment and physical exercise. In our study, we use a chronic social defeat paradigm, a validated model of depression in mice, to study the antidepressant effect of the endogenous molecule lactate that is released after physical exercise. We used multiple behavioral tests including open field, T-maze and social interaction tests to show that lactate rescues depression phenotypes such as defeat and anxiety behavior We also report that lactate activates independent pathways to affect two separate processes: promotion of resilience to stress and protection from depression. Our results reveal an antidepressant-like activity of an endogenous molecule lactate, produced after physical exercise and known to accumulate in the hippocampal regions of the brain and illustrate a novel mechanism that can explain the positive effects of exercise on mood disorders.N/A1 hard copy: xii, 57 leaves; col. ill.; 30 cm. available at RNL.Bibliography : leaves 42-57.Lebanese American University2018-07-10T08:07:49Z2018-07-10T08:07:49Z20172018-07-102017-12-01Thesisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesishttp://hdl.handle.net/10725/8181https://doi.org/10.26756/th.2018.59http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.phpeninfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/81812021-03-19T10:43:15Z |
| spellingShingle | Lactic acid mediates resistance to stress through class I HDAC induction in a chronic social defeat model of depression. (c2017) Ghandour, Rim Mohamad El Lebanese American University -- Dissertations Dissertations, Academic Lactates Exercise -- Physiological aspects Stress management Depression, Mental -- Alternative treatment Brain -- Metabolism |
| status_str | publishedVersion |
| title | Lactic acid mediates resistance to stress through class I HDAC induction in a chronic social defeat model of depression. (c2017) |
| title_full | Lactic acid mediates resistance to stress through class I HDAC induction in a chronic social defeat model of depression. (c2017) |
| title_fullStr | Lactic acid mediates resistance to stress through class I HDAC induction in a chronic social defeat model of depression. (c2017) |
| title_full_unstemmed | Lactic acid mediates resistance to stress through class I HDAC induction in a chronic social defeat model of depression. (c2017) |
| title_short | Lactic acid mediates resistance to stress through class I HDAC induction in a chronic social defeat model of depression. (c2017) |
| title_sort | Lactic acid mediates resistance to stress through class I HDAC induction in a chronic social defeat model of depression. (c2017) |
| topic | Lebanese American University -- Dissertations Dissertations, Academic Lactates Exercise -- Physiological aspects Stress management Depression, Mental -- Alternative treatment Brain -- Metabolism |
| url | http://hdl.handle.net/10725/8181 https://doi.org/10.26756/th.2018.59 http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php |