Prevalence of hepatitis C virus isolate genotypes from chronically infected Lebanese patients
To assess percentages of hepatitis C virus (HCV) genotypes in infected Lebanese patients referred to St. George Hospital, Beirut, Lebanon, 77 infected cases were studied. Of those, 27 were hemodialysis patients. Genotyping was performed by nested PCR of the HCV core-region with specific primers, fol...
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| Format: | article |
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2003
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| Online Access: | http://hdl.handle.net/10725/5231 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://europepmc.org/abstract/med/15707071 |
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| _version_ | 1864513465732825088 |
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| author | Mokhbat, J. |
| author2 | Irani-Hakime, N. Samaha, H. Almawi, W. Abou Jaoude, M. Daccache, J. Rahal, E. |
| author2_role | author author author author author author |
| author_facet | Mokhbat, J. Irani-Hakime, N. Samaha, H. Almawi, W. Abou Jaoude, M. Daccache, J. Rahal, E. |
| author_role | author |
| dc.creator.none.fl_str_mv | Mokhbat, J. Irani-Hakime, N. Samaha, H. Almawi, W. Abou Jaoude, M. Daccache, J. Rahal, E. |
| dc.date.none.fl_str_mv | 2003 2017-02-15T14:08:21Z 2017-02-15T14:08:21Z 2017-02-15 |
| dc.identifier.none.fl_str_mv | 0023-9852 http://hdl.handle.net/10725/5231 Irani-Hakime, N., Samaha, H., Almawi, W., Nasr, E., Mokhbat, J., Abou, J. M., ... & Rahal, E. (2002). Prevalence of hepatitis C virus isolate genotypes from chronically infected Lebanese patients: a hospital-based study. Le Journal medical libanais. The Lebanese medical journal, 51(3), 121-126. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://europepmc.org/abstract/med/15707071 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Lebanese Medical Journal |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Prevalence of hepatitis C virus isolate genotypes from chronically infected Lebanese patients a hospital-based study |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | To assess percentages of hepatitis C virus (HCV) genotypes in infected Lebanese patients referred to St. George Hospital, Beirut, Lebanon, 77 infected cases were studied. Of those, 27 were hemodialysis patients. Genotyping was performed by nested PCR of the HCV core-region with specific primers, followed by DNA enzyme-immunoassay using HCV type and subtype-specific probes. Single genotype infections were detected in 52 patients (67.5%). In these cases, types 1, 2, 3 and 4 were detected in 19.5%, 32.5%, 5.1% and 10.4% of the cases respectively. Twenty-five (32.5%) samples showed mixed genotype infections. Single genotype distribution was significantly different among dialysis and non-dialysis patients. In the dialysis group, genotype 2 was predominant (80%, p < 0.001). In single HCV genotype-infected patients, subtype 1b was frequently detected in nondialysis cases (34.4%) whereas this genotype was found in only 5% of dialysis cases. Genotypes 5 and 6 were not detected in any of the cases studied. This pilot hospital-based study provides evidence for the diversity of HCV genotypes in the Lebanese population and establishes differences in distribution depending on the risk group. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_98cdaef298b6d6769e5c406d6b52b430 |
| identifier_str_mv | 0023-9852 Irani-Hakime, N., Samaha, H., Almawi, W., Nasr, E., Mokhbat, J., Abou, J. M., ... & Rahal, E. (2002). Prevalence of hepatitis C virus isolate genotypes from chronically infected Lebanese patients: a hospital-based study. Le Journal medical libanais. The Lebanese medical journal, 51(3), 121-126. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/5231 |
| publishDate | 2003 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Prevalence of hepatitis C virus isolate genotypes from chronically infected Lebanese patientsa hospital-based studyMokhbat, J.Irani-Hakime, N.Samaha, H.Almawi, W.Abou Jaoude, M.Daccache, J.Rahal, E.To assess percentages of hepatitis C virus (HCV) genotypes in infected Lebanese patients referred to St. George Hospital, Beirut, Lebanon, 77 infected cases were studied. Of those, 27 were hemodialysis patients. Genotyping was performed by nested PCR of the HCV core-region with specific primers, followed by DNA enzyme-immunoassay using HCV type and subtype-specific probes. Single genotype infections were detected in 52 patients (67.5%). In these cases, types 1, 2, 3 and 4 were detected in 19.5%, 32.5%, 5.1% and 10.4% of the cases respectively. Twenty-five (32.5%) samples showed mixed genotype infections. Single genotype distribution was significantly different among dialysis and non-dialysis patients. In the dialysis group, genotype 2 was predominant (80%, p < 0.001). In single HCV genotype-infected patients, subtype 1b was frequently detected in nondialysis cases (34.4%) whereas this genotype was found in only 5% of dialysis cases. Genotypes 5 and 6 were not detected in any of the cases studied. This pilot hospital-based study provides evidence for the diversity of HCV genotypes in the Lebanese population and establishes differences in distribution depending on the risk group.PublishedN/A2017-02-15T14:08:21Z2017-02-15T14:08:21Z20032017-02-15Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0023-9852http://hdl.handle.net/10725/5231Irani-Hakime, N., Samaha, H., Almawi, W., Nasr, E., Mokhbat, J., Abou, J. M., ... & Rahal, E. (2002). Prevalence of hepatitis C virus isolate genotypes from chronically infected Lebanese patients: a hospital-based study. Le Journal medical libanais. The Lebanese medical journal, 51(3), 121-126.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttp://europepmc.org/abstract/med/15707071enLebanese Medical Journalinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/52312021-03-19T10:00:48Z |
| spellingShingle | Prevalence of hepatitis C virus isolate genotypes from chronically infected Lebanese patients Mokhbat, J. |
| status_str | publishedVersion |
| title | Prevalence of hepatitis C virus isolate genotypes from chronically infected Lebanese patients |
| title_full | Prevalence of hepatitis C virus isolate genotypes from chronically infected Lebanese patients |
| title_fullStr | Prevalence of hepatitis C virus isolate genotypes from chronically infected Lebanese patients |
| title_full_unstemmed | Prevalence of hepatitis C virus isolate genotypes from chronically infected Lebanese patients |
| title_short | Prevalence of hepatitis C virus isolate genotypes from chronically infected Lebanese patients |
| title_sort | Prevalence of hepatitis C virus isolate genotypes from chronically infected Lebanese patients |
| url | http://hdl.handle.net/10725/5231 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://europepmc.org/abstract/med/15707071 |