A catalytic asymmetric synthesis of 5,5-dimethylproline
The methyl ester derivative of commercially available N-acetyl-allylglycine readily undergoes cross-metathesis with 2-methylbut-2-ene and ruthenium–alkylidene catalyst to afford the prenylglycine derivative. Acid-catalysed cyclisation then affords 5,5-dimethylproline in near quantitative yield and e...
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| Format: | article |
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2005
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| Online Access: | http://hdl.handle.net/10725/2869 http://dx.doi.org/10.1016/j.tetasy.2005.05.003 http://www.sciencedirect.com/science/article/pii/S0957416605003411 |
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