Portal vein embolization before major hepatectomy and its effects on regeneration, resectability and outcome
Background: This study evaluated the safety of portal vein embolization (PVE), its impact on future liver remnant (FLR) volume and regeneration, and subsequent effects on outcome after liver resection. Methods: Records of 112 patients were reviewed. Standardized FLR (sFLR) and degree of hypertrophy...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , |
| التنسيق: | article |
| منشور في: |
2007
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/2577 http://dx.doi.org/10.1002/bjs.5836 http://onlinelibrary.wiley.com/doi/10.1002/bjs.5836/full |
| الوسوم: |
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| _version_ | 1864513458648645632 |
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| author | Madoff, D.C. |
| author2 | Abdalla, Eddie Donadon, M. Loyer, E.M. Vauthey, J.-N. Ribero, D. |
| author2_role | author author author author author |
| author_facet | Madoff, D.C. Abdalla, Eddie Donadon, M. Loyer, E.M. Vauthey, J.-N. Ribero, D. |
| author_role | author |
| dc.creator.none.fl_str_mv | Madoff, D.C. Abdalla, Eddie Donadon, M. Loyer, E.M. Vauthey, J.-N. Ribero, D. |
| dc.date.none.fl_str_mv | 2007 2015-11-16T10:15:58Z 2015-11-16T10:15:58Z 2015-11-16 |
| dc.identifier.none.fl_str_mv | 0007-1323 http://hdl.handle.net/10725/2577 http://dx.doi.org/10.1002/bjs.5836 Ribero, D., Abdalla, E. K., Madoff, D. C., Donadon, M., Loyer, E. M., & Vauthey, J. N. (2007). Portal vein embolization before major hepatectomy and its effects on regeneration, resectability and outcome. British Journal of Surgery, 94(11), 1386-1394. http://onlinelibrary.wiley.com/doi/10.1002/bjs.5836/full |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | British Journal of Surgery |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Portal vein embolization before major hepatectomy and its effects on regeneration, resectability and outcome |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Background: This study evaluated the safety of portal vein embolization (PVE), its impact on future liver remnant (FLR) volume and regeneration, and subsequent effects on outcome after liver resection. Methods: Records of 112 patients were reviewed. Standardized FLR (sFLR) and degree of hypertrophy (DH; difference between the sFLR before and after PVE), complications and outcomes were analysed to determine cut-offs that predict postoperative hepatic dysfunction. Results: Ten (8·9 per cent) of 112 patients had PVE-related complications. Postoperative complications occurred in 34 (44 per cent) of 78 patients who underwent hepatic resection and the 90-day mortality rate was 3 per cent. A sFLR of 20 per cent or less after PVE or DH of not more than 5 per cent (versus sFLR greater than 20 per cent and DH above 5 per cent) had a sensitivity of 80 per cent and a specificity of 94 per cent in predicting hepatic dysfunction. Overall, major and liver-related complications, hepatic dysfunction or insufficiency, hospital stay and 90-day mortality rate were significantly greater in patients with a sFLR of 20 per cent or less or DH of not more than 5 per cent compared with patients with higher values. Conclusion: DH contributes prognostic information additional to that gained by volumetric evaluation in patients undergoing PVE. Copyright © 2007 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_9ea7fce41e9181c9f66f87fa46b93182 |
| identifier_str_mv | 0007-1323 Ribero, D., Abdalla, E. K., Madoff, D. C., Donadon, M., Loyer, E. M., & Vauthey, J. N. (2007). Portal vein embolization before major hepatectomy and its effects on regeneration, resectability and outcome. British Journal of Surgery, 94(11), 1386-1394. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/2577 |
| publishDate | 2007 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Portal vein embolization before major hepatectomy and its effects on regeneration, resectability and outcomeMadoff, D.C.Abdalla, EddieDonadon, M.Loyer, E.M.Vauthey, J.-N.Ribero, D.Background: This study evaluated the safety of portal vein embolization (PVE), its impact on future liver remnant (FLR) volume and regeneration, and subsequent effects on outcome after liver resection. Methods: Records of 112 patients were reviewed. Standardized FLR (sFLR) and degree of hypertrophy (DH; difference between the sFLR before and after PVE), complications and outcomes were analysed to determine cut-offs that predict postoperative hepatic dysfunction. Results: Ten (8·9 per cent) of 112 patients had PVE-related complications. Postoperative complications occurred in 34 (44 per cent) of 78 patients who underwent hepatic resection and the 90-day mortality rate was 3 per cent. A sFLR of 20 per cent or less after PVE or DH of not more than 5 per cent (versus sFLR greater than 20 per cent and DH above 5 per cent) had a sensitivity of 80 per cent and a specificity of 94 per cent in predicting hepatic dysfunction. Overall, major and liver-related complications, hepatic dysfunction or insufficiency, hospital stay and 90-day mortality rate were significantly greater in patients with a sFLR of 20 per cent or less or DH of not more than 5 per cent compared with patients with higher values. Conclusion: DH contributes prognostic information additional to that gained by volumetric evaluation in patients undergoing PVE. Copyright © 2007 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.PublishedN/A2015-11-16T10:15:58Z2015-11-16T10:15:58Z20072015-11-16Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0007-1323http://hdl.handle.net/10725/2577http://dx.doi.org/10.1002/bjs.5836Ribero, D., Abdalla, E. K., Madoff, D. C., Donadon, M., Loyer, E. M., & Vauthey, J. N. (2007). Portal vein embolization before major hepatectomy and its effects on regeneration, resectability and outcome. British Journal of Surgery, 94(11), 1386-1394.http://onlinelibrary.wiley.com/doi/10.1002/bjs.5836/fullenBritish Journal of Surgeryinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/25772019-02-26T10:47:09Z |
| spellingShingle | Portal vein embolization before major hepatectomy and its effects on regeneration, resectability and outcome Madoff, D.C. |
| status_str | publishedVersion |
| title | Portal vein embolization before major hepatectomy and its effects on regeneration, resectability and outcome |
| title_full | Portal vein embolization before major hepatectomy and its effects on regeneration, resectability and outcome |
| title_fullStr | Portal vein embolization before major hepatectomy and its effects on regeneration, resectability and outcome |
| title_full_unstemmed | Portal vein embolization before major hepatectomy and its effects on regeneration, resectability and outcome |
| title_short | Portal vein embolization before major hepatectomy and its effects on regeneration, resectability and outcome |
| title_sort | Portal vein embolization before major hepatectomy and its effects on regeneration, resectability and outcome |
| url | http://hdl.handle.net/10725/2577 http://dx.doi.org/10.1002/bjs.5836 http://onlinelibrary.wiley.com/doi/10.1002/bjs.5836/full |