Palladin is a Selective Regulator of Rho GTPases During Cancer Cell Migration
Glioblastoma multiforme (GBM) is a highly aggressive and infiltrative brain tumor that carries a poor prognosis and mostly originates from normal astrocytic glial cells. The dissemination of this rapidly proliferating neoplasm into neighboring regions of the brain is highly reliant on cell migration...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| التنسيق: | masterThesis |
| منشور في: |
2023
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/15138 https://doi.org/10.26756/th.2023.623 http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513470050861056 |
|---|---|
| author | El Jaafari, Nour |
| author_facet | El Jaafari, Nour |
| author_role | author |
| dc.creator.none.fl_str_mv | El Jaafari, Nour |
| dc.date.none.fl_str_mv | 2023-10-24T09:58:35Z 2023-10-24T09:58:35Z 2023 2023-04-28 |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10725/15138 https://doi.org/10.26756/th.2023.623 http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Lebanese American University |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Glioblastoma multiforme Cancer cells -- Motility Cell migration Rho GTPases Lebanese American University -- Dissertations Dissertations, Academic |
| dc.title.none.fl_str_mv | Palladin is a Selective Regulator of Rho GTPases During Cancer Cell Migration |
| dc.type.none.fl_str_mv | Thesis info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/masterThesis |
| description | Glioblastoma multiforme (GBM) is a highly aggressive and infiltrative brain tumor that carries a poor prognosis and mostly originates from normal astrocytic glial cells. The dissemination of this rapidly proliferating neoplasm into neighboring regions of the brain is highly reliant on cell migration. This process is triggered by highly regulated signaling pathways that involve the activation of Rho GTPases. Palladin, a newly discovered actin-associated phosphoprotein, has been linked to cell motility, adhesion and invasion in various cancer types through the modulation of Rho GTPases. As such, our research aimed to examine the role of Palladin in glioblastoma 2D cell migration as well as its role as a regulator of the activity of two extensively studied Rho GTPases, Cdc42 and Rac1. The findings of this study suggest that Palladin is indeed a positive modulator of the migration of glioblastoma cells. |
| eu_rights_str_mv | openAccess |
| format | masterThesis |
| id | LAURepo_9e77983fa9f665a2fa31148182bafa74 |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/15138 |
| publishDate | 2023 |
| publisher.none.fl_str_mv | Lebanese American University |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Palladin is a Selective Regulator of Rho GTPases During Cancer Cell MigrationEl Jaafari, NourGlioblastoma multiformeCancer cells -- MotilityCell migrationRho GTPasesLebanese American University -- DissertationsDissertations, AcademicGlioblastoma multiforme (GBM) is a highly aggressive and infiltrative brain tumor that carries a poor prognosis and mostly originates from normal astrocytic glial cells. The dissemination of this rapidly proliferating neoplasm into neighboring regions of the brain is highly reliant on cell migration. This process is triggered by highly regulated signaling pathways that involve the activation of Rho GTPases. Palladin, a newly discovered actin-associated phosphoprotein, has been linked to cell motility, adhesion and invasion in various cancer types through the modulation of Rho GTPases. As such, our research aimed to examine the role of Palladin in glioblastoma 2D cell migration as well as its role as a regulator of the activity of two extensively studied Rho GTPases, Cdc42 and Rac1. The findings of this study suggest that Palladin is indeed a positive modulator of the migration of glioblastoma cells.1 online resource (xv, 57 leaves):ill. (some col.)Includes bibliographical references (leaves 49-57).Lebanese American University2023-10-24T09:58:35Z2023-10-24T09:58:35Z20232023-04-28Thesisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesishttp://hdl.handle.net/10725/15138https://doi.org/10.26756/th.2023.623http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.phpeninfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/151382024-02-22T12:16:06Z |
| spellingShingle | Palladin is a Selective Regulator of Rho GTPases During Cancer Cell Migration El Jaafari, Nour Glioblastoma multiforme Cancer cells -- Motility Cell migration Rho GTPases Lebanese American University -- Dissertations Dissertations, Academic |
| status_str | publishedVersion |
| title | Palladin is a Selective Regulator of Rho GTPases During Cancer Cell Migration |
| title_full | Palladin is a Selective Regulator of Rho GTPases During Cancer Cell Migration |
| title_fullStr | Palladin is a Selective Regulator of Rho GTPases During Cancer Cell Migration |
| title_full_unstemmed | Palladin is a Selective Regulator of Rho GTPases During Cancer Cell Migration |
| title_short | Palladin is a Selective Regulator of Rho GTPases During Cancer Cell Migration |
| title_sort | Palladin is a Selective Regulator of Rho GTPases During Cancer Cell Migration |
| topic | Glioblastoma multiforme Cancer cells -- Motility Cell migration Rho GTPases Lebanese American University -- Dissertations Dissertations, Academic |
| url | http://hdl.handle.net/10725/15138 https://doi.org/10.26756/th.2023.623 http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php |