T-cell-derived interleukin-17 regulates the level and stability of cyclooxygenase-2 (COX-2) mRNA through restricted activation of the p38 mitogen-activated protein kinase cascade
Although interleukin-17 (IL-17) is the pre-eminent T-cell-derived pro-inflammatory cytokine, its cellular mechanism of action remains poorly understood. We explored novel signaling pathways mediating IL-17 induction of the cyclooxygenase-2 (COX-2) gene in human chondrocytes, synovial fibroblasts, an...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | , , |
| Format: | article |
| Published: |
2003
|
| Online Access: | http://hdl.handle.net/10725/2312 http://dx.doi.org/10.1074/jbc.M212790200 http://www.jbc.org/content/278/29/26897.short |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Be the first to leave a comment!