Novel platinum(II)-based anticancer complexes and molecular hosts as their drug delivery vehicles
Platinum(II)-based DNA intercalators where the intercalating ligand is 1,10-phenanthroline or a phenanthroline derivative and where the ancillary ligand is either achiral (e.g. ethylenediamine) or chiral (e.g. diaminocyclohexane) show a range of cytotoxicities with a defined structure–activity relat...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , |
| التنسيق: | article |
| منشور في: |
2007
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/3494 http://dx.doi.org/10.1039/b704973k http://pubs.rsc.org/en/content/articlehtml/2007/dt/b704973k |
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| _version_ | 1864513461329854464 |
|---|---|
| author | Taleb, Robin I. |
| author2 | Wheate, Nial J. Krause-Heuer, Anwen M. Cook, Rebekah L. Wang, Shaoyu Higgins, Vincent J. Aldrich-Wright, Janice R. |
| author2_role | author author author author author author |
| author_facet | Taleb, Robin I. Wheate, Nial J. Krause-Heuer, Anwen M. Cook, Rebekah L. Wang, Shaoyu Higgins, Vincent J. Aldrich-Wright, Janice R. |
| author_role | author |
| dc.creator.none.fl_str_mv | Taleb, Robin I. Wheate, Nial J. Krause-Heuer, Anwen M. Cook, Rebekah L. Wang, Shaoyu Higgins, Vincent J. Aldrich-Wright, Janice R. |
| dc.date.none.fl_str_mv | 2007 2016-04-06T05:47:11Z 2016-04-06T05:47:11Z 2016-04-06 |
| dc.identifier.none.fl_str_mv | 1477-9226 http://hdl.handle.net/10725/3494 http://dx.doi.org/10.1039/b704973k Wheate, N. J., Taleb, R. I., Krause-Heuer, A. M., Cook, R. L., Wang, S., Higgins, V. J., & Aldrich-Wright, J. R. (2007). Novel platinum (II)-based anticancer complexes and molecular hosts as their drug delivery vehicles. Dalton Transactions, (43), 5055-5064. http://pubs.rsc.org/en/content/articlehtml/2007/dt/b704973k |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Dalton Transactions |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Novel platinum(II)-based anticancer complexes and molecular hosts as their drug delivery vehicles |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Platinum(II)-based DNA intercalators where the intercalating ligand is 1,10-phenanthroline or a phenanthroline derivative and where the ancillary ligand is either achiral (e.g. ethylenediamine) or chiral (e.g. diaminocyclohexane) show a range of cytotoxicities with a defined structure–activity relationship. The most cytotoxic are those that contain methylated-phenanthroline ligands and 1S,2S-diaminocyclohexane (S,S-dach) as the ancillary ligand. We have developed a new purification method using Sep-Pak R C-18 reverse phase columns, which means these metal complexes can be made faster and cheaper compared to published methods. Platinum(II)-based complexes containing imidazole, pyrrole and b-alanine subunits, that are capable of recognising specific DNA base-pair sequences have also been synthesised. These include linear or hairpin polyamide ligands that can recognise DNA sequences up to seven base-pairs in length and contain single platinum centres capable of forming monofunctional adducts with DNA. We have now synthesised and characterised, by 1 H and 195Pt NMR, ESI-MS and elemental analysis, the first dinuclear platinum(II) DNA sequence selective agent. Finally, using 1 H NMR we have examined the encapsulation of our platinum(II)-based DNA intercalators by cucurbit[6]uril (CB[6]). Encapsulation by CB[6] was found to not significantly change the cytotoxicity of five platinum(II)-based DNA intercalators, indicating it may have utility as a molecular carrier for improved drug delivery. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_9bc41697ffac7aebcded83e9bdd3462a |
| identifier_str_mv | 1477-9226 Wheate, N. J., Taleb, R. I., Krause-Heuer, A. M., Cook, R. L., Wang, S., Higgins, V. J., & Aldrich-Wright, J. R. (2007). Novel platinum (II)-based anticancer complexes and molecular hosts as their drug delivery vehicles. Dalton Transactions, (43), 5055-5064. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/3494 |
| publishDate | 2007 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Novel platinum(II)-based anticancer complexes and molecular hosts as their drug delivery vehiclesTaleb, Robin I.Wheate, Nial J.Krause-Heuer, Anwen M.Cook, Rebekah L.Wang, ShaoyuHiggins, Vincent J.Aldrich-Wright, Janice R.Platinum(II)-based DNA intercalators where the intercalating ligand is 1,10-phenanthroline or a phenanthroline derivative and where the ancillary ligand is either achiral (e.g. ethylenediamine) or chiral (e.g. diaminocyclohexane) show a range of cytotoxicities with a defined structure–activity relationship. The most cytotoxic are those that contain methylated-phenanthroline ligands and 1S,2S-diaminocyclohexane (S,S-dach) as the ancillary ligand. We have developed a new purification method using Sep-Pak R C-18 reverse phase columns, which means these metal complexes can be made faster and cheaper compared to published methods. Platinum(II)-based complexes containing imidazole, pyrrole and b-alanine subunits, that are capable of recognising specific DNA base-pair sequences have also been synthesised. These include linear or hairpin polyamide ligands that can recognise DNA sequences up to seven base-pairs in length and contain single platinum centres capable of forming monofunctional adducts with DNA. We have now synthesised and characterised, by 1 H and 195Pt NMR, ESI-MS and elemental analysis, the first dinuclear platinum(II) DNA sequence selective agent. Finally, using 1 H NMR we have examined the encapsulation of our platinum(II)-based DNA intercalators by cucurbit[6]uril (CB[6]). Encapsulation by CB[6] was found to not significantly change the cytotoxicity of five platinum(II)-based DNA intercalators, indicating it may have utility as a molecular carrier for improved drug delivery.PublishedN/A2016-04-06T05:47:11Z2016-04-06T05:47:11Z20072016-04-06Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1477-9226http://hdl.handle.net/10725/3494http://dx.doi.org/10.1039/b704973kWheate, N. J., Taleb, R. I., Krause-Heuer, A. M., Cook, R. L., Wang, S., Higgins, V. J., & Aldrich-Wright, J. R. (2007). Novel platinum (II)-based anticancer complexes and molecular hosts as their drug delivery vehicles. Dalton Transactions, (43), 5055-5064.http://pubs.rsc.org/en/content/articlehtml/2007/dt/b704973kenDalton Transactionsinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/34942020-05-26T08:35:10Z |
| spellingShingle | Novel platinum(II)-based anticancer complexes and molecular hosts as their drug delivery vehicles Taleb, Robin I. |
| status_str | publishedVersion |
| title | Novel platinum(II)-based anticancer complexes and molecular hosts as their drug delivery vehicles |
| title_full | Novel platinum(II)-based anticancer complexes and molecular hosts as their drug delivery vehicles |
| title_fullStr | Novel platinum(II)-based anticancer complexes and molecular hosts as their drug delivery vehicles |
| title_full_unstemmed | Novel platinum(II)-based anticancer complexes and molecular hosts as their drug delivery vehicles |
| title_short | Novel platinum(II)-based anticancer complexes and molecular hosts as their drug delivery vehicles |
| title_sort | Novel platinum(II)-based anticancer complexes and molecular hosts as their drug delivery vehicles |
| url | http://hdl.handle.net/10725/3494 http://dx.doi.org/10.1039/b704973k http://pubs.rsc.org/en/content/articlehtml/2007/dt/b704973k |