Cytotoxicity of Anthrax Lethal Toxin to Human Acute Myeloid Leukemia Cells Is Nonapoptotic and Dependent on Extracellular Signal-Regulated Kinase 1/2 Activity
In this study, we attempt to target the mitogen-activated protein kinase (MAPK) pathway in acute myeloid leukemia (AML) cells using a recombinant anthrax lethal toxin (LeTx). LeTx consists of protective antigen (PrAg) and lethal factor (LF). PrAg binds cells, is cleaved by furin, oligomerizes, binds...
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| Other Authors: | , , , , , |
| Format: | article |
| Published: |
2013
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| Online Access: | http://hdl.handle.net/10725/2742 http://dx.doi.org/10.1593/tlo.12313 http://www.sciencedirect.com/science/article/pii/S1936523313800393 |
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