Heat Shock Protein 60 in Hepatocellular Carcinoma
Heat shock protein 60 (HSP60) is a mitochondrial chaperone that is implicated in physiological and pathological processes. For instance, it contributes to protein folding and stability, translocation of mitochondrial proteins, and apoptosis. Variations in the expression levels of HSP60 have been cor...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , |
| التنسيق: | article |
| منشور في: |
2020
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/12015 https://doi.org/10.3389/fmolb.2020.00060 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.frontiersin.org/articles/10.3389/fmolb.2020.00060/full |
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| _version_ | 1864513489679155200 |
|---|---|
| author | Hoter, Abdullah |
| author2 | Rizk, Sandra Naim, Hassan Y. |
| author2_role | author author |
| author_facet | Hoter, Abdullah Rizk, Sandra Naim, Hassan Y. |
| author_role | author |
| dc.creator.none.fl_str_mv | Hoter, Abdullah Rizk, Sandra Naim, Hassan Y. |
| dc.date.none.fl_str_mv | 2020-07-22T11:15:06Z 2020-07-22T11:15:06Z 2020 2020-07-22 |
| dc.identifier.none.fl_str_mv | 2296-889X http://hdl.handle.net/10725/12015 https://doi.org/10.3389/fmolb.2020.00060 Hoter, A., Rizk, S., & Naim, H. Y. (2020). Heat Shock Protein 60 in Hepatocellular Carcinoma: Insights and Perspectives. Frontiers in Molecular Biosciences, 7, 1-9. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.frontiersin.org/articles/10.3389/fmolb.2020.00060/full |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Frontiers in Molecular Biosciences |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Heat Shock Protein 60 in Hepatocellular Carcinoma Insights and Perspectives |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Heat shock protein 60 (HSP60) is a mitochondrial chaperone that is implicated in physiological and pathological processes. For instance, it contributes to protein folding and stability, translocation of mitochondrial proteins, and apoptosis. Variations in the expression levels of HSP60 have been correlated to various diseases and cancers, including hepatocellular carcinoma (HCC). Unlike other HSPs which clearly increase in some cancers, data about HSP60 levels in HCC are controversial and difficult to interpret. In the current review, we summarize and simplify the current knowledge about the role of HSP60 in HCC. In addition, we highlight the possibility of its targeting, using chemical compounds and/or genetic tools for treatment of HCC. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_9d107bbce2be21eac5a5baca0b4d9bfc |
| identifier_str_mv | 2296-889X Hoter, A., Rizk, S., & Naim, H. Y. (2020). Heat Shock Protein 60 in Hepatocellular Carcinoma: Insights and Perspectives. Frontiers in Molecular Biosciences, 7, 1-9. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/12015 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Heat Shock Protein 60 in Hepatocellular CarcinomaInsights and PerspectivesHoter, AbdullahRizk, SandraNaim, Hassan Y.Heat shock protein 60 (HSP60) is a mitochondrial chaperone that is implicated in physiological and pathological processes. For instance, it contributes to protein folding and stability, translocation of mitochondrial proteins, and apoptosis. Variations in the expression levels of HSP60 have been correlated to various diseases and cancers, including hepatocellular carcinoma (HCC). Unlike other HSPs which clearly increase in some cancers, data about HSP60 levels in HCC are controversial and difficult to interpret. In the current review, we summarize and simplify the current knowledge about the role of HSP60 in HCC. In addition, we highlight the possibility of its targeting, using chemical compounds and/or genetic tools for treatment of HCC.PublishedN/A2020-07-22T11:15:06Z2020-07-22T11:15:06Z20202020-07-22Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2296-889Xhttp://hdl.handle.net/10725/12015https://doi.org/10.3389/fmolb.2020.00060Hoter, A., Rizk, S., & Naim, H. Y. (2020). Heat Shock Protein 60 in Hepatocellular Carcinoma: Insights and Perspectives. Frontiers in Molecular Biosciences, 7, 1-9.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://www.frontiersin.org/articles/10.3389/fmolb.2020.00060/fullenFrontiers in Molecular Biosciencesinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/120152021-03-19T10:47:40Z |
| spellingShingle | Heat Shock Protein 60 in Hepatocellular Carcinoma Hoter, Abdullah |
| status_str | publishedVersion |
| title | Heat Shock Protein 60 in Hepatocellular Carcinoma |
| title_full | Heat Shock Protein 60 in Hepatocellular Carcinoma |
| title_fullStr | Heat Shock Protein 60 in Hepatocellular Carcinoma |
| title_full_unstemmed | Heat Shock Protein 60 in Hepatocellular Carcinoma |
| title_short | Heat Shock Protein 60 in Hepatocellular Carcinoma |
| title_sort | Heat Shock Protein 60 in Hepatocellular Carcinoma |
| url | http://hdl.handle.net/10725/12015 https://doi.org/10.3389/fmolb.2020.00060 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.frontiersin.org/articles/10.3389/fmolb.2020.00060/full |