T-cell-derived interleukin-17 regulates the level and stability of cyclooxygenase-2 (COX-2) mRNA through restricted activation of the p38 mitogen-activated protein kinase cascade
Although interleukin-17 (IL-17) is the pre-eminent T-cell-derived pro-inflammatory cytokine, its cellular mechanism of action remains poorly understood. We explored novel signaling pathways mediating IL-17 induction of the cyclooxygenase-2 (COX-2) gene in human chondrocytes, synovial fibroblasts, an...
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| Other Authors: | , , |
| Format: | article |
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2003
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| Online Access: | http://hdl.handle.net/10725/2312 http://dx.doi.org/10.1074/jbc.M212790200 http://www.jbc.org/content/278/29/26897.short |
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